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THURSDAY, MARCH 2ND
08.25 - 08.30 Welcome and Opening of the 3rd Scientific Meeting of the Heart Valve Society
Gilles Dreyfus, MD, President of the Heart Valve Society
08.30 - 09.45 Opening Plenary Session
Moderator: Gilles Dreyfus, MD
08.30 - 08.45 Valve Leaflet Thrombosis Post-TAVI: A Mirage or a Reality?
Vinod Thourani, MD
08.45 - 09.00 Is There a Risk in Avoiding Risk?
Hanneke Takkenberg, MD, PhD
09.00 - 09.15 TAVR vs. Surgery in 2017: When Less is More and When More is More!
Martin Leon, MD
09.15 - 09.30 Translating Heart Valve Tissue Engineering to the Clinic
Simon Hoerstrup, MD, PhD
09.30 - 09.45 Repair is Always Preferred To Replacement?
Jean Louis Vanoverschelde, MD
09.45 - 10.00 Presidential Address
Functional MR: Are We Wrong All the Way?
Gilles Dreyfus, MD
10.00 - 10.30 Coffee Break & Poster Viewing
10.30 - 12.00 Concurrent Session I: Endocarditis: An Ongoing Challenging Disease
Moderators: Raphael Rosenhek, MD
Gilbert Habib, MD
10.30 - 10.50 Prosthetic Valve Endocarditis and Tavi Endocarditis: The Achilles Heels of TAVR
Gilbert Habib, MD
10.50 - 11.10 Neurological Complications: Is it Contraindicated to do Surgery?
Michael Borger, MD
11.10 - 11.30 IE During Pregnancy
Marta Sitges, MD
11.30 - 11.50 Can the Guidelines Solve all the Problems?
Raphael Rosenhek, MD
11.50 - 12.00 Discussion
10.30 - 12.00 Concurrent Session II: MitraClip: Lights and Shadows
Moderators: Michele De Bonis, MD, FESC
Nicola Buzzatti, MD
10.30 - 10.42 MitraClip's Updates on Clinical Evidence
Edith Lubos, MD
10.42 - 10.48 Discussion
10.48 - 11.00 MitraClip's Current Limitations
Michele De Bonis, MD, FESC
11.00 - 11.06 Discussion
11.06 - 11.18 When to Do it, When to Avoid it: Clinical and Anatomic Selection for MitraClip
Martin Swaans, MD
11.18 - 11.24 Discussion
11.24 - 11.36 MitraClip's Role in Challenging and Unusual Scenarios (case-based)
Ralph Stephan von Bardeleben
11.36 - 11.42 Discussion
11.42 - 11.54 Should MitraClip and Surgery Compete?
Francesco Maisano, MD
11.54 - 12.00 Discussion
10.30 - 12.00 Concurrent Session III: How can Biomarkers Optimize the Timing of Heart Valve Surgery?
Moderators: Mostafa Mokhles, MD, PhD
Mare Annick Clavel, DVM, PhD
10.30 - 10.45 “Hot” Biomarkers in Aortic Disease
Marie Annick Clavel, DVM, PhD
10.45 - 11.00 "Hot" Biomarkers in Mitral Regurgitation
Thierry Le Tourneau, MD, PhD
11.00 - 11.15 What is the Best Way to Measure Frailty in Elderly HVD Patients?
Volkmar Falk, MD
11.15 - 11.30 The Role of Natriuretic Peptides in Patients with Severe Aortic Stenosis
Jutta Bergler-Klein, MD
11.30 - 11.45 Longitudinal and Mixed Modelling of Biomarkers to Optimize the Timing of Treatment
Mostafa Mokhles, MD, PhD
11.45 - 12.00 Discussion
10.30 - 12.00 Concurrent Session IV: Percutaneous Heart Valve Therapy Keynote & Abstracts
Moderator: Vinod Thourani, MD
10.30 - 10.40 Keynote
Vinod Thourani, MD

Presenter is allowed 5 minutes for presentation followed by 3 minutes of discussion and questions
10 Abstracts
A01 Stentless vs. Stented Aortic Valve-in-Valve Implantation: Insights from the Valve-in-Valve International Data Registry (VIVID)
Alison Duncan1, Neil Moat1, Matheus Simonato2, John Webb3, Vinayak Bapat4, Thierry Lefevre5, Guilherme Attizzani6, Jose Maria Hernandez7, Pedro Lemos8, Robert Welsh9, Alessandro Iadanza10, Stefano Salizzoni11, Marco Agrifoglio12, Patrizia Presbitero13, Giuseppe Bruschi14, Filip Casselman15, Dominique Himbert16, Raj Makkar17, Arash Salemi18, Farrel Hellig19, Sameer Gafoor20, Tarun Chakravarty17, Amit Segev21, Ariel Finkelstein22, Ran Kornowski23, Danny Dvir24.
1Royal Brompton Hospital, London, United Kingdom, 2Escola Paulista de Medicina - UNIFESP, Sao Paulo, Brazil, 3St. Paul's Hospital, Vancouver, BC, Canada, 4Guys and St. Thomas Hospital, London, United Kingdom, 5Institut Cardiovasculaire Paris Sud Massy, Paris, France, 6University Hospitals, Cleveland, OH, USA, 7Hospital Universitario Virgen de la Victoria, Malaga, Spain, 8Faculdade de Medicina da USP, Sao Paulo, Brazil, 9Mazankowski Alberta Heart Institute, Edmonton, AB, Canada, 10Azienda Ospedaliera Universitaria Senese, Siena, Italy, 11Città della Salute e della Scienza, Torino, Italy, 12Cardiologico Monzino, Milan, Italy, 13Humanitas, Milan, Italy, 14Niguarda Hospital, Milan, Italy, 15OLV Clinic, Aalst, Belgium, 16Hôpitaux de Paris, Paris, France, 17Cedars Sinai, Los Angeles, CA, USA, 18Cornell University, New York, NY, USA, 19Sunninghill Hospital, Johannesburg, South Africa, 20Swedish Medical Center, Seattle, WA, USA, 21Sheba Medical Center, Ramat Gan, Israel, 22Tel-Aviv Medical Center, Tel-Aviv, Israel, 23Rabin Medical Center, Petah Tikva, Israel, 24University of Washington Medical Center, Seattle, WA, USA.
A02 Male vs. female aortic valve-in-valve implantation: Insights from the Valve-In-Valve International Data Registry (VIVID)
Tara Jones1, Matheus Simonato2, Moses Mathur1, Mark Reisman1, John Webb3, Danny Dvir1.
1University of Washington Medical Center, Seattle, WA, USA, 2Escola Paulista de Medicina - UNIFESP, Sao Paulo, Brazil, 3St. Paul's Hospital, Vancouver, BC, Canada.
A03 Design Changes Can Explain The Trends Of Reported Adverse Events Associated With Balloon Expandable And Self-expandable Transcatheter Aortic Valves
Bruce Murphy, Travis Davis, Sam Coffey, Corinna Welker, Deirdre Moroney, Jack Halpin.
Trinity College Dublin, Dublin, Ireland.
A04 Comparison Of Hemodynamics And Left Ventricular Mass Regression Between TAVI And SAVR With Simple Interrupted Suturing Technique
Kazuhiro Naito, Kin Hajime, Kazutoshi Tachibana, Kosaku Nishigawa, Shuichiro Takanashi.
Sakakibara Heart Institute, Tokyo, Japan.
A05 Electrocardiographic Changes Associated with Transapical Transcatheter Aortic Valve Implantation
berhane worku1, James Horowitz2, polydoros Kampaktsis2, Iosif Gulkarov1, Arash Salemi2.
1weill cornell medical center, Brooklyn, NY, USA, 2weill cornell medical center, New York, NY, USA.
A06 Transcatheter versus Surgical Aortic Valve Replacement in Patients with Prior Mitral Valve Surgery
Jessica Forcillo, MD, John Kelly, Jose N. Binongo, PhD, Vasilis Babaliaros, MD, Robert A. Guyton, MD, Chandan Devireddy, MD, Bradley G. Leshnower, MD, James P. Stewart, MD, Vinod Thourani, MD.
Emory University, Atlanta, GA, USA.
A07 Impact Of TAVI Programme On Surgical AVR Workload In A Single Institution
Tom Combellack, Yasir Ahmed, Alex Chase, Dave Smith, Aprim Youhana, Pankaj Kumar.
Morriston Hospital, Swansea, United Kingdom.
A08 Small Size Self Expandable - Versus Balloon Expandable Transcatheter Aortic Valve Prosthesis. Comparison Of Early Postoperative Hemodynamic Function And Outcomes.
Mirko Doss, Thomas Walther.
Kerckhoff Heart Center, Bad Nauheim, Germany.
A09 Making the Call of Aortic Valve Choice in the Intermediate Risk Population in the Era of Transcatheter Therapy
elizabeth walsh, RN, Zachary Fox, Rachel Callahan, Mary Siki, Madeleine Walsh, Marisa Konig, RN, Laura Schuck, Laura Schuck, Matthew Williams, MD, Krimi Patel, Robert Li, MD, Jay Giri, MD, Saif Anwaruddin, MD, Nimesh Desai, MD, Wilson Szeto, MD, Howard Herrmann, MD, Joseph Bavaria, MD.
The University of Pennsylvania Hospital, Philadelphia, PA, USA.
10.30 - 12.00 Concurrent Session V: Tissue Engineering Heart Valves - Keynote & Abstracts
Moderator: Jane Grande-Allen, PhD
10.30 - 10.40 Keynote
Jane Grande-Allen, PhD

Presenter is allowed 5 minutes for presentation followed by 3 minutes of discussion and questions
10 Abstracts
A10 The Subclavian Artery, An Alternative Route For TAVI, A Propensity-score Matched Analysis
Nicolas d'Ostrevy, Geraud Souteyrand, Bruno Pereira, Nicolas Combaret, Andrea Innorta, Kasra Azarnoush, Lionel Camilleri.
CHU G Montpied, Clermont-ferrand, France.
A11 Tricuspid Valve ECM Tube Graft exhibits Growth Potential in a Porcine Model
Diana M. Ropcke, Christine Ilkjaer, Marcell J. Tjornild, Soren N. Skov, Steffen Ringgaard, Vibeke E. Hjortdal, Sten L. Nielsen.
Aarhus University Hospital, Aarhus N, Denmark.
A12 Macrophage Polarization State Influences Synthetic Heart Valve Degradation: Insights In The Fragile Balance Between Tissue Formation And Biomaterial Degradation
Tamar Wissing1, Marieke Brugmans2, Anthal Smits3, Carlijn Bouten3.
1Technical University Eindhoven, Eindhoven, Netherlands, 2Xeltis B.V., & Technical University Eindhoven, Eindhoven, Netherlands, 3Institute for Complex Molecular Systems & Technical University Eindhoven, Eindhoven, Netherlands.
A13 In Vitro Biomechanical Evaluation Of Pre-implanted And Post-implanted Decellularised Porcine Pulmonary Valve Conduits
A Desai1, T Vafaee1, H E. Berry2, J Roderjan3, Costa da4, E Ingham1, J Fisher1.
1University of Leeds, Leeds, United Kingdom, 2University of Leeds & Tissue Regenix Ltd. The Biocentre, Innovation Way, York, United Kingdom, 3Pontificia Universidade Catolica do Parana (PUCPR), Curitiba, Parana, Brazil, 4Pontificia Universidade Catolica do Parana (PUCPR) & Santa Casa Misericordia Curitiba, Curitiba, Parana, Brazil.
A14 WITHDRAWN
A15 Long-term Follow-up Results After Allogenic Implantation Of In-body Tissue-engineered Heart Valves (bivalves) As A Pulmonary Valve In A Goat Model
Yasuhide Nakayama, Yoshiaki Takewa, Takeshi Terazawa, Eisuke Tatsumi.
National Cerebral and Cardiovascular Center, Osaka, Japan.
A16 Longterm Evaluation of a Novel Autologous Tissue Heart Valve
Yoshiaki Takewa, Yasuhide Nakayama, Hirohito Sumikura, Kei Iizuka, Daichi Akiyama, Eisuke Tatsumi.
National Cerebral and Cardiovascular Center, Osaka, Japan.
A17 The Potential of Protein Functionalized Electrospun Scaffolds for Heart Valve Engineering
Svenja Hinderer1, Andrea Kulessa2, Katja Schenke-Layland1.
1Fraunhofer IGB, Stuttgart, Germany, 2University of Tübingen, Tübingen, Germany.
A18 Temporal Evaluation of Decellularised Porcine Pulmonary Root Performance and Regeneration in a Juvenile Sheep Model
Helen E. Berry1, Tayyebeh Vafaee2, Fiona Walker2, Amisha Desai3, Louise M. Jennings3, João G. Roderjan4, Claudinei Collatusso5, Francisco D. da Costa6, John Fisher3, Eileen Ingham2.
1Institute of Medical and Biological Engineering, School of Biomedical Sciences, University of Leeds; and Tissue Regenix Group Plc, Leeds, United Kingdom, 2Institute of Medical and Biological Engineering, School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom, 3Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, United Kingdom, 4Pontificia Universidade Catolica do Parana (PUCPR), Curitiba, Brazil, 5Santa Casa Misericordia Curitiba, Curitiba, Brazil, 6Pontificia Universidade Catolica do Parana (PUCPR) and Santa Casa Misericordia Curitiba, Curitiba, Brazil.
A19 iPSC-Derived Induced Mesenchymal Stem Cells as a Potential Cell Source for Tissue Engineered Heart Valves
Aline L. Yonezawa Nachlas1, Monalisa Singh2, Siyi Li1, David Safranski3, Kenneth Dupont3, Chunhui Xu2, Michael E. Davis1.
1Georgia Institute of Technology & Emory University, Atlanta, GA, USA, 2Children's Healthcare of Atlanta & Emory University, Atlanta, GA, USA, 3Medshape Inc., Atlanta, GA, USA.
10.30 - 12.00 Concurrent Session VI: Rheumatics Disease: Advances and Innovations
Moderators: Taweesak Chotivatanapong, MD
Jose Pomar, MD
10.30 - 10.45 Rheumatic Valvuler Disease: Current Burden and Strategy of Management.
Jose Pomar, MD
10.45 - 11.00 Long Term Results of Rheumatic MV Repair
Gebrine El Khoury, MD
11.00 - 11.15 What to Do with Tricuspid Valve Problem: Current Understanding and Management
Gilles Dreyfus, MD
11.15 - 11.30 Innovative Approaches for Repairing Calcified Stenotic MV
Taweesak Chotivatanapong, MD
11.30 - 11.45 Best Choice of Prosthetic Valve Replacement in Current Era
Song Wan, MD
11.45 - 12.00 Transcatheter valve for rheumatic disease: Fad or real?
Jose Pomar, MD
12.00 - 13.30 Industry Lunch Symposium 1
Latest Innovation in Cardiac Surgery
Supported by LivaNova
12.00 - 13.30 Industry Lunch Symposium 2
Indications and Treatment Options for Concomitant to Mitral Patients
Supported by Medtronic
12.00 - 13.30 AVIATOR Network Meeting 1
13.30 - 15.15 Concurrent Session I: Hot Topics in TAVR
Moderators: Vinod Thourani, MD
Martin Leon, MD
13.30 - 13.42 Why TAVR Will be the “Standard-of-Care” for the Management of Aortic Stenosis Within 5 Years
Martin Leon, MD
13.42 - 13.54 Deciding on SAVR or TAVR Based on Anatomic and Clinical Characteristics
Neil Moat, MD
13.54 - 14.06 New Concerns Associated with TAVR: From Leaflet Immobility to Structural Valve Degeneration to Durability Issues
Martin Leon, MD
14.06 - 14.15 Panel Discussion
14.15 - 14.27 Alternative Access Strategies to Transfemoral (and Transapical) TAVR: From Subclavian to Transcarotid to Transcaval to Suprasternal Approaches
Vinod H. Thourani, MD
14.27 - 14.39 Valve-in-Valve TAVR: Technical Considerations and Clinical Outcomes
Murat Tuzcu, MD
14.39 - 14.51 Transcatheter Approaches to Aortic Insufficiency
Manuel Wilbring, MD
14.51 - 15.01 Stroke after TAVR: Changing Incidence, Predictors, and the Use of Embolic Protection
Susheel Kodali, MD
15.01 - 15.15 Panel Discussion
13.30 - 15.00 Concurrent Session II: Should We Implant Biological or Mechanical Valves in Young Patients?
Moderators: Ismail El-Hamamsy, MD, PhD
Diana Aicher, MD
13.30 - 13.45 The Case for Biological Valves in Young Patients
Ismail El-Hamamsy, MD, PhD
13.45 - 14.00 The Case for Mechanical Valves in Young Patients
Walter P Dembitsky, MD
14.00 - 14.15 Quality of Life After Heart Valve Replacement in Young Patients
Diana Aicher, MD
14.15 - 14.30 What is the Role of the Ross Procedure in Young Adults?
Mostafa Mokhles, MD, PhD
14.30 - 14.45 What Do You Tell Young Adult Patients Who are Facing Prosthetic Valve Selection? (Focus on Women, Active Life and ViV)
Jean Louis Vanoverschelde, MD
14.45 - 15.00 Discussion
13.30 - 15.00 Concurrent Session III: Secondary Tricuspid Regurgitation after Pervious Mitral Surgery
Moderators: Marta Sitges, MD
Michael Borger, MD
13.30 - 13.45 Why did Tricuspid Regurgitation Develop in this Patient Years after Mitral Valve Surgery?
Marta Sitges, MD
13.45 - 14.00 Evaluation of Tricuspid Regurgitation with Imaging: Always Reliable?
Marco Merlo, MD
14.00 - 14.15 Should All Patients Undergoing Mitral Valve Surgery be Treated with Tricuspid Annuloplasty or Should We Make a Selective Approach?
Michael Borger, MD
14.15 - 14.30 Advances in Surgical Repair of the Tricuspid Valve.
Jerry Braun, MD
14.30 - 14.45 Will the Treatment of Secondary Tricuspid Regurgitation be Percutaneous?
Francesco Maisano, MD
14.45 - 15.00 Discussion
13.30 - 15.00 Concurrent Session IV: Minimally Invasive Valve and Robotic - Keynote & Abstracts
Moderator: Rakesh Suri, MD
13.30 - 13.40 Keynote
Rakesh Suri, MD

Presenter is allowed 5 minutes for presentation followed by 3 minutes of discussion and questions
10 Abstracts
A21 Comparison of Minimally Invasive Approach with Conventional Sternotomy in Reoperative Mitral Valve Surgery After Previous Sternotomy
Ho Jin Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee.
Asan Medical Center, Seoul, Korea, Republic of.
A22 Minimally Invasive Aortic Valve Replacement: Ministernotomy or Minithoracotomy?
Mauro Del Giglio, M.D., Elisa Mikus, Simone Calvi.
Maria Cecilia Hospital, GVM for Care & Research, Cotignola (Ra), Italy.
A23 Minimally Invasive Tricuspid Valve Surgery In Patients At High Risk
Davide Ricci, Cristina Barbero, Augusto Pellegrini, Suad ElQarra, Giovanni Marchetto, Massimo Boffini, Mauro Rinaldi.
AOU Città della Salute e della Scienza di Torino - University of Turin, Turin, Italy.
A23 A New Approach for Minimally Invasive Mitral Valve Surgery: The Periareolar Access
Robinson Poffo, Paola K. Montanhesi, Alisson P. Toschi, Renato B. Pope, Claudio A. Mokross.
Hospital Isrealita Albert Einstein, Sao Paulo, Brazil.
A24 Off Pump Mitral Valve Repair With Neochord From Pioneering To Clinical Practise. Early Experience From Two Associate Centers: What We Are Learning
ALBERTO ALBERTINI1, Luigi Martinelli2, Luca Caprili1, Leopoldo Bardano2.
1SALUS HOSPITAL GVM Care & Research, REGGIO EMILIA, Italy, 2ICLAS GVM Care & Research, Rapallo, Italy.
A26 A Simplified, Reproducible Cost Effective Approach To Robotic Mitral Valve Repair
Casey Hertzenberg, Maureen McKiernan, Emmanuel Daon.
University of Kansas Hospital, Kansas City, KS, USA.
A27 3D compared to 2D Video Assistance Improves Early Outcomes in Minimally Invasive Mitral Valve Repair Surgery
Eilon Ram, Ami Shinfeld, Eyal Nahum, Ronny Ben-Avi, Alexander Kogan, Sergey Preisman, Shany Levin, Sagit Ben Zekry, Ehud Raanani.
Sheba Medical Center, Israel, Ramat Gan, Israel.
A28 Aortic Valve Replacement via Partial Sternotomy as the Standard Incision: Short-term Outcomes and Comparison of Conventional and Sutureless Prostheses
Petr Budera, Miroslav Kolesar, David Talavera, Zbynek Straka.
University Hospital Kralovske Vinohrady, Prague 10, Czech Republic.
13.30 - 15.00 Concurrent Session V: Basic Research – Valve Science and Diseases - Keynote & Abstracts
Moderator: Jordan Miller, PhD
13.30 - 13.40 Keynote
Jordan Miller, PhD

Presenter is allowed 5 minutes for presentation followed by 3 minutes of discussion and questions
A31 Protein-Altering and Regulatory Genetic Variants Near GATA4 Implicated in Bicuspid Aortic Valve
Bo Yang1, Wei Zhou1, Jiao Jiao1, Jonas Nielsen1, Michael Mathis1, Mahyar Heydarpour2, Guillaume Lettre3, Lasse Folkersen4, Siddharth Prakash5, Claudia Schurmann6, Maoxuan Lin1, Mohammad Othman1, Jacob Kitzman1, Alan Boyle1, Santhi Ganesh1, Gonçalo Abecasis1, Kim Eagle1, Ruth J.F. Loos6, Per Eriksson4, Jean-Claude Tardif3, Chad M. Brummett1, Dianna Milewicz5, Simon Body2, Cristen Willer1.
1University of Michigan, Ann Arbor, MI, USA, 2Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, 3Université de Montréal, Montreal, QC, Canada, 4Karolinksa University Hospital Solna, Karolinska Institutet, Stockholm, Sweden, 5University of Texas Health Science Center at Houston, Houston, TX, USA, 6The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
A32 Treatment with XAV-939 prevents in vitro Calcification and induces SOX9 Expression in Human Aortic Valvular Interstitial Cells
Claudia Dittfeld1, Gabriel Reimann1, Alice Mieting1, Anett Jannasch1, Katrin Plötze1, Gerald Steiner2, Klaus Matschke1, Sems Malte Tugtekin1.
1Technische Universität Dresden, Faculty of Medicine Carl Gustav Carus, Department of Cardiac Surgery, Herzzentrum Dresden, Dresden, Germany, 2Technische Universität Dresden, Faculty of Medicine Carl Gustav Carus, Clinical Sensoring and Monitoring, Dresden, Germany.
A33 Mitral Regurgitation from a Leaflet Perspective: Ex Vivo Modeling Reveals Early Pathogenesis
Katsuhide Maeda, Xiaoyuan Ma, Frank Hanley, R. Kirk Riemer.
Stanford University, Stanford, CA, USA.
A34 Regulation of Aortic Valve EndMT and Calcific Susceptibility via Canonical NFkB Signaling
Terence Gee1, Emily Farrar1, Kevin Hsu1, Bin Zhou2, Jonathan Butcher1.
1Cornell University, Ithaca, NY, USA, 2Einstein College of Medicine, New York, NY, USA.
A35 Transcriptional Differences in Left Ventricular Extracellular Matrix Remodeling in Primary and Secondary Mitral Regurgitation
Daniella Espiritu, Daisuke Onohara, Muralidhar Padala.
Emory University, Atlanta, GA, USA.
A36 Wall Shear Stress from the Fused Bicuspid Aortic Valve Leaflet Induces Acute Remodeling and Cytokine Responses in Normal Porcine Aortic Valve Tissue
Samantha K. Atkins1, Janet Liu2, Johana Barrientos2, Philippe Sucosky2.
1University of Notre Dame, South Bend, IN, USA, 2Wright State University, Dayton, OH, USA.
A37 Towards A Warfarin-free Mechanical Heart Valve Substitute
Walter Dembitsky, Sr.1, Penelope Leyland, Mrs2, Stefano Mischler3, Angelo Casagrande, PhD3, Michele Gaffuri, PhD2, Bernhard Vennemann, PhD4, Dominik Obrist, PhD5, Jean Geringer, PhD6, Thierry Carrel, MD7, Gilles Dreyfus, MD8, Didier Lapeyre, MD9.
1Sharp Hospital,, San Diego, CA, USA, 2EPFL, Lausanne,, Switzerland, 3EPFL, Lausanne, Switzerland, 4ETHZ, Zurich, Switzerland, 5ARTORG Center, Bern, Switzerland, 6Ecole des Mines, Saint-Etienne, France, 7Inselspital, University of Bern, Bern, Switzerland, 8Cardiothoracic Centre of Monaco, Monaco, Monaco, 9Triflo Medical Switzerland, Neuchatel, Switzerland.
A38 Novel Protective Genes Associated with Aortic Dilation in Bicuspid Aortic Valve Disease
Mahyar Heydarpour1, Martin Sigurdsson1, Karam Habchi1, Vanessa Montiero Vieira1, Tsuyoshi Kaneko1, Prem Shekar1, Thoralf Sundt, III2, Jochen Muehlschlegel1, B AV Consortium1, Simon C. Body1.
1Brigham and Women's Hospital, Boston, MA, USA, 2Massachusetts General Hospital, Boston, MA, USA.
13.30 - 15.00 Concurrent Session VI: 101: (Lies, Damned Lies and) Statistics in Heart Valve Disease
Moderators: Johanna Takkenberg, MD, PhD
Jeffery Borer, MD
13.30 - 13.45 What is the True Prevalence of the Heart Valve Disease and Do We Actually Have an Epidemic?
Raphael Rosenhek, MD
13.45 - 14.00 Can You Trust Randomized Clinical Trials in Heart Valve Interventions?
Hanneke Takkenberg, MD, PhD
14.00 - 14.15 How to Assess the Validity of the Design, Statics, and Reported Outcomes of Heart Valve Disease Studies
Tome Treasure, MD
14.15 - 14.30 How to Construct Objective Performance Criteria as Acceptable Historical Controls for Regulatory Approval of New Prosthetic Heart Valves
Jeffery Borer, MD
14.30 - 14.45 All you need to know about the heart valve Health Technology Assessment
Simone Huygens, PhD
15.00 - 15.30 Coffee Break & Poster Viewing
15.30 - 17.00 Afternoon Plenary Session: Rapid Fire and Pro/Con
Moderator: Martin Leon, MD
15.30 - 16.20 Rapid Fire Cases
Presenter is allowed 4 minutes for presentation followed by 3 minutes of discussion and questions
16.20 - 16.40 Debate 1: Echo vs MRI for Paravalvular Leaks after TAVR
Introduction: Murat Tuzcu, MD - 8 minutes
Echo: Hector Michelena, MD - 4 minutes
MRI: Carlos Ruiz, MD - 4 minutes
Discussion - 4 minutes
16.40 - 17.00 Debate 2: MitraClip vs Traditional Surgery
MitraClip: Francesco Maisano, MD - 5 minutes
Traditional Surgery: Volkmar Falk, MD - 5 minutes
Discussion - 10 minutes
17.00 - 17.15 Annual Business Meeting
17.15 - 19.00 Welcome Reception & Moderated Posters
Poster Head Moderator: Marta Sitges, MD

Poster Topic Judges:
Basic Research - Valve Science and Diseases - Jorge Solis & Harry Dietz
Experimental and Computational Valve Tissue Studies - Sandra Loerakker & Jane Grande-Allen
Heart Valve Imaging -
Heart Valve Outcomes - Hector Michelena & Marie Annick Clavel
Heart Valve Repair - Jose Pomar & Diana Aicher
Minimally Invasive Valve Surgery - Rakesh Suri & Volkmar Falk,
Percutaneous Heart Valve Therapy - Michele De Bonis
Tissue Engineered Heart Valves - Ulrich Stock, Max Emmert
FRIDAY, MARCH 3RD
07.00 - 08.30 Robotic Network Meeting
07.00 - 08.30 Tissue Engineering Network Meeting
07.00 - 08.30 Session I: Valve in Valve and Bioprosthesis Degeneration
Moderator: Danny Dvir, MD
07.00 – 07.05 Introduction
Danny Dvir, MD
07.05 – 07:20 Overview of Valve-in-Valve outcomes
Murat Tuzcu, MD
07.20 – 07.35 Valve-in-Valve in stentless surgical valves from the VIVID registry
Allison Duncan, MD
07.35 – 07.45 Implications of Valve-in-Valve to the original surgical procedure.
Jörg Kempfert, MD
07.45 – 08.00 Experimental bench testing to predict THV durability
Wei Sun, PhD
8:00 – 08.10 In vitro and in silico assessment of valve durability
Ulrich Steinseifer, MD
08.10 – 08.20 SAVR/TAVR degeneration: durability vs. treatability
Danny Dvir, MD
08.20 – 08.30 Questions and Answers
08.30 - 10.00 Concurrent Session I: Challenging Situations on AVR/TAVR
Moderator: Volkmar Falk, MD
08.30 - 08.45 Right-lateral Access for AVR: Tricks and Pitfalls
Alfred Kocher, MD
08.45 - 09.00 Hostile Landing Zones in TAVI Procedures
Axel Unbehaun, MD
09.00 - 09.15 Early Valve Thrombosis in sAVR/TAVI: Fiction or Reality
Gregory Fontana, MD
09.15 - 09.30 Durability of Transcatheter Aortic Valves: A Matter of Concern?
Danny Dvir, MD
09.30 - 09.45 Limitations of the VINV Concept: Implications for the Primary Procedure
Jörg Kempfert, MD
09.45 - 10.00 Discussion
08.30 - 10.00 Concurrent Session II: Valve Cell Biology and Pathology
Moderators: Michael Sacks, PhD
Jonathan Butcher, PhD
08.30 - 08.40 The Living Valve: The importance of cells
Ismail El-Hamamsy, MD, PhD
08.40 - 08.50 Valve Endothelial-Interstitial Cell Communication
Jonathan Butcher, PhD
08.50 - 09.00 Mechanobiology of Valve Function
Michael Sacks, PhD
09.00 - 09.10 Mechanotransduction in Valve Cells
Adrian Chester, PhD
09.10 - 09.20 Relevance of Hypoxia to Valve Function
Jane Grande-Allen, PhD
09.20 - 09.30 Drug Induced Valve Disease
Kartik Balachandran, PhD
09.30 - 10.00 Discussion
08.30 - 10.00 Concurrent Session III: EuroValve Collaborative Session - Low Gradient Aortic Stenosis
Moderators: Khalil Fattouch, MD
Gilbert Habib, MD
08.30 - 08.45 Classical and Paradoxical Low-Flow, Low-Gradient Aortic Stenosis
Madalina Garbi, MD
08.45 - 09.00 Normal-flow, Low-gradient Severe? Aortic Stenosis
Marie-Annick Clavel, MD
09.00 - 09.15 Aortic Stenosis with Concomitant Mitral Regurgitation
Raphael Rosenhek, MD
09.15 - 09.30 Moderate Aortic Stenosis with Depressed LVEF and HF symptoms
Ori Ben-Yehuda, MD
09.30 - 10.00 Discussion
08.30 - 10.00 Concurrent Session IV: Heart Valve Imaging Keynote & Abstracts
Moderator: Alain Berrebi, MD
08.30 - 08.40 Keynote
Alain Berrebi, MD

Presenter is allowed 5 minutes for presentation followed by 3 minutes of discussion and questions
10 Abstracts
A41 Relationship Between Coronary Artery Anomalies And Bicuspid Aortic Valve Disease
Shiho Naito, Johannes Petersen, Niklas Neumann, Tatiana Sequeira Gross, Yskert von Kodolitsch, Hermann Reichenspurner, Evaldas Girdauskas.
University Heart Center Hamburg, Hamburg, Germany.
A42 Does The Preoperative Transthoracic Or Transesophageal Echocardiogram Better Predict Mortality After Non-Mitral Valve Cardiac Surgery?
Shyamal Asher, Huan Wang, Gregory Malzberg, Prem Shekar, Tsuyoshi Kaneko, Stan Shernan, Jochen Muehlschlegel, Simon C. Body.
Brigham and Women's Hospital, Boston, MA, USA.
A43 3D Printed Modeling Of Mitral Valve Apparatus From Multi-modality Imaging
Marija Vukicevic, Eleonora Avenatti, Kinan Carlos El-Tallawi, Su Min Chang, Stephen H. Little.
The Methodist DeBakey Heart & Vascular Center, Houston, TX, USA.
A44 Atrial Fibrillation Is An Independent Predictor Of Outcome In Patients With Left Ventricular Dysfunction.
Giovanni Benfari, MD, Clemance Antoine, MD, Wayne L. Miller, MD, PhD, Hector I. Michelena, MD, Vuyisile T. Nkomo, MD, MPH, Maurice Enriquez-Sarano, MD.
Mayo Clinic, Rochester, MN, USA.
A45 Aortic Valve Calcification in Patients with Aortic Stenosis and Discordant Echocardiographic Measures
Tania A. Pawade, MD1, Marie-Annick Clavel, DVM, PhD2, Christophe Tribouilloy, MD, PhD3, Julien Dreyfus, MD, PhD4, Lionel Tastet, Msc5, Cedric Renard, MD6, Mesut Gun, MSc7, Laurent Macron, MD4, Jacob W. Sechrist, MD8, Joan Lacomis, MD8, Virginia Nguyen, MD9, Tiffany Mathieu, MD9, Laura G. Gay, MD10, Hug C. Calabria, MD, PhD10, Ioannis Ntalas, MD11, William S.A Jenkins, MD1, Anoop Shah, MD, PhD1, Timothy R.G Cartlidge, MD1, David E. Newby, Md, PhD1, Bernard Prendergast, DM, PhD11, Ronak Rajani, MD11, Arturo Evangelista, MD, PhD10, Joao L. Cavalcante, MD12, Philippe Pibarot, DVM, PhD13, David Messika-Zeitoun, MD, PhD14, Marc R. Dweck, MD, PhD1.
1University of Edinburgh, Edinbrugh, United Kingdom, 2Institut Universitaire de Cardiology et de Pneumologie de Québec (Quebec Heart and Lung Institute), Laval University, Quebed, QC, Canada, 3Department of Cardiology. Centre Hospitalier Universitaire d'Amiens, Picardie, Amiens, France, 4Centre Cardiologique du Nord,, Saint-Denis, France, 5. Institut Universitaire de Cardiology et de Pneumologie de Québec (Quebec Heart and Lung Institute), Laval University,, Quebec City, QC, Canada, 6Department of Cardiology, University Hospital Amiens, Amiens, France, 7Department of Radiology, University Hospital Amiens, Amiens, France, 8Department of Radiology, Division of Cardiothoracic Imaging, University of Pittsburgh/UPMC, Pittsburgh, PA, USA, 9Bichat Hospital, Paris, France, 10Department of Cardiology. Hospital Universitari Vall d'Hebron, Barcelona, Spain, 11Department of Cardiology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, 12Department of Medicine, Division of Cardiology,, University of Pittsburgh/UPMC, PA, USA, 13Institut Universitaire de Cardiology et de Pneumologie de Québec (Quebec Heart and Lung Institute), Laval University, Quebec City, QC, Canada, 14Department of Cardiology, Guy's and St Thomas' NHS Foundation Trust,, London, United Kingdom.
A46 Incremental Value of Transesophageal Echocardiography Integrated with Transthoracic Echocardiography in the Assessment of Aortic Stenosis Severity
Shmuel Schwartzenberg, Mordehay Vaturi, Daniel Monakier, Alexander Sagie, Ran Kornowski, Yaron Shapira.
Rabin Medical Center, Petah Tikva, Israel.
A47 In Vivo Identifying the Relationship of the Circumflex Artery to the Mitral Valve Annulus with the Use of a Preoperative Multi-slice Electrocardiogram Gated Coronary Computed Tomography Angiography
Vincenzo D. Caruso, Antonio Bivona, Mohamed Osman, Jessica Dada, Swamy Gedela, Ben Middleton, Walter Serino, Inderpaul Birdi.
Basildon and Thurrock University Hospital, Basildon, United Kingdom.
A48 Abnormal Systolic Strain Overestimates Myocardial Non-Viability In Patients With Ischemic Mitral Regurgitation
Ashley E. Morgan1, Yue Zhang2, Mehrzad Tartibi2, Samantha Goldburg3, Jiwon J. Kim3, Thanh D. Nguyen3, Liang Ge2, Jonathan W. Weinsaft3, Mark B. Ratcliffe4.
1UCSF East Bay, Oakland, CA, USA, 2Northern California Institute for Research and Education, San Francisco, CA, USA, 3Weill-Cornell Medical College, New York, NY, USA, 4San Francisco VA Medical Center, San Francisco, CA, USA.
A49 Intraoperative 3D Transoesophageal Valvular Evaluation
Tanja N. Anguseva, Sr., Zan Mitrev.
Special Hospital fro surgery Fillip II, Skopje, Macedonia, The Former Yugoslav Republic of.
08.30 - 10.00 Concurrent Session V: Heart Valve Outcomes Keynote & Abstracts
Moderator: Danny Dvir, MD
08.30 - 08.40 Keynote
Danny Dvir, MD

Presenter is allowed 5 minutes for presentation followed by 3 minutes of discussion and questions
10 Abstracts
A51 Left Atrium Volume Index Measurement In Routine Practice: Does It Independently Impact Survival Of Degenerative Mitral Valve Disease?
Clemence Antoine1, Giovanni Benfari1, Sorin V. Pislaru1, David Messika-Zeitoun2, Thierry Le Tourneau3, Joseph F. Maalouf1, Maurice Enriquez-Sarano1.
1Mayo Clinic, rochester, MN, USA, 2Bichat Claude Bernard Hospital-Paris VII University, Paris, France, 3The Division of Cardiovascular Diseases Universite de Nantes, Nantes, France.
A52 Evaluation Of MicroRNAs As Potential Biomarkers In BAV-associated Aortopathy: Preliminary Results
Evaldas Girdauskas, Johannes Petersen, Niklas Neumann, Tatiana Groß, Shiho Naito, Hermann Reichenspurner, Stefan Blanbenberg, Tanja Zeller.
University Heart Center Hamburg, Hamburg, Germany.
A52 Pericardial versus Porcine Valves for Surgical Aortic Valve Replacement
Joon Bum Kim, Hee Jung Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee.
Asan Medical Center, Seoul, Korea, Republic of.
A54 Benefits Of Oral Sildenafil Administration To Patients With Mitral Stenosis And Severe Pulmonary Hypertension Undergoing Mitral Valve Replacement
Sherif A. Mansour, Ashraf El Midany, Ahmed M. Habib.
Ain Shams University, Cairo, Egypt.
A55 The Prevalence and Prognostic Significance of Functional Mitral Regurgitation and Tricuspid Regurgitation Occurring Despite Preserved Left Ventricular Ejection Fraction in Patients with Atrial Fibrillation
Yukio Abe1, Kanako Akamatsu1, Kazato Ito1, Yoshiki Matsumura1, Takahiko Naruko1, Yosuke Takahashi2, Toshihiko Shibata2, Minoru Yoshiyama2.
1Osaka City General Hospital, Osaka, Japan, 2Osaka City University Medical School, Osaka, Japan.
A56 Thrombosis of Surgical Bioprosthetic Heart Valves - Insights from Reports to International Medical Device Vigilance Systems
Fritz Mellert1, Juliane Klein2, Toctam Bostani1, Georg D. Duerr1, Jan M. Sinning3, Dirk Wetzel†4, Armin Welz1, Christopher Gestrich1.
1Department of Cardiac Surgery, University of Bonn Heart Center, Bonn, Germany, 2Department of Anaesthesiology, University of Bonn, Bonn, Germany, 3Department of Medicine II, Cardiology, University of Bonn Heart Center, Bonn, Germany, 4Federal Institute for Drugs and Medical Devices, Bonn, Germany.
A57 Impact of Preoperative Renal Dysfunction on Mortality and Postoperative Outcomes in Mitral Valve Surgery
Xiaoying Lou, Jessica Forcillo, Michael Halkos, Jose Condado-Contreras, Jose Binongo, Yi Lasanajak, Douglas Murphy, Robert Guyton, Jeffrey Miller, Edward Chen, Omar Lattouf, Bradley Leshnower, Brent Keeling, Vinod Thourani.
Emory University, Atlanta, GA, USA.
A58 WITHDRAWN
A59 Prevalence, In-hospital Outcomes, and Prognostic Determinants of Triple Valve Surgery in the United States: The Role of Valve Repair in the Current Era.
Christopher Lau, Mario Gaudino, Luke Kim, Lucas Ohmes, Monica Munjal, Dmitry Feldman, Leonard Girardi.
Weill Cornell Medicine, New York, NY, USA.
08.30 - 10.00 Concurrent Session VI: Aortic Valve Repair: Time for Generalization
Moderators: Emanuel Lansac, MD
Jean Louis Vanoverschelde, MD
08.30 - 08.45 Repair or Replace: Which one is the alternative?
Hanneke Takkenberg, MD, PhD
08.45 - 09.00 Key parameters for reproducible cups repair?
Hans-Joachim Schäfers, MD
09.00 - 09.15 Bicuspid Valve Repair: One fits all?
Gebrine El Khoury, MD
09.15 - 09.30 Do We Operate to Late on Asymptomatic Patients?
Jean Louis Vanoverschelde, MD
09.30 - 09.45 Annuloplasty or Not Annuloplasty? A question of standardization
Emanuel Lansac, MD
09.45 - 10.00 Discussion
10.00 - 10.30 Coffee Break & Poster Viewing
10.30 - 12.00 Morning Plenary Session - Degenerative Mitral Valve Disease
Moderators: Rakesh Suri, MD
Maurice Sarano, MD
10.30 - 10.40 Why Patients with Severe Degenerative Mitral Valve Regurgitation Suffer Under Medical Management
Francesco Grigioni, MD
10.40 - 10.45 Discussion
10.45 - 10.55 What are the Clinical Trials Necessary in Degenerative Mitral Valve Disease?
Milind Desai, MD
10.55 - 11.00 Discussion
11.00 - 11.10 Apical Approaches to the Mitral Valve are "Too Little Too Late"
Francesco Maisano, MD
11.10 - 11.15 Discussion
11.15 - 11.25 Robotic Mitral Valve Repair is the New Standard
Danny Ramzy, MD
11.25 - 11.30 Discussion
11.30 - 11.40 Why Patients with Degenerative Mitral Valve Disease Suffer Under SURGICAL Management: Focus on Selecting Surgeons.
Joanna Chikwe, MD
11.40 - 11.45 Discussion
11.45 - 12.00 Panel Discussion
12:00 – 13:30 Industry Lunch Symposium 1
What Mitral Procedures in 5-Year Time? A Rapid Fire Lunch Session
Supported by Edwards Lifesciences
13.30 - 15.00 Concurrent Session I: European Society of Cardiology (ESC) Collaborative Session – The Essentials On The Natural History Of Valve Diseases
Moderators: Maurice Sarano, MD
Madalina Garbi, MD
13.30 - 13.40 Mitral Valve Prolapse
Thierry Le Tourneau, MD, PhD
13.40 - 13.50 Flail Mitral Leaflets
Francesco Grigioni, MD
13.50 – 14.00 Aortic Valve Calcifications
David Messika Zeitoun, MD
14.00 – 14.10 Aortic Stenosis
Joseph Maalouf, MD
14.10 – 14.20 Tricuspid Regurgitation
Yan Topilsky, MD
14.20 – 14.30 Bicuspid Aortic Valve
Hector Michelena, MD
14.30 – 15.00 Discussion
13.30 - 15.00 Concurrent Session II: The Perfect Valve: Mechanical or Biological
Moderators: Hanneke Takkenberg, MD, PhD
Jonathan Butcher, PhD
13.30 - 13.45 The Perfect Valve from an Engineering Perspective
Jonathan Butcher, PhD
13.45 - 14.00 How to Build the Perfect Biological Valve from Scratch: A Toolkit for Dummies
Adrian Chester, PhD
14.00 - 14.15 The Perfect Valve from a Clinician Perspective
Marta Sitges, MD
14.15 - 14.30 Can Mechanical Valves Become Even Better than Perfect?
Walter P Dembitsky, MD
14.30 - 14.45 The Perfect Valve from a Patient Perspective
Hanneke Takkenberg, MD, PhD
14.45 - 15.00 Discussion
13.30 - 15.00 Concurrent Session III: The Future of Imaging: How Do We Assess the Heart?
Moderators: Volkmar Falk, MD
Murat Tuzcu, MD
13.30 - 13.45 CT Planning for TAVI and TMVR
Milind Desai, MD
13.45 - 14.00 4D Real Time Echo Analysis of mitral valve pathology
Thilo Noack, MD
14.00 - 14.15 Image Fusion for Guidance of Mitral Valve Interventions
Jörg Kempfert, MD
14.15 - 14.30 MRI for Valvular Pathology
Robert Manka, MD
14.30 - 15.00 Discussion
13.30 - 15.00 Concurrent Session IV: Heart Valve Repair - Keynote & Abstracts
Moderator: Patrick Perier, MD
13.30 - 13.40 Keynote
Patrick Perier, MD

Presenter is allowed 5 minutes for presentation followed by 3 minutes of discussion and questions
10 Abstracts
A61 Valve Repair Versus Replacement in Isolated Aortic Insufficiency: A Propensity Match Analysis.
Giovanni Battista Luciani, Gianluca Lucchese, Salvatore Torre, Giovanni Benfari, Riccardo Abbasciano, Alessio Rungatscher, Giuseppe Faggian.
University of Verona, Verona, Italy.
A62 Papillary Muscle Head Repositioning for the Treatment of Commissural Prolapse in Degenerative Mitral Valve Disease
Anton Tomsic, Robert J.M. Klautz, Thomas J. van Brakel, Michel I.M. Versteegh, Meindert Palmen.
Leiden University Medical Center, Leiden, Netherlands.
A63 Long-term Results of Posterior Double-suture Annuloplasty for Severe Mitral Regurgitation: A Single-center, Propensity-matched Analysis.
Andrea Garatti, Alberto Canziani, Andrea Daprati, Ali Abu Farah, Francesco Grimaldi, Simone Simeoni, Sonia Tripepi, Lorenzo Menicanti.
IRCCS Policlinico San Donato, San Donato Milanese, Italy.
A64 Transforming Growth Factor-β Genes Are Upregulated And Collagen Synthesis Is Elevated In Mitral Valve Leaflets After Undersizing Mitral Annuloplasty To Repair Ischemic Mitral Regurgitation
Alicja Sielicka, Daniella Espiritu, Weiwei Shi, Vinod H. Thourani, Robert A. Guyton, Eric Sarin, Muralidhar Padala.
Emory University, Atlanta, GA, USA.
A65 100 % Success Rate of Mitral Valve Repair is not Related to the Complexity of the Lesion
Gilles D. Dreyfus1, Filip Dulguerov1, Cecilia Marcacci1, Clara Alexandrescu1, Franck Levy1, Shelley Rahman Haley2, Elie D. Schouver1.
1Cardio Thoracic Center of Monaco, Monaco, Monaco, 2Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.
A66 Adding Annuloplasty Ring to Remodeling Aortic Valve Sparing Repair is Equal to Reimplantation Technique - Insights from in vitro Stress-Strain Characterization
Troels Lading1, Thomas Lindskow1, Tommy Bechsgaard1, Diana M. Røpcke1, Peter Johansen2, Sten L. Nielsen1.
1Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus N, Denmark, 2Department of Engineering, Faculty of Science and Technology, Aarhus University, Aarhus, Denmark.
A67 Development of a Mitral Annuloplasty Ring with Preserved Dynamics of the Annular Height and Remodeling Capacity as Conventional Rigid and Semi Rigid Rings
Søren N. Skov, Diana M. Røpcke, Marcell J. Tjørnild, Christine Ilkjær, Jonas Rasmussen, Hans Nygaard, J M. Hasenkam, Morten O. Jensen, Sten L. Nielsen.
Aarhus University Hospital, Aarhus N, Denmark.
A68 Functional and Structural Differences in Left Ventricular Remodeling in Primary and Secondary Mitral Regurgitation
Daisuke Onohara, Daniella Espiritu, Weiwei Shi, Roberto Hernandez-Merlo, Vinod H. Thourani, Eric L. Sarin, Robert A. Guyton, Muralidhar Padala.
Emory University, Atlanta, GA, USA.
A69 Modified Ross procedure to prevent autograft dilatation: A 5-year experience
Saadallah TAMER, MD, Laurent De Kerchove, MD, PhD, Jawad Hechadi, MD, Philippe Noirhomme, MD, Parla Astarci, MD, PhD, Gebrine El Khoury, MD.
Cliniques Universitaires St-Luc, Woluwe-Saint-Lambert, Belgium.
13.30 - 15.00 Concurrent Session V: Experimental and Computational Valve Tissues Studies Keynote & Abstracts
Moderator: Wei Sun, PhD
13.30 - 13.40 Keynote
Wei Sun, PhD

Presenter is allowed 5 minutes for presentation followed by 3 minutes of discussion and questions
10 Abstracts
A71 Effects of Annuloplasty on In Vivo MV Tissue Stress And Cellular Phenotype
Chung-Hao Lee1, Michael S. Sacks2.
1University of Oklahoma, Norman, OK, USA, 2University of Texas at Austin, Austin, TX, USA.
A72 Alterations in Mechanical Properties and In Vivo Geometry of the Mitral Valve Following Myocardial Infarction
Bruno V. Rego1, Salma Ayoub1, Amir H. Khalighi1, Andrew Drach1, Joseph H. Gorman, III2, Robert C. Gorman2, Michael S. Sacks1.
1University of Texas at Austin, Austin, TX, USA, 2University of Pennsylvania, Philadelphia, PA, USA.
A73 Under What Conditions Do We Find Vortical Flow in the Sinus of Valsalva?
David Hasler1, Bernhard Vennemann2, Stefan Stortecky3, Thomas Pilgrim3, Dominik Obrist1.
1ARTORG Center, University of Bern, Bern, Switzerland, 2Institute of Fluid Dynamics, ETH Zürich, Zürich, Switzerland, 3Department of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.
A74 A Novel Computational Model for Predicting Thrombosis Risk in Bioprosthetic Transcatheter Aortic Valves
Rajat Mittal1, Jung Hee Seo1, Kourosh Shoele1, Jon Resar2.
1Johns Hopkins University, Baltimore, MD, USA, 2Johns Hopkins Hospital, Baltimore, MD, USA.
A75 Biomechanics of Pulmonary Autograft Remodeling: Determining In Vivo Stresses on Autograft Roots at One Year Follow-up
Yue Xuan1, Matt Zweber1, Ismail El-Hamamsy2, Francois Pierre-Mongeon2, Richard L. Leask3, Alexander Emmott3, Aly Ghoneim3, Elaine E. Tseng1, Liang Ge1.
1UCSF Medical Center and San Francisco VA, San Francisco, CA, USA, 2Montreal Heart Institute, Montreal, QC, Canada, 3McGill University, Montreal, QC, Canada.
A76 Bicuspid Aortic Valve Flow Helicity Generates Wall Shear Stress Magnitude And Directionality Abnormalities In Ascending Aortas
Janet Liu, Philippe Sucosky.
Wright State University, Dayton, OH, USA.
A77 Aortic Valve Mechanical, Compositional and Structural Changes with Left-Ventricular Assist Device (LVAD) Implantation
Elizabeth H. Stephens1, Jiho Han1, Emma Trawick1, Elena Dimartino2, Hemanth Akkiraju1, Lewis M. Brown1, K. Jane Grande-Allen3, Jennifer Connell3, Gordana Vunjak-Novakovic1, Hiroo Takayama1.
1Columbia, New York, NY, USA, 2University of Calgary, Calgary, AB, Canada, 3Rice University, Houston, TX, USA.
A78 Valve Sparing Aortic Root Surgery: Preserved Cusp Durability In Reimplantation vs Remodelling Techniques: A Finite Element Analysis
Yaghoub Dabiri, PhD, Janet Ronsky, PhD, Imtiaz Ali, MD, Kishan Narine, MD PhD.
University of Calgary, Calgary, AB, Canada.
A79 In-Vitro Assessment of the Thrombogenic Potential of Heart Valve Prostheses
Benjamin Grossmann, Torsten Linde, Thomas Schmitz-Rode, Ulrich Steinseifer.
RWTH Aachen University, Aachen, Germany.
A80 Patient Specific Numerical Modeling of Diseased Aortic Valve Hemodynamics using Fluid-Structure Interaction Approach
Huseyin C. Yalcin1, Armin Amindari2, Kadir Kirkkopru2, Asma Althani1, Magdi Yacoub3.
1Qatar University Biomedical Research Center, Doha, Qatar, 2Istanbul Technical University, Faculty of Mechanical Engineering, Istanbul, Turkey, 3Faculty of Medicine, National Heart & Lung Institute, Imperial College, London, United Kingdom.
13.30 - 15.00 Concurrent Session VI: BAV: From Molecules to Man
Moderators: Bart Loeys, MD, PhD
Harry Dietz, MD
13.30 - 13.45 Predictors of Bicuspid Aortic Valve Associated Aortopathy in Childhood:
A Report from the MIBAVA Consortium

Michael Grattan, MD
13.45 - 14.00 The Genetic Architecture of Bicuspid Aortic Valve Associated Aortopathy:
Insights From The Mibava Consortium Sequencing

Bart Loeys, MD, PhD
14.00 - 14.30 Lineage-specific Susceptibility to Perturbations of TGF-Β Signaling Drives Syndromic Aortic Aneurysm Formation.
Harry Dietz, MD
14.30 - 14.45 Exploiting Mendelian Contributions to Aortic Valve Disease: from Populations to Mouse Models
Gregor Andelfinger, MD
14.45 - 15.00 Discussion
15.00 - 15.30 Coffee Break & Poster Viewing
15.30 - 16.10 Invited Guest Lectures
Panel: Gilles Dreyfus, MD
Martin Leon, MD
Maurice Sarano, MD
Michael Borger, MD
15.30 - 15.42 The Future of Heart Valve Disease: Challenges and Opportunities
Magdi Yacoub, MD
15:42-15:50 Discussion with Panel
15.50 - 16.02 The Future of Percutaneous Mitral Valve Repair/Replacement: Dream or Reality
David Meerkin, MD
16:02-16:10 Discussion with Panel
16.10 - 17.00 Afternoon Plenary Session
Moderator: Shahbudin H Rahimtoola, MD
16:10 - 16.25 Prosthetic Heart Valves Thrombosis
Shahbudin H Rahimtoola, MD
16.25 - 16.40 Towards a Warfarin Free Mechanical Valve
Walter P Dembitsky, MD
16.40 - 16.55 What is so Different in Between Biological and Mechanical Valves?
Michael Sacks, PhD
17.30 - 18.30 Faculty Reception at the Fairmont (invited faculty only)
SATURDAY, MARCH 4TH
07.00 - 08.00 Education Network Meeting
08.00 - 09.00 Concurrent Session I: HVS Research Networks Updates
Moderators: Maurice Sarano, MD
Hanneke Takkenberg, MD, PhD
08.00 - 09.00 Concurrent Session II: Biomechanics and Mechanobiology / Heart Valve Dysfunction Clinical and Translational
Moderators: Jane Grande-Allen, PhD
Elaine Tseng, PhD
08.00 - 08.10 Aortic Aneurysm Biomechanics
Liang Ge, PhD
08.10 - 08.20 Patient-specific 3D Valve Modeling for Structural Intervention
Stephen Little, PhD
08.20 - 08.30 Computational Modeling of Valve Growth
Sandra Loerakker, PhD
08.30 - 08.40 Transcatheter Aortic Valve Biomechanics
Wei Sun, PhD
08.40 - 08.50 Pulmonary Autograft Biomechanics
Ismail El-Hamamsy, MD, PhD
08.50 - 09.00 Discussion
08.00 - 09.00 Concurrent Session III: Shifting the Paradigm of Mitral Valve Repair: From Minimal Invasive To Microinvasive Surgery
Moderators: Gino Gerosa, MD
Maurizio Taramasso, MD
08.00 - 08.10 Annuloplasty and Leaflet Repair: A Gold Standard in Surgery
Michele De Bonis, MD, FESC
08:10 - 08.20 Transcatheter Mitral Valve Direct Annuloplasty
Maurizio Taramasso, MD
08.20 - 08.30 Transcatheter Neochordae Technologies
Gino Gerosa, MD
08.30 - 08.40 Combining Leaflet and Annular Repair with a Catheter: It is Happening
Maurizio Taramasso, MD
08.40 - 09.00 Discussion
08.00 - 09.00 Concurrent Session IV: Case Session I
Moderator: Jose Pomar, MD

Presenter is allowed 6 minutes for presentation followed by 3 minutes of discussion and questions
C01 Surgical Management Of Aortic Root Abscess And Intervalvular Fibrous Body Reconstruction In Acute Endocarditis
Matteo Pettinari, Gabriele Tamagnini, Roger Devotini, Christiaan Vankerrebroeck, Robert Dion, Herbert Gutermann.
Ziekenhuis Oost Limburg, Genk, Belgium.
C02 Transcatheter Mitral Valve Repair For Severe Mitral Regurgitation Using The HARPOON Device: Six-Month Outcome Case Report
Alison Duncan, Anan Daqa, Mindagas Norkunas, Neil Moat.
The Royal Brompton Hospital, London, United Kingdom.
C03 Prosthetic Tricuspid Valve Endocarditis Treated With Homemade Core-Matrix Valve
Alexander Nagy, M.D., David Gant, PA-C, Paul Gera, M.D..
Monongalia General Hospital, Morgantown, WV, USA.
C04 A Case Series of Percutaneous Aortic Valve Implantation in the Native Mitral Position
Negareh Mousavi, Fahd Makhdom, Joe Martucci, Jean Buithieu, Benoit De Varrennes, Kevin Lachapelle, NIcolo Piazza.
McGill University Health Center, Montreal, QC, Canada.
C05 Unsuccessful Anchoring of Dislocated Symetis Prosthesis with CoreVavle Evolut R resulting in Conventional Aortic Valve Replacement
Elmar Kuhn, Tanja Rudolph, Navid Mader, Thorsten Wahlers.
University Hospital Cologne, Cologne, Germany.
C06 < > Tricuspid Valve Endocarditis in Intra venous drug user : Complex Surgical Reconstruction
Yasir Ahmed, Chiara Proli, Sobaran S. Sharma, Rhodri Davies, Adrian Ionescu, Pankaj Kumar.
Morriston Hospital, Swansea, United Kingdom.
08.00 - 09.00 Concurrent Session V: Heart Failure and Valvular Disease
Moderators: Michael Borger, MD
Anthony DeMaria, MD
08.00 - 08.10 Transcatheter Options for Functional MR: Where’s the Evidence?
Eric Velazquez, MD
08.10 - 08.20 Functional MR in Heart Failure Patients is a Medical Problem, not an Interventional One
Madalina Garbi, MD
08.20 - 08.30 Tricuspid Regurgitation in Heart Failure: New Interventional Horizon or Simply “Bad Marker”?
Jae Won Lee, MD PhD
08.30 - 08.40 How do We Design Heart Failure Trials in the Era of Transcatheter Therapy?
Ori Ben-Yahuda, MD
08.40 - 09.00 Discussion
08.00 - 09.00 Concurrent Session VI: Role of Multimodality Imaging in Structural A-V Valve Interventions
Moderators: Alain Berrebi, MD
Joseph Maalouf, MD
08.00 - 08.10 3D TEE for Planning Mitral Valve Interventions
Marta Sitges, MD
08.10 - 08.20 Multimodality Imaging with CT Scan for Planning Mitral Valve Interventions
Marta Sitges, MD
08.20 - 08.30 Intra-procedural 3D TEE in Percutaneous Mitral Annuloplasty Procedures
David Messika-Zeitoun, MD
08.30 - 08.35 Intra-procedural 3D TEE in Transcatheter Mitral Valve Replacement (TVMR)
Richard Bae, MD
08.35 - 08.40 Intra-procedural 3D TEE in Mitral Valve Procedures: The Clefts and Other Procedural Impediments
Joseph Maalouf, MD
08.40 - 08.50 Imaging in Percutaneous Tricuspid Interventions
Eric Brochet, MD
08.50 - 09.00 Fusion Imaging for All Percutaneous Procedures: What is the Advantage?
09.00 - 10.00 Concurrent Session I: Regenerative Biomaterials for Heart Valve Replacements
Moderators: Katja Schenke-Layland, PhD
Anthal Smits, PhD
08.00 - 08.10 In Situ Heart Valve Tissue Engineering – Seducing the Body to Regenerate
Anthal Smits, PhD
08.10 - 08.20 Heart Valve Guided Tissue Regeneration: From the Preclinical Studies to the First-in-human Implantation
Laura Iop, PhD
08.20 - 08.30 Heart Valve Tissue Engineering - Learning from Nature’s Blueprint
Katja Schenke-Layland, PhD
08.30 - 08.40 A Pulmonary Heart Valve Tissue Engineered from Natural Biomaterials
Claire Brougham, PhD
08.40 - 09.00 Discussion
09.00 - 10.00 Concurrent Session II: Robotic Valve Repair – Unique Challenges
Moderators: Danny Ramzy, MD
Rakesh Suri, MD
09.00 - 09.10 Who Should Have Robotic Mitral Valve Repair
Hector Michelena, MD
09.10 - 09.20 Who Should Perform Robotic Mitral Valve Repair?
Danny Ramzy, MD
09.20 - 09.30 The Latest - Posterior Leaflet Prolapse
Evelio Rodriguez, MD
09.30 - 09.40 The Latest - Anterior and Bileaflet Prolapse
Didier Loulmet, MD
09.40 - 09.50 Mid Term Outcomes Make Robotic Repair the New Standard
Rakesh Suri, MD
09.00 - 10.00 Concurrent Session III: Case Session 2
Moderators: Marta Sitges, MD
Michael Borger, MD

Presenter is allowed 6 minutes for presentation followed by 3 minutes of discussion and questions
C07 Which Mitral Annuloplasty Device Allows Greater Respect for Circumflex Artery? A Case Report of Flow Disturbance.
Vincenzo D. Caruso, Inderpaul Birdi.
Basildon and Thurrock University Hospital, Basildon, United Kingdom.
C08 Sutureless Aortic Valve in a High-Risk Patient Suffering from Staph. aureus Active Infective Endocarditis after Bio-Bentall Surgery
Ahmed Mashhour, MB BCh, Alexander Weymann, PD Dr. med., Albrecht Elsässer, Prof. Dr. med., Pascal M. Dohmen, Prof. Dr. med..
University Hospital Oldenburg, Oldenburg, Germany.
C09 Robotic Repair of Post-Traumatic Tricuspid Regurgitation: a Case Report
Emiliano Navarra, Gebrine El Khoury, Laurent De Kerchove, Philippe Noirhomme.
Cliniques Universitaires St. Luc - UcL - Brussels , Belgium, Brussels, Belgium.
C10 Belt And Braces Technique To Repair Anterior Leaflet Prolapse
Stefano Borsellino, Emiliano Navarra, Stefano Mastrobuoni, Laurent De Kerchove, Philippe Noirhomme, Gebrine El Khoury.
Cliniques Universitaires St. Luc - UcL - Brussels , Belgium, Brussels, Belgium.
C11 Paravalvular Regurgitation After Implantation of a Suturelss Prosthesis Into a Degenerative Homograft
Iakovos Ttofi, Michael Murphy, David Mozalbat, John Pepper, Professor, George Asimakopoulos.
Royal Brompton Hospital, Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom.
C12 Extended Aortic Endocarditis to the Tricuspid Valve : A Trans-aortic Approach
Saadallah TAMER, MD, Laurent De Kerchove, MD, PhD, Philippe Noirhomme, MD, Parla Astarci, MD, PhD, Gebrine El Khoury, MD.
Cliniques Universitaires St-Luc, Woluwe-Saint-Lambert, Belgium.
09.00 - 10.00 Concurrent Session IV: Engineered (Patho)Physiological Heart Valve Models: Replicating the Apollinaire Failure or Failing to Replicate?
Moderators: Petra Mela, PhD
Kartik Balachandran, PhD
09.00 - 09.10 Biohybrid Textile-reinforced Heart Valve Models
Petra Mela, PhD
09.10 - 09.20 In Vitro Models for Valve Fibrosis
Kartik Balachandran, PhD
09.20 - 09.30 A Modular Small Animal Model to Examine the In Vivo Fate of Cardiovascular Implants
Alexander Assmann, MD
09.30 - 09.40 3D Culture Systems for Elucidation of Mechanobiological Mechanisms of Valve Calcification
Jonathan Butcher, PhD
09.40 - 09.50 Tissue-Engineered Heart Valves with the Autoassembly Method
Marc-Antoine Lepage, PhD
09.50 -10.00 Discussion
09.00 - 10.00 Concurrent Session V: Secondary Mitral Valve Regurgitation
Moderators: Gino Gerosa, MD
Khalil Fattouch, MD
09.00 – 09.10 Surgical and Transcatheter Mitral Valve Repair or Replacement for Patients with Secondary MR: Magnitude of Benefit and Prediction of Responders.
Gino Gerosa, MD
09.10 – 09.20 Is Transcatheter Mitral Valve Therapy an Emerging Solution for Secondary MR: Myth or Reality.
Thomas Modine, MD
09.20 – 09.30 Restrictive Annuloplasty Doesn’t Mean Mitral Valve Repair: Why and Who - Can We Improve Results?
Khalil Fattouch, MD
09.30 – 09.40 Is Mitral Valve Replacement the Gold Standard Treatment for Secondary MR? Critical Review of the Literature
Claudio Muneretto, MD
09.40 – 10.00 Discussion
10.00 - 11.00 Closing Plenary Session: Next Steps in Valves: Consensus and Dissension
Moderators: Martin Leon, MD
Gilles Dreyfus, MD
10.00 - 10.30 Debate: Quantification
Topic: Maurice Sarano, MD
Topic: Jean-Louis Vanoverschelde, MD
10.30 - 11.00 Debate: Back to the Future
Topic: Gilles Dreyfus, MD
Topic: Martin Leon, MD