The Heart Valve Society
2019 Program
THURSDAY, 11 APRIL 2019
PLENARY SESSION I
8:00 - 10:00
Presidential Session: Back to the Future
Moderators: Jose Pomar, MD, PhD, Johanna Takkenberg, MD PhD
Discussants: Alain Carpentier, MD, PhD, Alain Cribier, MD, Liesl Zuhlke, MD, PhD, Martin Leon, MD, Magdi Yacoub, MD
8:00 - 8:20
Presidential address
Johanna Takkenberg, MD PhD
8:20 - 8:30
Back to the future: Sitges 1997-Sitges 2018
Jose Pomar, MD, PhD
8:30 - 8:45
Looking back: How has the French correction influenced heart valve therapy?
Alain Carpentier, MD, PhD
8:45 - 9:00
Looking back: Lessons learned from pioneering transcatheter therapy
Alain Cribier, MD
9:00 - 9:15
Looking forward: worldwide access to HVD care in 2039 myth or reality?
Liesl Zuhlke, MD, PhD
9:15 - 9:30
Looking forward: State-of-the-art AV interventions in Sitges 2039
Martin Leon, MD
9:30 - 9:45
Looking forward: Will heart valve tissue engineering have changed the world in 2039?
Magdi Yacoub, MD
9:45 - 10:00
Panel discussion
AORTIC VALVE SESSION I
10:30 - 12:00
Aortic Regurgitation: How to Manage and How to Repair
Moderators: Takashi Kunihara, MD, PhD, Hans J. Schäfers, MD
Discussants: Emmanuel Lansac, MD, PhD, Jeffrey Borer, MD, Milind Desai, MD, Alain Berrebi, MD Hendrik Treede, MD
10:30 - 10:35
Introduction to session
Takashi Kunihara, MD, PhD
10:35 - 10:50
Diameter or Volume? Do We Operate too late?
Milind Desai, MD
10:50 - 11:05
Strain, MRI, Biomarkers, and Exercise Testing: What's New for the Asymptomatic Patients?
Jeffrey Borer, MD
11:05 - 11:20
Roadmap Echo Analysis of AV Reparability
Alain Berrebi, MD
11:20 - 11:40
How to Standardize Aortic Valve Repair?

I Favor Reimplantation (10 minutes)
Laurent de Kerchove, MD, Phd

I Favor Ring Annuloplasty (10 minutes)
Emmanuel Lansac, MD, PhD
11:35 - 11:50
TAVR in Pure AR: Which Patients and Which Valve?
Hendrik Treede, MD
11:50 - 12:00
Discussion
MITRAL VALVE SESSION I
10:30 - 12:00
Degenerative Disease of the Mitral Valve
Moderators: Maurice Sarano, MD, Rakesh Suri, MD, DPhil
Discussants: Thierry Le Tourneau, Md, PhD, Bjorn Skallerud, MSc, Erwan Donal, MD, PhD, Gaetano Thiene, MD, Gregory Fontana, MD
10:30 - 10:40
Do Genes Really Play a Role in the Development of a Mitral Valve Prolapse
Thierry Le Tourneau, MD, PhD
10:40 - 10:50
How does the Mitral Valve Open and Close?
Bjorn Skallerud, MSc
10:50 - 11:00
Assessing Ventricular Function in MR: Fact or Fallacy?
Erwan Donal, MD, PhD
11:00 - 11:10
Sudden Death and MV Prolapse: Another Brick in the Wall for Early Intervention
Gaetano Thiene, MD
11:10 - 11:20
Simplified Techniques for Durable Results
Rakesh Suri, MD, DPhil
11:20 - 11:30
Do You Always Need a Ring when Treating a Mitral Valve Prolapse
Gregory Fontana, MD
11:30 - 12:00
Discussion
VALVE SCIENCE SESSION I
10:30 - 12:00
Valve Development and Growth: Implications for Valve Degeneration and Regeneration
Moderators: Joy Lincoln, PhD, Jordan Miller, PhD
Discussants: Chip Norris, PhD, Dimitris Beis, PhD, Bin Zhou, MD, Deb Henderson, PhD, Danielle Gottlieb-Sen, MD, MPH
10:30 - 10:48
The Contribution of Cilia to Heart Valve Degeneration
Chip Norris, PhD
10:48 - 11:06
Using the Zebrafish Model to Study Heart Valve Regeneration
Dimitris Beis, PhD
11:06 - 11:24
Endothelial Regulation of Heart Valve Defects
Bin Zhou, MD
11:24 - 11:42
Cellular Contributions to Biscuspid Aortic Valve Disease
Deb Henderson, PhD
11:42 - 12:00
Endocardial Cell Plasticity on Heart Valve Development, Disease and Regeneration
Danielle Gottlieb-Sen, MD, MPH
CONGENITAL HVD SESSION I
10:30 - 12:00
The Congenital Aortic Valve Disease: Perspectives from Surgeons, Interventionalists, Scientists and Engineers
Moderators: David Kalfa, MD, PhD, Jane Grande-Allen, PhD
Discussants: Jonathan Butcher, PhD, Chris Baird, MD Peter Hammer, PhD, Susheel Kodali, MD, Giovanni Ferrari, PhD
10:30 - 10:45
Featured Lecture: Biology and Mechanobiology Specific to the Aortic Valve
Jonathan Butcher, PhD
10:45 - 11:05
Debate - Congenital Aortic Valve: Ross and Reinforced Ross or Ozaki??
Ross: David Kalfa, MD, PhD
Ozaki: Chris Baird, MD
11:05 - 11:15
Discussion
11:15 - 11:30
What Can a Mechanical Engineer Bring to a Surgeon to Improve the Duration of an Aortic Valve Repair?
Peter Hammer, PhD
11:30 - 11:45
What Can an Adult Aortic Valve Interventionalist bring to the Pediatric Community to Treat Children and Adult Congenital with Aortic Valve Malformations?
Susheel Kodali, MD
11:45 - 12:00
Degeneration of Bioprothesis in the Pediatric Population
Giovanni Ferrari, PhD
10:30 - 12:00
ABSTRACT SESSION: Cardiac Imaging
Moderator and Introduction to Session:
EURO CTR

Marta Sitges, MD & Luigi Gabrie
 1.
Novel Assessment of Tricuspid Valve Annulus And Papillary Muscle Geometry In Systolic And Diastolic Normal Heart Using 3d Printed Right Ventricular Models
Kazutoshi Tachibana, Shuichi Naraoka, Ryosuke Fujisawa, Shinntaro Sakurada, Koukei Ito, Hiroki Uchiyama.
Hakodate Gryoukaku Hospital, Hakodate, Japan.
 2.
Prognostic Role of Secondary Mitral Regurgitation in Patients with Aortic Valve Stenosis under Medical Follow-up
Giovanni Benfari1, Caterina Maffeis1, Giulia Vinco1, Francesco Onorati2, Riccardo M. Inciardi1, Stefano Nistri3, Flavio L. Ribichini1, Andrea Rossi1.
1Section of Cardiology, Department of Medicine, Verona, Italy, 2Section of Cardiac Surgery, Department of Surgery, Verona, Italy, 3CMSR Veneto Medica, Altavilla Vicentina, Vicenza, Italy.
 3.
Geometrical Correlation Between The Right And Left Ventricular Outflow Tract In Young Bav Vs. Tav Patients: Implications For The Ross Procedure
Shiho Naito, Hermann Reichenspurner, Evaldas Girdauskas.
University Heart Center Hamburg, Hamburg, Germany.
 4.
Changes In Myocardial Work Performance After Surgical And Transcather Aortic Valve Replacement: A Pilot Echocardiographic Study
Srinath Donuru1, Rachad Zayat1, Giulia Musetti2, Nima Hatam1, Rüdiger Autschbach1.
1Department of Thoracic and Cardiovascular Surgery, RWTH University Hospital Aachen, Aachen, Germany, 2General Electric Health care, Solingen, Germany.
 5.
Usefulness of Exercise Echocardiography for Evaluation of Aortic Bioprostheses Under Stress.
Guglielmo Stefanelli1, Fabrizio Pirro, MD1, Clorinda Labia, MD1, Gianpiero Patrizi, MD2, Luca Weltert, MD3, Andrea Barbieri, MD4.
1Hesperia Hospital, Modena, IT, Modena, ITALY, Italy, 2Carpi Hospital, Modena, ITALY, Italy, 3European Hospital, Rome, ITALY, Italy, 4University Hospital, Modena, ITALY, Italy.
 6.
Horizontal Mitral Valve Signal Splay: Limitations of Color Doppler in Transthoracic Echocardiography
Philip C. Wiener, Evan J. Friend, Ruchika Bhargav, Gregg S. Pressman.
Albert Einstein Medical Center, Philadelphia, PA, USA.
 7.
Routine Transthoracic Echocardiogram Alone is Unreliable in Assessing Aortic Valve Calcification
Alicia M. Bonanno, Eric Zimmerman, Giye Choe, Hayden Leeds, Justin J. Watson, Awais Ashfaq, Firas Zahr, Cristina Fuss, Jaishankar Raman.
Oregon Health and Science University, Portland, OR, USA.
 8.
Cardiac Computed Tomography-Guided Sizing of Sutureless Aortic Valves
Kavya Sinha, Moritz C. Wyler von Ballmoos, Pimprapa Vejpongsa, John Mahmarian, Michael J. Reardon, Mahesh K. Ramchandani.
Houston Methodist Hospital, Houston, TX, USA.
12:00 - 1:30
LUNCH - Industry Symposia
12:00 - 1:30
ABSTRACT SESSION: Valve Science
Moderator and Introduction to Session:
Histological Characterization of the Inter-leaflet Triangles

Adrian Chester, PhD & Emily Nordquist
 9.
A New Role For AldosteroneMineralocorticoid Receptor Pathway In Mitral Valve Prolapse
Jaime F. Ibarrola Ulzurrun1, Amaia Garcia de la peña1, Rafael Sadaba1, Vanessa Arrieta1, Virginia Alvarez1, Amaya Fernandez1, Alicia Gainza1, Frederic Jaisser2, Natalia Lopez-Andres1.
1Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain, 2Cordeliers Research Centre INSERM U1138 Team 1, Paris, France.
 10.
Predicting Bioprosthetic Heart Valve Shape, Structure, and Stress with In-vivo Operation
Rana Zakerzadeh, Will Zhang, Michael S. Sacks.
University of Texas at Austin, Austin, TX, USA.
 11.
Aortic Valve Remodelling Is Attenuated In Women With Severe Aortic Regurgitation.
Rafael Sádaba1, Adela Navarro1, Jaime Ibarrola2, Carolina Tiraplegui1, Amaia García-De La Peña1, Vanessa Arrieta1, Virginia Alvarez-Asiain1, Amaya Fernandez-Celis2, Alicia Gainza1, Felix Gomez-Blasco1, Javier De Diego1, Natalia López-Andrés2.
1Complejo Hospitalario de Navarra, Pamplona, Spain, 2NavarraBiomed, Pamplona, Spain.
 12.
GWAS-driven Pathway Analyses and Functional Validation SuggestGLIS1as a Susceptibility Gene for Mitral Valve Prolapse
Mengyao Yu1, Adrien Georges1, Nathan R. Tucker2, Sergiy Kyryachenko1, Patrick T. Ellinor2, David J. Milan2, Russell (Chip) Norris3, Nabila Bouatia-Naji, PhD1.
1INSERM, Paris, France, 2Massachusetts General Hospital, Boston, MA, USA, 3Medical University of South Carolina, Charleston, SC, USA.
 13.
Effect of TAV Implantation Height on Turbulence Intensity in the Ascending Aorta: In vitro study with Tomographic PIV
Leonardo Pietrasanta, David Hasler, Dominik Obrist.
ARTORG Center for Biomedical Engineering Research, University of Bern, Switzerland.
 14.
Bileaflet Mechanical Aortic Valve Prosthesis Orientation Influences Ascending Aortic Blood Flow Patterns
Emile S. Farag1, Luca Peroni2, Lukas M. Gottwald1, Jeroen Vendrik1, S Matthijs Boekholdt1, Aart J. Nederveen1, Pim van Ooij1, Bas AJM de Mol1, Jolanda Kluin1.
1Academic Medical Center, AMSTERDAM, Netherlands, 2LifeTec Group, Eindhoven, Netherlands.
 15.
Chronic Mitral Valve Regurgitation Alters Passive Mechanical Properties of the Left Ventricular Myocardium in a Rodent Model
Daniella Corporan, Vindhyasree Rapolu, Muralidhar Padala.
Emory University, Atlanta, GA, USA.
 16.
Early Osteogenic Mineral Characteristics In Human Valvular Interstitial Cell Culture - Results Of IR-spectroscopy
Alice Mieting1, Gabriel Reimann1, Anett Jannasch1, Katrin Plötze1, Sems Malte Tugtekin1, Klaus Matschke1, Gerald Steiner2, Claudia Dittfeld1.
1Dresden University of Technology, Faculty of Medicine Carl Gustav Carus, Department of Cardiac Surgery, Herzzentrum Dresden, Dresden, Germany, 2Dresden University of Technology, Faculty of Medicine Carl Gustav Carus, Clinical Sensoring and Monitoring, Dresden, Germany.
12:00 - 1:30
VNR MEETINGS
AORTIC VALVE SESSION II
1:30 - 3:00
Aneurysm of the Proximal Aorta: Today and Tomorrow
Moderators: Arturo Evangelista, MD, Ismail El-Hamamsy, MD, PhD, Michael Borger, MD
Discussants: Guillaume Jondeau, MD, Hector Michelena, MD, Maral Ouzounian, MD, PhD, Hans J. Schäfers, MD, Tal Golesworthy, C Eng MEI MRSC, Ourania Preventza, MD, MBA
1:30 - 1:35
Introduction to session
Arturo Evangelista, MD
1:35 - 1:50
Do the diameter-based guidelines still make sense?
Guillaume Jondeau, MD
1:50 - 2:05
How to Predict the Risk Aorta Rupture in Patients with Tricuspid Valve and Bicuspid Valve
Hector Michelena, MD
2:05 - 2:20
Valve Sparing Versus Replacement: What is the Evidence?
Maral Ouzounian, MD, PhD
2:20 - 2:35
Aortic Aneurysm with Bicuspid Aortic Valve: What is the Best Surgery?
Hans J. Schäfers, MD
2:35 - 2:50
When Should the Aortic Arch be Addressed Prophylactically at the Time of Aortic Root Surgery
Ourania Preventza, MD, MBA
2:50 - 3:00
Discussion
TRICUSPID VALVE SESSION I
1:30 - 3:00
The Troublesome Tricuspid Valve
Moderators: Susheel Kodali, MD, Rebecca Hahn, MD
Discussants: Yan Topilsky, MD, Vinod Thourani, MD, João Cavalcante, MD, Gaetano Thiene, MD
1:30 - 1:40
Defining the Magnitude of the TR Problem
Yan Topilsky, MD
1:40 - 1:45
Discussion
1:45 - 1:55
The Complex Tricuspid Valve Anatomy: Knowing is Seeing
Gaetano Thiene, MD
1:55 - 2:05
Quantitative Imaging of the Right Heart and Tricuspid Valve: Seeing is Knowing
João Cavalcante, MD
2:05 - 2:10
Discussion
2:10 - 2:15
Case presentation: Pacer TR
Karima Addetia, MD
2:15 - 2:25
Pacer TR: Diagnosis and Management
Denisa Muraru, MD. PhD
2:25 - 2:30
Case presentation: Functional TR
Alberto Pozzoli, MD
2:30 - 2:40
The Tricuspid-Right Heart-Pulmonary Vascular Connection
Rebecca T. Hahn, MD
2:40 - 2:45
Discussion
2:45 - 2:55
Can Anatomy and Physiology Help Us Determine Treatment for TR?
Vinod Thourani, MD
2:55 - 3:00
Discussion
VALVE SCIENCE SESSION II
1:30 - 3:00
Imaging and Computational Design to Advance Valvular Therapy
Moderators: Michael Sacks, PhD, Elaine Tseng, MD
Discussants: Elaine Tseng, MD, Joseph Maalouf, MD, Ajit Yoganathan, PhD, Sandra Loerakker, PhD
1:30 - 1:48
Patient Specific Experimental and Computational Modeling of Transcatheter Aortic Valves
Elaine Tseng, MD
1:48 - 2:06
Impact of Different Monocusp Valve Designs on Hemodynamics in the Pulmonary Artery: a Computational Investigation'
Sandra Loerakker, PhD
2:06 - 2:24
Patient Specific Computational Modeling of the Mitral Valve to Tailor Valve Therapy
Michael Sack, PhD
2:24 - 2:42
3D imaging for Catheter based Valve Interventions
Joseph Maalouf, MD
2:42 - 3:00
How Does Valve Design Affect Postsurgical Valve Mechanics?
Ajit Yoganathan, PhD
SPECIAL TOPIC SESSION I
1:30 - 3:00
The Neglected Mitral Valve Disease: A Chronic Need to be Addressed
Moderators: Liesl Zuhlke, MD, Jose Pomar, MD, PhD
Discussants: Yannick Taverne, MD, Mohammed Khalil, MD, Hector Michelena, MD, Samir Kapadia MD, Daniel Pereda, MD
1:30 - 1:40
The Normal and the Abnormal Development of the Mitral Valve
Yannick Taverne, MD
1:40 - 1:50
Congenital Mitral Valve Lesions: Correlation Between Morphology and Imaging
Mohammed Khalil, MD
1:50 - 2:00
Degenerative Mitral Valve Stenosis: A New Challenge
Hector Michelena, MD
2:00 - 2:10
Rheumatic Mitral Valve Disease: Opportunities for Intervention, Innovation and Care
Liesl Zuhlke, MD
2:10 - 2:20
The Heart Team In Action: What is Needed in Rheumatic Heart Disease Management?
Samir Kapadia MD
2:20 - 2:30
Mitral Valve Endocarditis: Innovative Surgical Therapies to Repair Infected Valves
Daniel Pereda, MD
2:30 - 3:00
Discussion
1:30 - 3:00
ABSTRACT SESSION: Surgical Aortic Valve
Moderator and Introduction to Session:
Aortic Valve Surgery for Aortic Regurgitation

Jeffrey Borer, MD
 17.
Aortic Valve Repair Improve Patients Outcomes Compare to Mechanical Valve Replacement: 4 years Results of the CAVIAAR Multicentric Trial
Emmanuel Lansac1, Isabelle Di Centa2, Olivier Bouchot1, Eric Arnaud Crozat3, Rachid Hacini3, Fabien Doguet4, Roland Demaria5, Jean Philippe Verhoye6, Jerome Jouan7, Didier Chatel8, Stephane Lopez9, Thierry Folliguet10, Christophe ACAR11, Pascal Leprince11, Thierry Languanay12, Bernard Alba5, Jean Francois Obadia13, christian Latremouille7, Georges Fayad14, Jean Pierre Fleury3, Alexande Lafourcade11, Mathieu Debauchez1, Florence Tubach11.
1Institut Mutualiste Montsouris, PARIS, France, 2Hopital Foch, Suresnes, France, 3CHU Belledone, Grenoble, France, 4CHU Rouen, Rouen, France, 5CHU Montpellier, Montpellier, France, 6CHU Rennes, Rennes, France, 7HEGP, PARIS, France, 8clinique St Gatien, Tours, France, 9Centre Arnaud Tzank, Nice, France, 10CHU Henri Mondor, Creteil, France, 11CHU Pitié Salpétrière, PARIS, France, 12CHU Rennes, PARIS, France, 13CHU LYON, Lyon, France, 14CHU Lille, Lille, France.
 18.
Symmetric Bicuspidization and Annuloplasty Provide a Functioning Valve Configuration to Unicuspid Aortic Valve
Shunsuke Matsushima, MD, Takashi Igarashi, MD, PhD, Atsushi Shimizu, MD, Tristan Ehrlich, MD, Irem Karliova, MD, Hans-Joachim Schäfers, MD, PhD.
Saarland University Medical Center, Homburg/Saar, Germany.
 19.
Isolated Bicuspid Aortic Valve Repair in the Current Era - Annuloplasty Leads to Improved Mid-term Stability
Ulrich Schneider, MD, Irem Karliova, MD, Christian Giebels, MD, Tristan Ehrlich, MD, Hans-Joachim Schäfers, MD.
Saarland University Medical Center, Homburg, Germany.
 20.
Long Term Clinical and Echocardiographic Outcome In Middle Aged Patients Undergoing The Ross Procedure
Jamie Romeo, MD MSC1, Grigorios Papageorgiou, MSC1, Francisco da Costa, MD PHD2, Hans Sievers, MD PHD3, Ad Bogers, MD PHD1, Ismail el-Hamamsy, MD PHD4, Peter Skillington, MD PHD5, Rochelle Wynne, MD PHD5, Stefano Mastrobuoni, MD PHD6, Gebrine El Khoury, MD PHD7, Johanna Takkenberg, MD PHD1, Mostafa Mokhles, MD PHD1.
1Erasmus Medical Centre, Rotterdam, Netherlands, 2Department of Cardiac Surgery, Santa Casa de Curitiba, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil, 3Department of Cardiac and Thoracic Vascular Surgery, University of Lübeck, Lübeck, Germany, 4Cardiovascular Surgery, CHU Sainte Justine, Montreal, Canada, Montreal, QC, Canada, 5Department of Cardiothoracic Surgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia, 6Department of Cardiovascular and Thoracic Surgery, Saint Luc University Clinic, Brussels, Belgium, 7Department of Cardiovascular and Thoracic Surgery, St Luc's Hospital, Catholic University of Louvain, Brussels, Belgium.
 21.
Effect of Prosthesis-Patient Mismatch On Early and Late Mortality in Low Risk Isolated Aortic Valve Replacement
Walid Elmahdy, Mohamed Osman, Mohamed Farag, Haisam Saad, Marius Berman.
Royal Papworth Hospital NHS Foundation Trust, Cambridgeshire, United Kingdom.
 22.
Five-year Outcomes Of Aortic Valve Replacement Using A Bioprosthetic Valve With The Novel Resilia Tissue: Final Study Results
Krysztof Bartus1, Agata Bilewska2, Maciej Bochenek1, Maciej Stapor3, Radoslaw Litwinowicz3, Jacek Rozanski2, Jerzy Sadowski1, Boguslaw Kapelak1, Mariusz Kusmierczyk1.
1Jagiellonian University, John Paul II Hospital, Krakow, Poland, 2Institute of Cardiology, Warsaw, Poland, 3John Paul II Hospital, Krakow, Poland.
 23.
Ross Procedure in Neonate and Infant Populations: A Meta-analysis Review
Scarlett Tohme1, Shangqing Jiang2, Amee Shah3, Lindsay Freud3, Giovanni Ferrari3, Emile Bacha3, David Kalfa3.
1New York Medical College, Valhalla, NY, USA, 2Columbia University Mailman School of Public Health, New York, NY, USA, 3Columbia University College of Physicians and Surgeons New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA.
 24.
Sutureless Valve in Aortic Valve Reoperation: Results from an International Prospective Registry
Mattia Glauber1, William Kent2, George Asimakopoulos3, Giovanni Troise4, Josep Maria Padrò5, Alistair Royse6, Jean-Marc Marnette7, Philippe Noirhomme8, Max Baghai9, Michael Lewis10, Antonio Miceli1, Lorenzo Di Bacco1, Marco Solinas11.
1Istituto Clinico Sant'Ambrogio, Milano, Italy, 2Libin Cardiovascular Institute and University, Calgary, AB, Canada, 3Royal Brompton Hospital, London, United Kingdom, 4Fondazione Poliambulanza, Brescia, Italy, 5Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, 6Royal Melbourne Hospital, Melbourne, Australia, 7CHR de Namur, Namur, Belgium, 8Saint Luc University Clinic, Brussels, Belgium, 9King's College Hospital, London, United Kingdom, 10Brighton and Sussex University Hospitals, Sussex, United Kingdom, 11Pasquinucci Heart Hospital, Massa, Italy.
3:00 - 3:30
BREAK
PLENARY SESSION II
3:30 - 5:30
The Era of the Atrioventricular Valve
Moderators: Rakesh Suri, MD, DPhil, Vinod Thourani, MD
Discussants: Yannick Taverne, MD Didier Loulmet, MD, Joerg Kempfert, MD, Gilles Dreyfus, MD, Jeffrey Borer, MD, Maurizio Taramasso, MD
3:30 - 3:40
How does the leaflet and annular anatomy of the mitral and tricuspid valves differ
Yannick Taverne, MD
3:40 - 3:50
Discussion
3:50 - 4:00
What are the advantages of contemporary minimally invasive surgical approaches to the mitral valve?
Didier Loulmet, MD
4:00 - 4:10
Discussion
4:10 - 4:20
How well does percutaneous mitral valve repair emulate surgical correction?
Joerg Kempfert, MD
4:20 - 4:30
Discussion
4:30 - 4:40
Functional TR Surgery: When, Why, How?
Gilles Dreyfus, MD
4:40 - 4:50
Discussion
4:50 - 5:00
Which approaches to percutaneous tricuspid valve repair are most effective?
Jeffrey Borer, MD
5:00 - 5:10
Discussion
5:10 - 5:20
Is a combined percutaneous approach to the mitral and tricuspid valves the future therapy of choice for degenerative mitral valve disease?
Maurizio Taramasso, MD
5:20 - 5:30
Discussion
5:20 - 5:30
Poster Competition & Welcome Reception at the Melia Hotel

FRIDAY, 12 APRIL 2019
6:15 - 5:30
Attendee Registration - Hall Auditorium
6:15 - 5:30
Speaker Ready - Mestral 1
6:30 - 8:00
Industry Breakfast Symposia
PLENARY SESSION III
8:00 - 10:00
Battle of the Giants
Moderators: Rakesh Suri, MD, DPhil, Ourania Preventza, MD, MBA
Discussants: Blasé Carabello, MD, Jean François Obadia, MD, PhD, Magdi Yacoub, MD, Patrick Serruys, MD, Murat Tuzcu, MD, Marta Sitges, MD, Joanna Chikwe, MD
8:00 - 8:30
COAPT
Blasé Carabello, MD vs. Jean François Obadia, MD, PhD
8:30 - 9:00
Surgical Tissue Engineered vs. Transcatheter Bovine Pericardial Valves - Whic One Will Dominate in 2031
Magdi Yacoub, MD vs. Patrick Serruys, MD
9:00 - 9:30
Re-do AVR V. Valve in Valve TAVR - What Does the Science Say in 2018?
Murat Tuzcu, MD vs. Ourania Preventza, MD, MBA
9:30 - 10:00
Imaging Does Not Influence Timing Of Degenerative Mitral Valve Repair
Marta Sitges, MD vs. Joanna Chikwe, MD
AORTIC VALVE SESSION III
10:30 - 12:00
Hot Topics in Aortic Stenosis
Moderators: Blasé Carabello, MD, Philippe Généreux, MD
Discussants: George Thanassoulis, MD, Marie-Annick Clavel, DVM, PhD, Howard Herrman, MD, Nicolas Van Mieghem, MD
10:30 - 10:35
Introduction to session:
Philippe Pibarot, DVM, PhD
10:35 - 10:50
From Genomics to Hope in the Pharmacological Treatment
George Thanassoulis, MD
10:50 - 11:05
Male-female Differences in Pathophysiology, Outcome and Management
Marie-Annick Clavel, DVM, PhD
11:05 - 11:20
Algorithm for the Management of Low Gradient Aortic Stenosis
Howard Herrmann, MD
11:20 - 11:35
Moderate Aortic Stenosis with HFrEF
Nicholas Van Mieghem, MD
11:35 - 11:50
Debate - Asymptomatic Severe Aortic Stenosis: What is the Best Management?

Early AVR (7 min)
Philippe Généreux, MD

Clinical surveillance (7 min)
Blasé Carabello, MD
11:50 - 12:00
Discussion
MITRAL VALVE SESSION II
10:30 - 12:00
Functional Mitral Regurgitation: The Ongoing Controversy
Moderators: Marta Sitges, MD, Marc Gillinov, MD
Discussants: Jerry Braun, MD, PhD, Morten O. Jensen, DrMed, PhD, Resham Barauh, MD, Michael Borger, MD, Vinod Thourani, MD, Mark Ratcliffe, MD
10:30 - 10:40
Sense and Nonsense of FMR
Jerry Braun, MD, PhD
10:40 - 10:50
Biomechanical Aspects of FMR
Morten O. Jensen, DrMed, PhD
10:50 - 11:00
Management of AF in the Mitral Patient
Marc Gillinov, MD
11:00 - 11:10
The Landscape of Transcatheter Repair Therapies to Treat Functional Mitral Regurgitation: Will these Change our Clincal Approach?
Michael Borger, MD
11:10 - 11:20
What is the Future of the Treatment of FMR: from Interventional Treatments to Tissue Therapy?
Vinod Thourani, MD
11:20 - 11:30
Ventricular-valve Interactions with FMR - State of the Art
Mark Ratcliffe, MD
11:30 - 12:00
Discussion
VALVE SCIENCE SESSION III
10:30 - 12:00
The Biology of Calcific Valve Disease
Moderators: Joy Lincoln, PhD, Katherine Yutzey, PhD
Discussants: Sergio Bertazzo, PhD, Craig Simmons, PhD, Cynthia St. Hilaire, PhD, Patrick Mathieu, MD, MSc
10:30 - 10:48
The Molecular Regulation of Heart Valve Calcification
Katherine Yutzey, PhD
10:48 - 11:06
Imaging and Calcific Aortic Valve Disease
Sergio Bertazzo, PhD
11:06 - 11:24
The Mechanoregulation of Calcific Aortic Valve Disease
Craig Simmons, PhD
11:24 - 11:42
Cellular Phenotypes in Vascular and Valve Calcification
Cynthia St. Hilaire, PhD
11:42 - 12:00
Lipoproteins and Calcific Aortic Valve Disease
Patrick Mathieu, MD, MSc
SPECIAL TOPIC SESSION II
10:30 - 12:00
LET'S TALK ABOUT SEX: Sex-Differences in Heart Valve Disease
Moderators: Mostafa Mokhles, MD, PhD, LL.M, Jordan Miller, PhD
Discussants: Marie-Annick Clavel, DVM, PhD, Rebecca Hahn, MD, Johanna Takkenberg, MD, PhD
10:30 - 10:48
Pathophysiology of Valvular Heart Disease: What is the Effect of Sex?
Marie-Annick Clavel, DMV, PhD
10:48 - 11:06
Does Pregnancy Influence the Outcome of Patients with a Prosthetic Heart Valve or Homograft?
Mostafa Mokhles, MD, PhD, LL.M
11:06 - 11:24
Effect of Sex After Transcatheter Aortic Valve implantation
Rebecca Hahn, MD
11:24 - 11:42
Sex Related Differences in Clinical Presentation and Outcome of Surgical Aortic Valve Replacement
Jordan Miller, PhD
11:42 - 12:00
Risk Score Development for Patients in Need of Heart Valve Intervention- Should it Be Bex Specific?
Johanna Takkenberg, MD, PhD
10:30 - 12:00
ABSTRACT SESSION: Transcatheter Therapies
Moderator and Introduction to Session:
Are We Ready for Transcatheter Pulmonary Valve Replacement in Native Right Ventricular Outflow Tract?

Carlos Ruiz, MD & Ignacio Cruz Gonzales
 25.
Analysis of Length of Hospital Stay after Transfemoral Transcatheter Aortic Valve Implantation: Results from the FRANCE TAVI (French Transcatheter Aortic Valve Implantation) Registry
Eric Durand1, Guillaume Avinée1, Christophe Tron1, Martine Gilard2, Jean Philippe Verhoye3, René Koning4, Thierry Lefevre5, Eric Van Belle6, Pascal Leprince7, Bernard Iung8, Hervé Le Breton3, Helene Eltchaninoff1.
1CHU de Rouen, Rouen, France, 2CHU de Brest, Brest, France, 3CHU de Rennes, Rennes, France, 4Clinique Saint Hilaire, Rouen, France, 5Institut Hospitalier Jacques Cartier, Massy, France, 6CHU de Lille, Lille, France, 7Pitie Sapetriere Hospital, Paris, France, 8Bichat Hospital, Paris, France.
 26.
Assessment of Long-Term Structural Deterioration of Transcatheter Aortic Bioprosthetic Valves Using The New European Definition: a Multicenter French Study
Eric Durand1, Anastasia Sokoloff1, Marina Urena-Alcazar2, Bernard Chevalier3, Stephan Chassaing4, Romain Didier5, Christophe Tron1, Pierre-Yves Litzler1, Claire Bouleti2, Dominique Himbert2, Thomas Hovasse3, Olivier Bar4, Guillaume Avinée1, Bernard Iung6, Didier Blanchard4, Martine Gilard5, Alain Cribier1, Thierry Lefevre1, Helene Eltchaninoff1.
1CHU de Rouen, Rouen, France, 2Bichat Hospital, Paris, France, 3Institut Hospitalier Jacques Cartier, Massy, France, 4Clinique Saint Gatien, Tours, France, 5CHU de Brest, Brest, France, 6Bichat Hospital, Rouen, France.
 27.
Impact of BASILICA on Sinus and Neo-sinus Washout after Transcatheter Aortic Valve-in-Valve
Hoda Hatoum1, Pablo Maureira2, Scott Lilly1, Lakshmi Prasad Dasi1.
1The Ohio State University, Columbus, OH, USA, 2Centre Hospitalier Universitaire de Nancy, Laxou, France.
 28.
Neo-sinus Flow Stasis Correlates with Thrombus Volume in Patients post-TAVR
Phillip M. Trusty1, Vahid Sadri1, Immanuel David Madukauwa-David1, Emelia Funnell1, Norihiko Kamioka2, Rahul Sharma3, Raj Makkar3, Vasilis Babaliaros2, Ajit P. Yoganathan1.
1Georgia Institute of Technology, Atlanta, GA, USA, 2Emory University School of Medicine, Atlanta, GA, USA, 3Cedars-Sinai Heart Institute, Los Angeles, CA, USA.
 29.
Passive Beating Heart Platform for Testing, Training and Teaching of Transcatheter Therapies
Matthias F. Menne1, Benjamin Grossmann2, Thomas Schmitz-Rode3, Ulrich Steinseifer1.
1Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, RWTH Aachen University, Aachen, Germany, 2ac.biomed GmbH, Aachen, Germany, 3Institute of Applied Medical Engineering, RWTH Aachen University, Aachen, Germany.
 30.
The Progression of Transcatheter Valve replacement: An Option in Deteriorating Bioprosthetic Valves
Elizabeth K. Walsh, Elizabeth Cichonski, Nimesh Desai, MD, Saif Anwarrudin, MD, Wilson Szeto, MD, Robert Li, MD, Prashanth Vallabhajosyula, MD, Jay Giri, Matthew Williams, MD, Howard Herrmann, MD, Joseph Bavaria, MD.
The University of Pennsylvania Hospital, Philadelphia, PA, USA.
 31.
Comparison of Tug Force, Leakage and Resheathing Behaviour of Two LAA Occlusion Systems: An In-vitro Study
Matthias F. Menne1, Jan W. Schrickel2, Georg Nickenig2, Baravan Al-Kassou2, Dominik Nelles2, Thomas Schmitz-Rode1, Ulrich Steinseifer3, Alexander Sedaghat2.
1Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Aachen, Germany, 2Medizinische Klinik und Poliklinik II - Cardiology, Universitätsklinikum Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany, 3Monash Institute of Medical Engineering and Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, Australia.
 32.
Stent and Leaflet Stresses In 26-mm, Second-generation, Self-expandable Transcatheter Aortic Valve
Zhongjie Wang1, Yue Xuan1, Andrew Wisneski1, Danny Dvir2, Jian Ye3, Julius M. Guccione1, Liang Ge1, Elaine E. Tseng1.
1UCSF Medical Center and San Francisco VA Medical Center, San Francisco, CA, USA, 2University of Washington, Seattle, WA, USA, 3St Paul's Hospital, Vancouver, BC, Canada
12:00 - 1:30
LUNCH - Industry Symposia
12:00 - 1:30
ABSTRACT SESSION: Tissue Engineering & Epidemiology
Moderator and Introduction to Session:
Advances and Hurdles in Creating One Valve for Life

Jolanda Kluin, MD, PhD & Jan Willem van Rijswijk
 33.
Aortic Root Geometry In Patients With A Unicuspid Aortic Valve Disease: Comparison With A Bicuspid And Tricuspid Aortic Valve Entity
Shiho Naito, Hermann Reichenspurner, Evaldas Girdauskas.
University Heart Center Hamburg, Hamburg, Germany.
 34.
What is the View of Cardiologists and Cardiothoracic Surgeons in the Heart Valve Society Community on Shared Decision-Making?
Jantine J. Lindeboom1, Megan Coylewright2, Jonathan R.G. Etnel1, Anna P. Nieboer3, Joost M. Hartman4, Johanna J.M. Takkenberg1.
1Department of Cardiothoracic Surgery, Erasmus University Medical Center, Rotterdam, Netherlands, 2Department of Cardiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA, 3Erasmus School of Health Policy and Management, Erasmus University, Rotterdam, Netherlands, 4Department of Cardiothoracic surgery, University Medical Center, Groningen, Netherlands.
 35.
Average Density of The Psoas Muscle Detected By Multislice Computed Tomography As A Measure of Fragility In Patients Candidates For Transcatheter Aortic Valve Replacement
Romina E. Trossero, Maria F. Castro, Agustina Sciancalepore, Paola Kuschnir, Teresa Politti, Maria P. Ricapito, Ricardo Ronderos.
ICBA, Ciudad Autonoma Buenos Aires, Argentina.
 36.
Male-Female Differences in Long-term Mortality after Ascending Aortic Surgery
Arjen L. Gökalp, Kelly Voigt, Carlijn G.E. Thijssen, Jolien W. Roos-Hesselink, Ad J.J.C. Bogers, Johanna J.M. Takkenberg, Mostafa M. Mokhles, Jos A. Bekkers.
Erasmus Medical Center, Rotterdam, Netherlands.
 37.
What is the Potential Cost-Effectiveness of Tissue-Engineered Heart Valves?
Simone A. Huygens1, Maureen P.M.H. Rutten-van Mölken2, Anahita Noruzi1, Jonathan R.G. Etnel1, Isaac Corro Ramos3, Carlijn V.C. Bouten4, Jolanda Kluin5, Johanna J.M. Takkenberg1.
1Erasmus MC, Rotterdam, Netherlands, 2Erasmus School of Health Policy & Management, Rotterdam, Netherlands, 3Institute for Medical Technology Assessment, Erasmus University Rotterdam, Rotterdam, Netherlands, 4Eindhoven University of Technology, Eindhoven, Netherlands, 5Amsterdam Medical Centre, Amsterdam, Netherlands.
 38.
Long Term Effect of Scaffold Fiber Orientation on In-Situ Tissue Engineered Heart Valves
M. Uiterwijk1, A.I.M.P. Smits2, D. van Geemen3, B. van Klarenbosch4, S. Dekker3, J.W. van Rijswijk1, E.B. Lurier3, M.C.P. Brugmans5, M.J. Cramer4, A.W. Bosman6, P.F. Grundeman7, C.V.C. Bouten2, J. Kluin1.
1Amsterdam University Medical Center, Amsterdam, Netherlands, 2Eindhoven University of Technology, Department of Biomedical Engineering & Institute for Complex molecular Systems, Eindhoven, Netherlands, 3Eindhoven University of Technology, Department of Biomedical Engineering, Eindhoven, Netherlands, 4University medical center Utrecht, div. Heart & Lungs - Cardiology, Utrecht, Netherlands, 5Xeltis BV, Eindhoven, Netherlands, 6Suprapolix BV, Eindhoven, Netherlands, 7University medical center Utrecht, Exp. Cardiology Laboratory, Netherlands. PLA Medical School, Beijing, China.
 39.
Bone Marrow Mononuclear Cell Preseeding on Bioresorbable Elastomeric Tissue Engineered Heart Valves for Transcatheter Pulmonary Valve Replacement: a Word of Caution.
Emanuela S. Fioretta1, Valentina Lintas1, Matilde Putti2, Sarah E. Motta1, Anthal I. Smits2, Petra E. Dijkman1, Nikola Cesarovic3, Etem Caliskan3, Hector Rodriguez3, Henk M. Janssen4, Serge H. Söntjens4, Carlijn V. Bouten2, Maximilian Y. Emmert1, Simon P. Hoerstrup1.
1University of Zurich, Zurich, Switzerland, 2Eindhoven University of Technology, Eindhoven, Netherlands, 3University Hospital Zurich, Zurich, Switzerland, 4SyMO-Chem B.V., Eindhoven, Netherlands.
12:00 - 1:30
VRN MEETINGS
AORTIC VALVE SESSION IV
1:30 - 3:00
TAVR Versus SAVR
Moderators: Hélène Eltchaninoff, MD, Vinod Thourani, MD, Murat Tuzcu, MD
Discussants: Philippe Pibarot, DVM, PhD, Martin Leon, MD, Linda Gillam, MD, MPH, Danny Dvir, MD, Sabine Bleiziffer, MD
1:30 - 1:35
Introduction to session: The State of the Volume in TAVR vs. SAVR
Vinod Thourani, MD
1:35 - 1:50
Paravalvular Regurgitation and Prosthesis-Patient Mismatch: TAVR vs. SAVR
Philippe Pibarot, DVM, PhD
1:50 - 2:05
Bioprosthetic Thrombosis: TAVR vs. SAVR
Gregory Fontana, MD
2:05 - 2:20
Viewpoint - Low Surgical Risk: TAVR vs. SAVR

Based Upon Recent Clinical Trial Evidence, I Would Favor Using TAVR in Many Low-Risk Patients

Martin Leon, MD

Based Upon Past and Recent Evidence, I Would Favor Using SAVR in Most Low-Risk Patients
Linda Gillam, MD, MPH
2:20 - 2:35
Valve Durability: TAVR vs. SAVR
Hélène Eltchaninoff, MD
2:35 - 2:50
Transcatheter Valve-in-Valve Versus Redo Surgery for Failed Surgical Bioprosthetic Valves

Pro: Valve-in-Valve is the Standard of Care Regardless of Surgical Risk

Danny Dvir, MD

Con: Valve-in-Valve Only in Patients with High Surgical Risk
Sabine Bleiziffer, MD
2:50 - 3:00
Discussion
TRICUSPID VALVE SESSION II
1:30 - 3:00
Tricuspid Regurgitation Treatment: A Work in Progress
Moderators: Yan Topilsky, MD, Mark Reisman, MD, FACC
Discussants: Michele De Bonis, MD, Marta Sitges, MD
1:30 - 1:40
What the Guidelines Do and Don't Tell Us
Yan Topilsky, MD
1:40 - 1:45
Discussion
1:45 - 1:55
Surgery for TR: Current Approaches and Outcomes
Michele De Bonis, MD
1:55 - 2:00
Case of Torrential TR
Marta Sitges, MD
2:00 - 2:10
Learning from Our Mistakes: Who should and shouldn't be treated in the era of transcatheter devices?
Susheel Kodali, MD
2:10 - 2:15
Discussion
2:15 - 2:22
Current Outcomes of Transcatheter TR Therapies: Results from the International TriValve Registry
Maurizio Taramasso, MD
2:22 - 2:29
Lessons in durability from surgical correction of functional TR
Gilles Dreyfus, MD
2:29 - 2:36
Tricuspid Closers: Clips and Spacers
Neil Fam, MD, MSc
2:36 - 2:41
Caval Valve Implants: do they work?
Michael Laule, MD
2:41 - 2:48
Transcatheter Tricuspid Valve Replacement: the promise and pitfalls
Rebecca Hahn, MD
2:48 - 2:55
Tricuspid Tissue Engineering: the New Frontier
Maximilian Emmert, MD, PhD
2:55 - 3:00
Discussion
VALVE SCIENCE SESSION IV
1:30 - 3:00
VALVE TISSUE ENGINEERING: Do We Understand Variability in Outcomes?
Moderators: Carlijn Bouten, PhD, Adrian Chester, PhD
Discussants: Anthal Smits, PhD, Simon Hoerstrup, MD, PhD, Jane Grande Allen, PhD
1:30 - 1:48
Variability in Heart Valve Tissue Engineering Outcomes in Vivo: Cause and Consequences
Simon Hoerstrup, MD, PhD
1:48 - 2:06
How scaffold processing variables affect engineered heart valve morphology and mechanics
Antonio D'Amore, PhD
2:06 - 2:24
In-Situ Material-Based Valve Tissue Engineering; The Host Dictates the Outcomes
Anthal Smits, PhD
2:24 - 2:42
Heterogeneity in cells for tissue engineering; Relevance for Predicting Tissue Engineering Outcomes?
Najma Latif, PhD
2:42 - 3:00
Functional Markers of Heart Valve Tissue Regeneration and Degeneration
Zeeshan Syedan, PhD
CONGENITAL HVD SESSION II
1:30 - 3:00
The Congenital Mitral Valve Disease: Perspectives from Surgeons, Interventionalists, Scientists and Engineers
Moderators: Michael Sacks, PhD, David Kalfa, MD, PhD,
Discussants: Jane Grande-Allen, PhD, Alain Carpentier, MD, PhD, Murali Padala, PhD, Peter Hammer, PhD
1:30 - 1:45
Featured Lecture: Biology and Mechanobiology Specific to the Mitral Valve
Jane Grande-Allen, PhD
1:45 - 2:00
Featured Lecture: How I Approach the Congenital Mitral Valve Repair
Alain Carpentier, MD, PhD
2:00 - 2:30
Debate - Unrepairable Congenital Mitral Valve: Mechanical, Melody or Cylinder Replacement?


Mechanical: Emre Belli, MD
Melody: David Kalfa, MD, PhD
Cylinder: Rene Pretre, MD
2:30 - 2:40
Discussion
2:40 - 2:50
Computational Modeling and Mitral Valve Surgery
Murali Padala, PhD
2:50 - 3:00
What it takes to Develop a Growing Ring Device in Children
Peter Hammer, PhD
1:30 - 3:00
ABSTRACT SESSION: Surgical Mitral Valve
Moderator and Introduction to Session:
Why Right Thoracotomy is the Incision of Choice

Michael Borger, MD
 41.
Tricuspid Valve Regurgitation is a Risk Factor for Worsening of Ejection Fraction after Minimally Invasive Surgery for Primary Mitral Valve Regurgitation
Yukiharu Sugimura, MD, Shintaro Katahira, MD, PhD, Moritz B. Immohr, MD, Philipp Rellecke, MD, Jan P. Minol, MD, Patrick Horn, MD, PhD, Ralf Westenfeld, MD, PhD, Hug Aubin, MD,PhD, Alexander Albert, MD, PhD, Artur Lichtenberg, MD,PhD, Payam Akhyari, MD, PhD.
Heinrich Heine University, Dusseldorf, Germany.
 42.
Left Ventricular Dysfunction After Minimally Invasive Mitral Valve Surgery In Asymptomatic Patients: Risk Factors Analysis
Giacomo Bianchi, MD, PhD, Silvia Di Sibio, MD, Rafik Margaryan, MD, PhD, Marco Solinas, MD.
Ospedale del Cuore - Fondazione Toscana, Massa, Italy.
 43.
A Structured Approach to Native Mitral Valve Infective Endocarditis: Is Repair Better than Replacement?
Rufin J. Defauw, MD, Anton Tomšic, MD, Thomas J. van Brakel, MD PhD, Nina Ajmone Marsan, MD PhD, Robert J.M. Klautz, MD PhD, Meindert Palmen, MD PhD.
Leiden University Medical Center, Leiden, Netherlands.
 44.
Comparing the Use of the Melody Valve and Mechanical Valves for Pediatric Mitral Valve Replacement
Anna Olds, Brigitte Kazzi, Matthew Liava'a, Matthew A. Crystal, Alejandro Torres, Damien LaPar, Paul Chai, Emile Bacha, David Kalfa.
Columbia University Medical Center, New York, NY, USA.
 45.
Degenerative Mitral Valve Disease: Does Minimally-Invasive Surgery Have An Impact On Early and Mid- Term Results?
Maria Ascaso Arbona1, Alvaro Barranco2, Elena Sandoval1, Eduard Quintana1, Clemente Barriuso1, Jose Luis Pomar1, Manel Castella1, Daniel Pereda1.
1Hospital Clinic Barcelona, Barcelona, Spain, 2Universitat de Barcelona, Barcelona, Spain.
 46.
 47.
Minimally Invasive Non-Resectional Mitral Valve Repair for Degenerative Mitral Regurgitation can be Performed with Excellent Outcomes and Durability
Andrea L. Axtell, Philicia Moonsamy, Jacob P. Dal-Bianco, Jonathan J. Passeri, Thoralf M. Sundt, III, Serguei Melnitchouk.
Massachusetts General Hospital, Boston, MA, USA.
 48.
Combined Aortic and Mitral Dystrophic Insufficiency: A Standardized Repair with Mitral and Aortic Ring Annuloplasty
Mazin A. Fatani1, Mustafa Zakkar2, Pouya Youssefi1, Alain Berrebi1, Jean Luc Monin1, Nizar Khelil1, Mathieu Debauchez1, Emmanuel Lansac1.
1Institute Mutualiste Montsouris, Paris, France, 2St George's Hospital, London, United Kingdom.
3:00 - 3:30
BREAK
PLENARY SESSION IV
3:30 - 5:30
Networked HVD Science Today and Tomorrow
Moderators: Emmanuel Lansac, MD, PhD, Jane Grande-Allen, PhD
Discussants: Murali Padala,PhD, Wei Sun, Bob Levine, Liesl Zuhlke, MD, Johanna Takkenberg MD, PhD, Mona Khalid, Angel Curria

Winners of Poster Competition Announcement
3:30 - 3:35
Introduction Talk: Importance of Valve Research Network
Jane Grande-Allen, PhD
3:35 - 3:50
Integrated Approach for Patient Specific Modeling
Murali Padala, PhD and Wei Sun, PhD
3:50 - 4:05
A Living Aortic Bioprosthesis: Dream or Reality?
Carlijn Bouten
4:05 - 4:20
Burning Unsolved HVD Issues
Liesl Zuhlke, MD
4:20 - 4:35
Optimizing HV patient outcome through networked science and standardized evaluation
Johanna Takkenberg, MD, PhD
4:35 - 4:50
Global Standards to Evaluate Patients Outcomes: Why Do We Need Them?
Mona Khalid - (TBD)
4:50 - 5:05
The Vision of the OECD Ministers of Health: What is the Paris Program and How is it Financed?
Angel Curria (OECD secretary-general or representative)
5:05 - 5:30
Round Table: The Road Towards Optimal Networked HVD Science and Patient Centered Care
SATURDAY, 13 APRIL 2019
7:00 - 8:00
VRN MEETINGS
7:00 - 8:00
BREAKFAST SYMPOSIA
AORTIC VALVE SESSION V
8:00 - 9:30
Hot Debates in the Treatment of Aortic Valve Disease
Moderators: Anna Sonia Petronio, MD, Johanna Takkenberg, MD PhD,
Discussants: Thomas Modine, MD, Megan Coylewright, MD, MPH, Joseph Bavaria, MD, Ismail El-Hamamsy, MD, PhD, Carlos Ruiz, MD, Julien Magne, PhD, Blase Carabello, MD
8:00 - 8:32
What is the Best Option to Replace a Non-Repairable Valve in Middle-Aged Patients?

I Favor a Bioprosthetic Valve (8 min)

Thomas Modine, MD

I Favor TAVI (8 min)
Carlos Ruiz, MD

I do a Ross (8 min)
Ismail El-Hamamsy, MD, PhD

I choose the best option together with the patient (8 min)
Megan Coylewright, MD, MPH
8:32 - 8:40
Discussion
8:40 - 8:56
There Should Be No Age Limit for TAVR vs SAVR

Yes (8 min)

Anna Sonia Petronio, MD

No (8 min)
Joseph Bavaria, MD
8:56 - 9:04
Discussion
9:04 - 9:20
Low-Gradient "Severe" AS with Preserved LVEF Should Undergo AVR

Yes (8 min)

Julien Magne, PhD

No (8 min)
Blase Carabello, MD
9:20 - 9:30
Discussion
MITRAL VALVE SESSION III
8:00 - 9:30
The Latest in Mitral Valve Interventions
Moderators: Alain Berrebi, MD Vinod Thourani, MD, Rakesh Suri, MD, DPhil
Discussants: Michael Sacks, PhD, Martin Swaans, MD, PhD, Samir Kapadia, MD, Jan Van Der Heyden, MD, Jean François Obadia, MD, PhD, Marc Gillinov, MD
8:00 - 8:10
In-Silico Patient-Specific Simulation for Optimal Treatment of FMR - What is Currently Possible?
Michael Sacks, PhD
8:10 - 8:20
Fusion Imaging to Support Mitral Interventions: The Essential Partner
Martin Swaans, MD, PhD
8:20 - 8:30
The Tale of Two Cities: The Mitra-FR and the COAPT Studies - A Critical Review
Samir Kapadia, MD
8:30 - 8:40
Outcomes After Transcatheter Annular Reduction Therapy in Mitral Regurgitation
Jan Van Der Heyden, MD
8:40 - 8:50
Interventional Approach for Implanting Artificial Chordae in MR
Jean François Obadia, MD, PhD
8:50 - 9:00
Mitral valve repair: 5 techniques for 95% success
Marc Gillinov, MD
9:00 - 9:30
Discussion
VALVE SCIENCE SESSION V
8:00 - 9:30
Valve Mechanobiology in Valvulogenesis, Disease Modeling and Clinical Therapies
Moderators: Murali Padala, PhD, Elaine Tseng, MD
Discussants: Sandra Loerakker, PhD, Choon Hwai Yap, PhD, Jesper Hjortnaes, MD, PhD, Alicja Sielicka, PhD,
8:00 - 8:18
Impact of Different Monocusp Valve Designs on Hemodynamics in the Pulmonary Artery: A Computational Investigation?
Sandra Loerakker, PhD
8:18 - 8:36
Biomechanics of Valvulogenesis Using 4D High Frequency Ultrasound and Computational Modelling
Choon Hwai Yap, PhD
8:36 - 8:54
In Vitro Models of Valve Disease to Study Mechanotransduction and Drug Targets
Jesper Hjortnaes, MD, PhD
8:54 - 9:12
Modulating Valve Tissue Mechanics and Material Properties After Surgical Repair Using Systemic Drugs in Swine
Alicja Sielicka, PhD
9:12 - 9:30
Pulmonary Autograft Biomechanics and Remodeling in Patients After the Ross Procedure
Ismail El-Hamamsy, MD, PhD
CONGENITAL HVD SESSION III
8:00 - 9:30
The Congenital Pulmonary and Tricuspid Valve Disease: Perspectives from Surgeons, Interventionalists, Scientists and Engineers
Moderators: David Kalfa, MD, PhD, Jolanda Kluin, MD, PhD
Discussants: Alejandro Torres, MD, Viktor Tsang, MD, Peter Zilla, Emre Belli, MD, Catherine Mercer, MD, PhD
8:00 - 8:15
Update regarding Transcatheter Pulmonary Valve Replacement for the Native Outflow Tract
Alejandro Torres, MD
8:15 - 8:35
Debate - Congenital Pulmonary Valve: To Spare or Not to Spare that is the Question...

Why I Amost Never Cut the Annulus

David Kalfa, MD, PhD

Why I Almost Always Cut the Annulus
Viktor Tsang, MD
8:35 - 8:45
Discussion (Led by Peter Hammer, PhD)
8:45 - 9:00
Current Challenges in HV Tissue Engineering
Peter Zilla, MD
9:00 - 9:15
Surgical Options for Ebstein Disease
Emre Belli, MD
9:15 - 9:30
Genetics of the Ebstein Disease
Catherine Mercer, MD, PhD
8:00 - 9:30
ABSTRACT SESSION: Surgical Valve All Topics
Moderator and Introduction to Session:
When to Spare/Repair and When to Replace the Valve in Patients with Aortic Root Aneurysm?

Gregory Fontana, MD
 49.
Outcomes of Concomitant Tricuspid Valve Surgery During Left Ventricular Assist Device Implantation: An Analysis Of The EUROMACS Registry
Kevin M. Veen1, Kadir Caliskan, MD, PhD1, Theo M.M.H. de By, MBA2, Mostafa M. Mokhles, MD, PhD1, Osama I. Soliman, MD, PhD1, Paul Mohacsi, MD, eMBA3, Felix Schoenrath, MD, PhD4, Jan Gummert, MD, PhD5, Lech Paluszkiewicz, MD, PhD5, Ivan Netuka, MD, PhD6, Mustafa Ozbaran, MD7, Johanna J.M. Takkenberg, MD, PhD1, Ad J.J.C. Bogers, MD, PhD1, EUROMACS investigators2.
1Erasmus MC, Rotterdam, Netherlands, 2EUROMACS Registry, Windsor, United Kingdom, 3University Hospital Zurich, Zurich, Switzerland, 4German Heart Center Berlin, Berlin, Germany, 5Heart and Diabetes Centre NRW, Bad Oeynhausen, Germany, 6Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 7Ege University, Izmir, Turkey.
 50.
Long-term Outcomes After Bicuspid Aortic Valve Repair With An External Aortic Ring Annuloplasty
Mustafa Zakkar, Vito D. Bruno, Sarah Pousset, Isabelle Di Cante, Jean Luc Monnin, Nizar Khelil, Mathieu Debauchez, Emmanuel Lansac.
Institut Mutualiste Montsouris, PARIS, France.
 51.
Patient-prosthesis Mismatch in Elderly Women: The Beneficial Impact of Sutureless Valves Versus Stented Bioprostheses
Giacomo Bianchi, MD, PhD, Anna Laganà, MD, Rafik Margaryan, MD, PhD, Marco Solinas.
Ospedale del Cuore - Fondazione Toscana, Massa, Italy.
 52.
Re-Repair of the Bicuspid Aortic Valve
Ulrich Schneider, MD, Tristan Ehrlich, MD, Irem Karliova, MD, Christian Giebels, MD, Hans-Joachim Schäfers, MD.
Saarland University Medical Center, Homburg, Germany.
 53.
Decellularized Allografts for RVOT Reconstruction in Children - 12 Years Results of A Multi-institutional Experience
Francisco D. Costa1, Marcelo Jatene2, Leonardo Mianna2, Fernando Moraes3, Gabriela M. Schorn1, Myriam Wisniewski1, Leonardo Mulinari4.
1Hospital Infantil Pequeno Príncipe, Curitiba, Brazil, 2INCOR - SP, São Paulo, Brazil, 3Hospital Real Portugues, Recife, Brazil, 4Santa Casa de Curitiba PUCPR, Curitiba, Brazil.
 54.
Assessment of Stroke Volume Index of Sutureless, Transcatheter and Stented Pericardial Valves in the Early Postoperative Period - A Propensity Matched Analysis
Alessia Gambaro, Michael O. Murphy, Davorin Sef, Alison Duncan, John Pepper, Cesare Quarto, Ulrich Rosendahl, George Asimakopoulos.
Royal Brompton and Harefield NHS Trust, London, United Kingdom.
 55.
Long-term Outcomes of Small-size Heart Valve Bioprostheses: Comparative Study between Mitroflow and Magna Pericardial Xenografts
ZAID ALHAMWY, A. Baluja, S. Souaf, B. Adrio, J. Sierra, D. Duran, J. Garcia, AL. Fernandez Gonzalez.
University of Santiago de Compostela, Santiago de Compostela, Spain.
 56.
Aortic Valve Sparing Root Replacement in Tricuspid Valve Diseases
Saadallah TAMER, Stefano Mastrobuoni, Mona Momeni, David Vancraeynest, Jean Rubay, Gebrine Elkhoury, Philippe Noirhomme, Laurent De Kerchove.
Cliniques Universitaires St-Luc, Woluwe-Saint-Lambert, Belgium.
9:30 - 10:00
BREAK
10:00 - 12:00
CHALLENGING CASES
10:00 - 10:07
When to Address the Mitral Valve when Treating HOCM
Gilles Dreyfus, MD
10:07 - 10:12
Discussion
10:12 - 10:19
What is the Optimal Timing for Degenerative Mitral valve Intervention
Maurice Sarano, MD
10:19 - 10:24
Discussion
10:24 - 10:31
Is Index Left Ventricular Volume a Better Predictor for Timing of Mitral Valve Repair
Julia Grapsa, MD
10:31 - 10:36
Discussion
10:36 - 10:43
The Ideal Case for use of Transcatheter Mitral Valve Replacement
Milind Desai, MD
10:43 - 10:48
Discussion
10:48 - 10:55
Can a Percutaneous Leaflet and Annular Approach Duplicate Surgical Mitral Valve Repair?
Rakesh Suri, MD, DPhil
10:55 - 11:00
Discussion
11:00 - 11:07
How I Perform Robotic Mitral Valve Repair Most Frequently
Gurjyot Bajwa, MD
11:07 - 11:12
Discussion
11:12 - 11:19
Management of the Left Atrial Appendage at the Time of Mitral Valve Repair
Marc Gillinov, MD
11:19 - 11:24
Discussion
11:24 - 11:31
What I think the Most Durable Solution to Functional Tricuspid Regurgitation Should Look Like
Joanna Chikwe, MD
11:31 - 1136
Discussion
11:36 - 11:43
Oops I Placed a Percutaneous Mitral Anchor in the Coronary Artery, Now What?
Mahmoud Traina, MD
11:43 - 11:48
Discussion
11:48 - 11:55
Early Failure of Transcatheter Aortic Valve - This is How I Detect and Access
Wael Jaber, MD
11:55 - 12:00
Discussion
10:00 - 11:30
ABSTRACT SESSION: Valve Science & Tissue Engineering
Moderator and Introduction to Session:
Monocytes and Macrophages in Heart Valves: Uninvited Guests or Critical Performers?

Jonathan Butcher, PhD & Terence Gee
 57.
Long-term Evaluation of a Novel Tissue-engineered Heart Valve without any Foreign Bodies
Yoshiaki Takewa1, Yasuhide Nakayama2, Junichi Shimamura1, Nobumasa Katagiri1, Eisuke Tatsumi1.
1National Cerebral and Cardiovascular Center, Osaka, Japan, 2Biotube Inc., Tokyo, Japan.
 58.
One year Results of Aortic Valve Reconstruction Using an in body Tissue Architecture Goat Model
Keitaro Okamoto1, Takayuki Kawashima1, Kyouhei Hatori1, Tomoyuki Wada1, Takeshi Terazawa2, Tadashi Umeno1, Takashi Shuto1, Hirofumi Anai1, Yasuhide Nakayama2, Shinji Miyamoto1.
1Oita University, Oita, Japan, 2Biotube Co., Ltd., Tokyo, Japan.
 59.
Expandable Polyurethane Stent Valve, Implanted by Catheter
Miguel A. Maluf1, Mariana G. Massei2.
1Universidade Federal de São Paulo, São Paulo, Brazil, 2Universidade Federal de São Paulo, São paulo, Brazil.
 60.
Engineered Tissue Transcatheter Valve for Pulmonary and Tricuspid Valve Implant
Zeeshan Syedain.
University of Minnesota, Minneapolis, MN, USA.
 61.
Thrombocytopenia After Surgical And Transcatheter Aortic Valve Replacement: Are There Any Differences?
Ferdinand Vogt1, Marco Moscarelli2, Francesco Pollari3, Dennis Eckner4, Christian Langhammer5, Steffen Pfeiffer3, Thomas Bertsch5, Matthias Pauschinger4, Theodor Fischlein3, Giuseppe Santarpino3.
1Paracelsus Medical University Nuremberg, Nuremberg, Germany, 2Anthea Hospital, GVM Care & Research, Bari, Cardiac Surgery, Italy, 3Paracelsus Medical University Nuremberg, Cardiac Surgery, Germany, 4Paracelsus Medical University Nuremberg, Cardiology, Germany, 5Paracelsus Medical University Nuremberg, Institute for Laboratory Medicine, Germany.
 62.
Interstitial Cells from Calcified and Healthy Aortic Valves Have Different Phenotype and Functions
Mariia Bogdanova1, Arsenii Zabirnyk1, Anna Malashicheva2, Katarina Zihlavnikova Enayati1, Kåre-Olav Stensløkken1, Arkady Rutkovskiy3, Jarle Vaage3.
1Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway, 2Almazov National Medical Research Centre, Saint-Petersburg, Russian Federation, 3Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
 63.
A Model to Study Endothelial-Mediated Valve Disease and Repair Potential of VECs
Emily Nordquist, Michael Mcdermott, Joy Lincoln.
Nationwide Children's Hospital, Columbus, OH, USA.
 64.
Unveiling the Genomic Organization at GWAS Loci at Risk for Non-Syndromic Mitral Valve Prolapse
Sergiy Kyryachenko1, Mengyao Yu1, Adrien Georges1, Russell Norris2, Nabila Bouatia-Naji1.
1INSERM UMR970, Paris Cardiovascular Research Center, Paris, France, 2Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA.


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