The Heart Valve Society
2018 Program

Final Program   Moderated Posters   Display Posters

Thursday, April 12th
7:50 - 8:00
Welcome and Opening of the 4th Scientific Meeting of the Heart Valve Society
Martin B. Leon, MD, President of the Heart Valve Society
8.00 - 10:00
Presidential Plenary Session I: A Futuristic Vision of Valvular Heart Disease
Moderators: Martin B. Leon, MD, Hanneke Takkenberg, MD, PhD,
Discussants: Vinod Thourani, MD, Gilles Dreyfus, MD, Maurice Sarano, MD, Rakesh Suri, MD, PhD, Michael Borger, MD, Eberhard Grube, MD
8:00 - 8:30
Presidential Address: The Emergence of Structural Heart Disease and the Multidisciplinary Heart Team
Martin B. Leon, MD
8:30 - 9:00
Live Case Demonstration from the Montreal Heart Institute
9:00 - 9:15
Featured Lecture: One Valve for Life - Tissue Engineered Heart Valves on the Verge of Clinical Application!
Peter Zilla, MD
9:15 - 9:20
9:20 - 9:35
Featured Lecture: Redefining Aortic Stenosis – Can Quantitative Metrics Replace Symptom-Directed Intervention for Aortic Stenosis
Elazer Edelman, MD PhD
9:35 - 9:40
9:40 - 9:55
Featured Lecture: The Current and Future Impact of TAVI on Cardiovascular Medicine - My Crystal Ball for the Next Decade
Eberhard Grube, MD
9:55 - 10:00
10:00 - 10:30
Coffee Break
10:30 - 12:00
Commemorative Plenary Session - Celebrating the 50th Anniversary of the Circulation Aortic Stenosis Natural History Manuscript
Moderators: Martin B. Leon, MD and Robert O. Bonow, MD
Discussants: Gregg W. Stone, MD, Tirone David, MD, Alain Cribier, MD, Elazer Edelman, MD, PhD, Eugene Braunwald, MD, Michael Mack, MD
10:30 - 10:45
Personal Reflections on the Natural History of Aortic Stenosis
Eugene Braunwald, MD
10:45 - 11:00
Roundtable Discussion
11:00 - 11:15
Aortic Stenosis Today: 50 Years of Evolutionary Thinking and Current Knowledge Gaps
Robert O. Bonow, MD
11:15 - 11:20
11:20 - 11:35
Perspectives on Changing Surgical Therapies for Aortic Stenosis
Tirone David, MD
11:35 - 11:40
11:40 - 11:55
The Journey to Create Transcatheter Therapy Alternatives for Aortic Stenosis Patients
Alain Cribier, MD
11:55 - 12:00
11:45 - 11:57
Can Quantitative Metrics Replace Symtom-Directed Intervention For Aortic Stenosis
Elazer Edelman, MD, PhD
11:57 - 12:00
12:00 - 1:00
LUNCHEON SYMPOSIUM: Transcatheter Mitral Valve Replacement: Preparing for the next revolution
Moderators: David Adams, MD and Patrick McCarthy, MD
12:00 - 12:03
Session objectives
David Adams, MD
12:03 - 12:13
Transcatheter mitral valve replacement: Rationale and Opportunity
Maurice Sarano, MD
12:13 - 12:18
12:18 - 12:28
Screening and selecting the appropriate TMVR patient
Hasan Jilaihawi, MD
12:28 - 12:33
12:33 - 12:43
Transcatheter Mitral Valve Replacement Global Pilot Study Outcomes: Lessons Learned
Vinayak Bapat, MD
12:43 - 12:48
12:48 - 1:00
Session evaluation and key learnings
Patrick McCarthy, MD
12:00 - 1:30
12:00 - 1:30
Valve Science Abstracts: Innovation and Translation in Tissue Engineering
Moderators: Kristyn Masters, MD, Jonathan Butcher, PhD
Discussants: Ari Pieter Kappetein, MD, PhD, David Kalfa, MD, PhD, Jordan Miller, PhD
Design of a Novel Multidirectional Fluid Shear Stress Bioreactor to Replicate Bicuspid Aortic Valve Aorta Hemodynamics In Vitro
Janet Liu, Kurtis Cornelius, Mathew Graham, Tremayne Leonard, Austin Tipton, Abram Yorde, Philippe Sucosky.
Wright State University, Dayton, OH, USA.
In Situ Cardiovascular Tissue Engineering using Degradable Polymeric Scaffolds: Scaffold Optimization and Long-term In-vivo Follow-up
Jolanda Kluin1, Anthal Smits2, Hanna Talacua1, Emanuela Fioretta3, Max Emmert3, Serge Söntjens4, Henk Janssen4, Simon Hoerstrup3, Patricia Dankers2, Frank Baaijens2, Carlijn Bouten2.
1Academic Medical Center, Amsterdam, Netherlands, 2Eindhoven University of Technology, Eindhoven, Netherlands, 3University of Zürich, Zürich, Switzerland, 4SyMO-CHEM, Eindhoven, Netherlands.
First Implantation of a Hybrid Tissue-Engineered Heart Valve in a Sheep's Mitral Position
Ramin Zareian1, Daisuke Morisawa1, Roger S. Geertsema1, Earl Steward1, Mariwan Majid1, Arti Kapadia1, Clinton Wynne2, Jeffrey C. Milliken1, Arash Kheradvar1.
1University of California, Irvine, Irvine, CA, USA, 2GE Healthcare, San Diego, CA, USA.

Invited Speaker – Novel strategies to slow progression of aortic valve stenosis
Jordan Miller, MD
12 minutes talk with 5 minute discussion
Tissue-engineered Pediatric Pulmonary Valve Conduit in Growing Lamb Model
Zeeshan Syedain, Mathew Lahti, Richard Bianco, Robert Tranquillo.
University of Minnesota, Minneapolis, MN, USA.
Right Ventricular Outflow Tract Regeneration: Last Development of the TEH-Tube Project
David Kalfa1, Paul Hommes-Schattmann2, Bilal Ahmad3, Margaux Pontailler4, Axel Neffe2, Marilys Blanchy5, Gareth Williams6, Philippe Menasché7, Andreas Lendlein8, Pierre Pouponneau9.
1TEH-Tube scientific coordinator, Columbia University, NYC, NY, USA, 2Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, berlin, Germany, 3UCL School of Pharmacy, Department of Electrospinning, University College London, London, United Kingdom, 4INSERM U 970, PARCC & Laboratory of Biosurgical Research, Paris, France, 5Rescoll, Bordeaux, France, 6UCL School of Pharmacy, Department of Electrospinning, University College London, london, United Kingdom, 7Department of Cardiovascular Surgery, Hôpital Européen Georges Pompidou; University Paris Descartes, Sorbonne Paris Cité, Paris, France, 8Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Berlin, Germany, 9Statice SAS, Besacon, France.
The SULEEI Procedure - A Novel Approach For Crosslinking And Sterilization Of Pericardia For Manufacturing Bioprosthetic Heart Valves
Simona Walker1, Jessy Schönfelder1, Aline Jakob2, Christiane Wetzel1, Sems-Malte Tugtekin2, Michael C Hacker3, Michaela Schulz-Siegmund3.
1Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, Dresden, Germany, 2Department of Cardiac Surgery, Faculty of Medicine CGC, Technische Universität Dresden, Herzzentrum Dresden, Dresden, Germany, 3Institute of Pharmacy, Pharmaceutical Technology, Leipzig University, Leipzig, Germany.
1:30 - 3:00
5 Concurrent Sessions
Aortic Valve Disease Track
Mitral Tricuspid Track
Valve Science Track
Special Topics Track
Abstract Session - Aortic Valve

1:30 - 3:00
Calcific Aortic Valve Disease: Clinical and Basic Research Highlights
Moderators: Magnus Back, MD and Elazer Edelman, MD, PhD
Discussants: Calvin Yeang, MD, PhD, Isaac George, MD, Jeffrey Borer, MD, Philippe Genereux, MD, Marie-Annick Clavel, DVM, PhD, Torsten P. Vahl, MD,PhD
1:30 - 1:42
Calcific Aortic Stenosis Occurrence and Progression - A Clinical Perspective
Magnus Back, MD
1:42 - 1:45
1:45 - 1:57
The Role of Lp(a) in Calcific Aortic Valve Disease: Clinical and Basic Research Evidence
Calvin Yeang, MD
1:57 - 2:00
2:00 - 2:12
Developmental Pathways in Calcific Aortic Valve Disease
Bin Zhou, MD
2:12 - 2:15
2:15 - 2:27
New Experimental Models to Study Calcific Aortic Valve Disease
Jesper Hjortnaes, MD, PhD
2:27 - 2:30
2:30 - 2:42
The Role of Biomarkers in Aortic Valve Disease
Marie-Annick Clavel, DVM, PhD
2:42 - 2:45
2:45 - 2:57
New TAVR Systems for Calcific Aortic Stenosis
Torsten P. Vahl, MD, PhD

1:30 - 3:00
Mitral Regurgitation - Anatomy, Pathophysiology, Imaging and Medical Therapy
Moderators: Mark Reisman, MD, Gregg W. Stone, MD
Discussants: Giovanni Ferrari, PhD, Jonathan Weinsaft, MD, Rakesh Suri, MD, Francesco Grigioni, MD, Stephanie Mick, MD, Gilbert Tang, MD
1:30 - 1:42
Anatomy of the Mitral Valve Apparatus
Mark Reisman, MD
1:42 - 1:45
1:45 - 1:57
Understanding the Mechanisms Contributing to Degenerative and Functional MR
Giovanni Ferrari, PhD
1:57 - 2:00
2:00 - 2:12
Quantitative Imaging of the Mitral Valve
Maurice Sarano, MD
2:12 - 2:15
2:15 - 2:27
Pathophysiology and Natural History of Degenerative MR
Francesco Grigioni, MD
2:27 - 2:30
2:30 - 2:42
Pathophysiology and Natural History of Functional MR
Jonathan Weinsaft, MD
2:42 - 2:45
2:45 - 2:57
Guideline-Directed Medical Therapy for MR: When is Intervention Needed? Insights from COAPT?
Gregg Stone, MD
2:57 - 3:00

1:30 - 3:00
Innovations in Aortic Stenosis
Moderators: Adrian Chester, PhD and Joy Lincoln, MD
Discussants: Simon C. Body, MD, Kristyn Masters, MD, Francesco Pasqualini, MD, Jane Grande-Allen, PhD Jonathan Butcher, PhD and Wei Sun, PhD.
1:30 - 1:42
Genetic Mechanisms of Bicuspid Aortic Valve-Related Aortopathy
Simon C. Body, MD
1:42 - 1:45
1:45 - 1:57
Engineered Models to Study Inflammation in Aortic Stenosis
Kristyn Masters, MD
1:57 - 2:00
2:00 - 2:12
Therapeutic Discoveries in the Treatment of Calcific Aortic Valve Disease
Joy Lincoln, MD
2:12 - 2:15
2:15 - 2:27
Nano Fabrication of Aortic Valve Disease Models
Francesco Pasqualini, MD
2:27 - 2:30
2:30 - 2:42
Is there an Appropriate In Vitro Model of Aortic Valve Calcification?
Jonathan Butcher, PhD
2:42 - 2:45
2:45 - 2:57
CTA-Based Biomechanical Simulations to Predict and Explain TAVR Complications
Wei Sun, PhD
2:57 - 3:00

1:30 - 3:00
Controversies in Valvular Heart Disease I
Moderators: Gilles Dreyfus, MD and David Adams, MD
Discussants: Philippe Pibarot, DVM, PhD, Judy Hung, MD, Rakesh Suri, MD, Craig R. Smith, MD, Eberhard Grube, MD, Howard Herrmann, MD

1:30 - 1:42
FLASH DEBATE: Management of Patients with Low Gradient, Normal EF Aortic Stenosis

All Should Be Treated!
Philippe Pibarot, DVM, PhD

A Selective Approach is Warranted
Judy Hung, MD
1:42 - 1:48
1:48 - 2:00
FLASH DEBATE: Patients Undergoing SAVR Should Receive a Bioprosthesis

ALL Patients!
Patrick McCarthy, MD

Selective Patients
Michael Borger, MD
2:00 - 2:06
2:06 - 2:18
FLASH DEBATE: Should Severe Functional MR be Defined Differently for Ischemic Patients?

Of Course!
Rebecca Hahn, MD

No Way...
Maurice Sarano, MD
2:18 - 2:24
2:24 - 2:36
FLASH DEBATE: Conventional Surgery for Degenerative MR Will Be Replaced by Transcatheter Techniques in 20 Years

Without a Doubt!
Andrea Colli, MD

Not a Chance!
David Adams, MD
2:36 - 2:42
2:42 - 2:54
FLASH DEBATE: The MitraClip FMR Trials Will Affect Current Practice...

My Prediction: They will be POSITIVE and MitraClip will Reign Supreme!!
Maurizio Taramasso, MD

My Prediction: They will be NEGATIVE and MitraClip will Remain a Niche Technology!
Giles Dreyfus, MD
2:54 - 3:00

1:30 - 3:00
Aortic Valve
Moderators: Tom Nguyen, MD and Ezequiel Molina, MD
Discussants: Philippe Pibarot, DVM, PhD, Susheel Kodali, MD and Ori Ben-Yehuda, MD
Medtronic Freestyle in 971 patients over a 18 year time period: the Oldenburg Experience
Jerry Easo1, Alexander Weymann1, Marcin Szczechowicz1, Philipp Hölzl2, Ahmed Mashhour1, Konstantin Zhigalov1, Michael Horst1, Harald Eichstaedt1, Juergen Ennker1, Otto Dapunt3.
1University Hospital Oldenburg, Oldenburg, Germany, 2Helios Hospital Siegburg, Siegburg, Germany, 3Medical University of Graz, Graz, Austria.
Outcomes of Patients with Significant Obesity Undergoing TAVR or SAVR in the Randomized PARTNER 2 Trial
Shmuel Chen1, Bjorn Redfors1, Ori Ben-Yehuda1, Aaron Crowley1, Danny Dvir2, John Webb3, Sung-Han Yoon4, Raj Makkar4, Vinod Thourani5, Murat Tuzcu6, Michael Mack7, Tamim Nazif8, Isaac George8, Susheel Kodali8, Martin Leon8.
1Cardiovascular Research Foundation, New York, NY, USA, 2University of Washington, Seattle, WA, USA, 3St. Paul's Hospital, Vancouver, BC, Canada, 4Cedars-Sinai Medical Center, Los Angeles, CA, USA, 5Medstar Washington Hospital Center, Washington, DC, USA, 6Cleveland Clinic, Cleveland, OH, USA, 7Baylor Scott & White Health, Plano, TX, USA, 8Columbia University Medical Center, New York, NY, USA.
Development of a Novel Deep Learning System for Aortic Valve Flow Quantification on Cardiac Magnetic Resonance Imaging.
Alex Bratt, M.D.1, Meredith Pollie, B.S.2, Noel Codella, Ph.D.3, Wayne Colizza, M.D.1, Rocio Perez-Johnston, M.D.4, Jiwon Kim, M.D.2, Jonathan Weinsaft, M.D.2.
1Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY, USA, 2Weill Cornell Medicine, New York, NY, USA, 3IBM TJ Watson Research Center, Yorktown Heights, NY, USA, 4Memorial Sloan Kettering Cancer Center, New York, NY, USA.
15 Years Outcomes Following Bioprosthetic Versus Mechanical Aortic Valve Replacement In Patients Aged 50 To 65 Years With Isolated Aortic Stenosis
Emiliano A. Rodríguez-Caulo, Juan Otero-Forero, María-José Mataró, Gemma Sánchez-Espin, Arantza Guzón, Carlos Porras, José M. Villaescusa, Miguel Such, José-María Melero-Tejedor.
Hospital Universitario Virgen de la Victoria de Málaga, Málaga, Spain.
Invited Speaker -
Choice of TAVR Valve Types: Choices based on anatomical considerations
Susheel Kodali, MD
12 minutes talk with 5 minute discussion
Bioprosthetic Valve Fracture to Facilitate ViV TAVR in Small Surgical Bioprostheses
Keith Allen1, Adnan Chhatriwalla1, John Saxon1, David J. Cohen1, Vinod Thourani2, Josh Rovin3, Anthony Bavry4, Tom C. Nguyen5, Richard Lee6, Brian Whisenant7, Mark J. Russo8.
1St. Luke's Mid America Heart Institute, Kansas City, MO, USA, 2Emory University School of Medicine, Atlanta, GA, USA, 3Morton Plant Hospital, Tampa Bay, FL, USA, 4University of Florida, Gainesville, FL, USA, 5University of Texas Medical School at Houston, Houston, TX, USA, 6Saint Louis University, St. Louis, MO, USA, 7Intermountain Heart Institute, Murry, UT, USA, 8Newark Beth Israel Medical Center, Newark, NJ, USA.
Multi-Biomarker Approach as Prognostic Tool In Patients With Severe Aortic Stenosis Undergoing Surgical Valve Replacement
Ricardo A. Spampinato, Rafal Bochen, Franz Sieg, Konstantin von Aspern, Josephina Haunschild, Elfriede Strotdrees, Sven Lehmann, Christian Etz, Michael A. Borger.
Heart center Leipzig, Leipzig, Germany.
Estimation of Stroke Volume and Aortic Valve Area in Patients with Aortic Stenosis: A Comparison of Doppler-Echocardiography and Cardiac Magnetic Resonance
Ezequiel Guzzetti, Philippe Pibarot, DVM, PhD, Marie-Annick Clavel, Lionel Tastet, MSc, Mohamed-Salah Annabi, Eric Larose, Romain Capoulade, PhD, Julio Garcia, PhD, Marie Arsenault, Elisabeth Bedard.
IUCPQ, Quebec, QC, Canada.
3:00 - 3:30
Coffee Break
3:30 - 5:30
Plenary Session II: A Global Perspective on Inclusive Heart Valve Disease Care
Moderators: Hanneke Takkenberg, MD, PhD, Cheryl Pegus, MD,
Discussants: Jose Pomar, MD, PhD, Liesl Zuhlke, MD, Megan Coylewright, MD, Ori Ben-Yehuda, MD, Jane Grande-Allen, PhD, Howard Hermann, MD
3:30 - 4:00
Live Case Demonstration from the Montreal Heart Institute
4:00 - 4:10
Why "Inclusive" Heart Valve Disease Care is Critical for the Future? My Perspectives...
Hanneke Takkenberg, MD, PhD
4:10 - 4:25
Featured Lecture: Global Safe Surgery
Jose Pomar, MD, PhD
4:25 - 4:30
4:30 - 4:45
Featured Lecture: Putting Race, Ethnicity and Gender on the Cardiovascular Care Agenda
Sheryl Pegus, MD
4:45 - 4:50
4:50 - 5:05
Featured Lecture: The REMEDY for Rheumatic Heart Disease
Liesl Zuhlke, MD
5:05 - 5:10
5:10 - 5:25
Featured Lecture: Including the Patient in HVD Treatment Decision Making
Megan Coylewright, MD
5:25 - 5:30
5:30 - 5:45
HVS Business Meeting
5:30 - 7:00
Poster Competition and Reception
Lead Moderator: Marta Sitges, MD

Group 1: Innovations in Experimental Valve Science
Moderator: Christine Kern

Group 2: Tissue Engineering for Regenerative Medicine and Modeling Disease
Moderator: Philippe Sucosky

Group 3: Cardiac Imaging
Moderator: Marie Anne Clavel

Group 4: Surgical Valve Therapies I
Moderator: Mostafa Mokhles, MD

Group 5: Surgical Valve Therapies II
Moderator: Maurizio Tamarasso

Group 6: Transcatheter Therapies
Moderator: Laura Sanchis
Friday, April 13th
7.00 - 8.00
VRN Meetings
8:00 - 10:00
Plenary Session III: Next Frontier - Advances in the Care of Asymptomatic Mitral and Tricuspid Valve Disease
Moderators: Rakesh Suri, MD and Maurice Sarano, MD
Discussants: Milind Desai, MD, Brian Griffin, MD, Rebecca Hahn, MD, Wael Jaber, MD, Didier Loulmet, MD and Paul Sorajja, MD, Stephanie Mick, MD, Michael Borger, MD
8:00 - 8:30
Live Case Demonstration from the Cleveland Clinic
8:30 - 8:45
Featured Lecture: Advancing Indications in Degenerative MR Correction
Maurice Sarano, MD
8:45 - 8:50
8:50 - 9:05
Featured Lecture: Concurrent Functional TR - When is Enough Enough?
Yan Topilsky, MD
9:05 - 9:10
9:10 - 9:22
Why Don't All Cardiologists Quantify Degenerative MR?
Milind Desai, MD
9:22 - 9:26

Controversy: How I Want My Degenerative Mitral + Tricuspid Repair Done
9:26 - 9:34
Standard Surgery
Joanna Chikwe, MD
9:34 - 9:42
Didier Loulmet, MD
9:42 - 9:50
Total Percutaneous Transcatheter
Paul Sorajja, MD
9:50 - 10:00
Panel Discussion
10:00 - 10:30
Coffee Break
10:30 - 12:00

5 Concurrent Sessions
Aortic Valve Disease Track
Mitral Tricuspid Track
Valve Science Track
Special Topics Track
Abstract Session - Aortic Valve

10:30 - 11:30
Bioprosthetic Valve Degeneration– Empire State II-IV
Moderators: AArie Pieter Kappetein, MD, PhD, and Jordan Miller, MD
Discussants: Danny Dvir, MD, D. Craig Miller, MD, Wei Sun, PhD, Vinayak Bapat, MD, Hendrik Treede, MD, John Puskas, MD
10:30 – 10:45
Invited Lecture: Can We Accommodate the Growing Need of Untreated Aortic Stenosis: TAVR for the Underprivileged
Peter Zilla, MD
10:45 – 10:55
What Do We Know about the Mechanisms of Prosthetic Valve Degeneration?
Gino Gerosa, MD
10:55 – 11:05
Is Valve Durability Expected to be Similar for TAVR and SAVR Bioprostheses?
Arie Pieter Kappetein, MD, PhD
11:05 – 11:15
Advanced Tissue Preservation Technologies; Can We Expect Greater Durability?
John Puskas, MD
11:15 – 11:25
What Factors Affect Valve Durability: An Engineer’s Perspective on Design and Leaflet Optimization
Wei Sun, MD
11:25 – 11:30
11:30 - 12:15
Bicuspid Aortic Valve Disease – Empire State II-IV
Moderators: Patrick Mathieu, MD and Raj Makkar, MD
Discussants: Mathew Williams, MD, Hasan Jilaihawi, MD, Simon C. Body, MD, Jonathon Leipsic, MD, Vinod Thourani, MD, Eberhard Grube, MD
11:30 – 11:38
Understanding the Structure/Function Pathways and Natural History of Bicuspid Aortic Valve Disease
Patrick Mathieu, MD
11:38 – 11:46
Genetics and Genomics of Bicuspid Aortic Valve Disease
Simon C. Body, MD
11:46 – 11:54
Biomechanics of Bicuspid Aortic Valve Disease
Philippe Sucosky, PhD
11:54 – 12:00

FLASH DEBATE: SAVR vs. TAVR for Bicuspid Aortic Valve Disease
12:00 – 12:05
SAVR Should Remain the First Choice for BAV!
D. Craig Miller, MD
12:05 – 12:10
TAVR is Becoming the Preferred Option for BAV
Raj Makkar, MD
12:10 – 12:15

10:30 - 12:00PM
Tricuspid Regurgitation - Anatomy, Pathophysiology, Imaging and Medical Therapy
Moderators: Rebecca Hahn, MD and Yan Topilsky, MD
Discussants: Peter Fail, MD, Muhamed Saric, MD, PhD, Maurizio Taramasso, MD, Paolo Denti, MD, and Ori Ben-Yehuda, MD
10:30 - 10:42
Anatomy of the Tricuspid Valve Apparatus
Maurizio Taramasso, MD
10:42 - 10:45
10:45 - 10:57
Understanding the Mechanisms Contributing to Degenerative and Functional TR
Yan Topilsky, MD
10:57 - 11:00
11:00 - 11:12
Quantitative Imaging of the Tricuspid Valve
Rebecca Hahn, MD
11:12 - 11:15
11:15 - 11:27
Pathophysiology and Natural History of Degenerative TR
Muhamed Saric, MD, PhD
11:27 - 11:30
11:30 - 11:42
Pathophysiology and Natural History of Functional TR
Paolo Denti, MD
11:42 - 11:45
11:45 - 11:57
Medical Treatment of Tricuspid Regurgitation: Limitations of the Current Guidelines
Ori Ben-Yehuda, MD
11:57 - 12:00

10:30 - 12:00
Mitral Valve Disease: New Frontiers
Moderators: Murali Padala, PhD and Christine Kern, PhD
Discussants: Tommaso Mansi, PhD, Jane Grande-Allen, PhD, Peggi Angel, PhD, Russel Norris, PhD
10:30 - 10:42
What can MALDI (matrix-assisted laser desorption ionization imaging mass spectrometry) teach us about Mitral Valve Disease?
Peggi Angel, PhD
10:42 - 10:45
10:45 - 10:57
Malformation of Cilia and their Role in Mitral Valvulogenesis
Russell Norris, PhD
10:57 - 11:00
11:00 - 11:12
The Role of Serotonin and Catecholamines in the Pathology of Degenerative Mitral Valve Disease
Giovanni Ferrari, PhD
11:12 - 11:15
11:15 - 11:27
Wound Healing and Tissue Remodeling in Response to Mechanical Factors in the Mitral Valve
Jane Grande-Allen, PhD
11:27 - 11:30
11:30 - 11:42
3D - Ultrasound Guided Machine Learning Based Valve Geometries for Computational Modeling
Tommaso Mansi, PhD
11:42 - 11:45
11:45 - 11:57
'In-Air' Holographic Imaging of the Mitral Valve: Understanding Patho-biologic and Functional Anatomy for Transcatheter Procedures
Aviad Kaufman, MBA
11:57 - 12:00

10:30 - 12:00
Complications of Surgical Valve Prostheses
Moderators: Michael Borger, MD, Allan Schwartz, MD,
Discussants: Paul Sorajja, MD, Emmanuel Lansac, MD, Raj Makkar, MD, Michael Mack, MD, David Holzhey, MD
10:30 - 10:42
When Is Conservative Treatment of Prosthetic Valve Endocarditis Appropriate?
Allan Schwartz, MD
10:42 - 10:54
Surgical Prosthesis Leaflet Thrombosis: Incidence and Clinical Implications
Raj Makkar, MD
10:54 - 11:06
Transcatheter Valve-in-Valve Procedures: The New Gold Standard for ALL Patients?
Michael Mack, MD
11:06 - 11:18
Surgical Redo Valve Replacement: Do We Overestimate the Risk?
Michael Borger, MD
11:18 - 11:30
Prosthetic Valve Endocarditis: Optimal Surgical Treatment
Hiroo Takayama, MD
11:30 - 11:40
Diagnosis and Management of Post-TAVR Endocarditis
David Holzhey, MD
11:40 - 11:50
How Should We Define Structural Valve Deterioration in the Current Era?
Arie Pieter Kappetein, MD, PhD
11:50 - 12:00

10:30 - 12:00
Mitral Valve
Moderators: Vinod H. Thourani, MD, Mayra Guerrero, MD
Discussants: Judy Hung, MD, Mark Reisman, MD, Gino Gerosa, MD
Combined Mitral And Tricuspid Versus Isolated Mitral Valve Edge-to-edge Repair In Patients With Symptomatic Valve Regurgitation And High Surgical Risk
Thilo Noack1, Christian Besler2, Stephan Blazek2, Karl-Philipp Rommel2, Maximillian von Roeder2, Christian Luecke3, Karl Fengler2, Joerg Seeburger1, Joerg Ender4, Matthias Gutberlet3, Axel Linke2, Michael Andrew Borger1, Holger Thiele2, Philipp Lurz2.
1University Hospital for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany, 2University Hospital for Internal Medicine/Cardiology, Heart Center Leipzig, Leipzig, Germany, 3Department for Radiology, Heart Center Leipzig, Leipzig, Germany, 4Department for Anesthesiology, Heart Center Leipzig, Leipzig, Germany.
The Dynamics Of Coaptation Surface After Correction Mitral Valve Prolapse By Using Pre-measured Gore-tex Loops
Ivan Skopin, Irma Tsiskaridze, Grigory Danilov.
Bakoulev Scientific Center for Cardiovascular Surgery, Moscow, Russian Federation.
Repair or Replace? Answering a Surgical Dilemma with an Automated Image Analysis Tool
Ahmed H. Aly1, Frank Meijerink2, Thomas J. Eperjesi3, Wobbe Bouma4, Joseph H. Gorman, III5, Paul A. Yushkevich6, Robert C. Gorman5, Alison M. Pouch6.
1Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, 2University of Groningen, Groningen, Netherlands, 3Gorman Cardiovascular Research Group, University of Pennsylvania, Philadelphia, PA, USA, 4Department of Cardiothoracic Surgery, University of Groningen, Groningen, Netherlands, 5Gorman Cardiovascular Research Group, Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA, 6Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Left Ventricular and Left Atrial Dilation Modify MitraClip Response - Impact of Adverse Chamber Remodeling on Mitral Regurgitation (MR) Recurrence following Percutaneous Mitral Valve Repair
Lisa Q. Rong, MD1, Javid Alakbarli, MD1, Meridith P. Pollie, BS1, Richard B. Devereux, MD1, Shing-Chiu Wong, MD1, Geoffrey Bergman, MD1, Omar Khalique, MD2, Antonino Di Franco, MD1, Robert A. Levine, MD3, Mark Ratcliffe, MD4, Jonathan W. Weinsaft, MD1, Jiwon Kim, MD1.
1Weill Cornell Medical College, New York, NY, USA, 2Columbia University Medical Center, New York, NY, USA, 3Massachusetts General Hospital, Boston, MA, USA, 4University of California, San Francisco, San Francisco, CA, USA.
Invited Speaker -
The Future of Imaging: How the Echocardiographer will Guide Optimal MV Repair
Rebecca Hahn, MD
12 minutes talk with 5 minute discussion
Carpentier-Edwards Physio II Annuloplasty Ring for Mitral Valve Repair: Mid-Term Outcome in 501 Consecutive Patients
Franz Sieg, MD, Mateo Marin Cuartas, MD, Ricardo Spampinato, MD, Philipp Kiefer, MD, Fabian Emrich, MD, David Holzhey, MD PhD, Martin Misfeld, MD PhD, Piroze Davierwala, MD, Michael A. Borger, MD PhD, Jörg Seeburger, MD PhD, Thilo Noack, MD.
Herzzentrum Leipzig, Leipzig, Germany.
Percutaneous Mitral Valve Repair with Mitraclip System in Patients with Severe Left Ventricular Dysfunction: Safety and Outcomes
Laura Sanchis, Xavier Freixa, Marco Hernández-Henríquez, Ander Regueiro, Manel Sabate, Marta Sitges.
Hospital Clinic Barcelona, Barcelona, Spain.
Patient-specific Optimization of Mitral Valve Annuloplasty Surgery
Amir H. Khalighi1, Bruno V. Rego1, Andrew Drach1, Robert C. Gorman2, Jospeh H. Gorman, III2, Michael S. Sacks1.
1The University of Texas at Austin, Austin, TX, USA, 2University of Pennsylvania, Philadelphia, PA, USA.
12:00 - 1:30
12:00 - 1:30
Valve Science Abstracts: Advances in Modeling Valve Disease In Vitro and In Vivo
Moderators: Joy Lincoln, PhD and Muralidhar Padala, PhD
Discussants: Philippe Sucosky, PhD, Patrick Mathieu, MD
Activated Platelets enhance the Progression Of Calcific Aortic Valve Stenosis
Rihab BOUCHAREB1, Marie-Chloe Boulanger2, Lionel Taste1, Ghada Mkannez1, Mohamed J Nsaibia1, Fayez Hadji1, Abdellaziz Dahou1, Younes Messaddeq3, Benoit J Arsenault1, Philippe Pibarot1, Yohan Bosse1, Andre Marette1, Patrick Mathieu1.
1quebec heart and lung institute, quebec, QC, Canada, 2Quebec heart and lung institute, quebec, QC, Canada, 3Laval university, quebec, QC, Canada.
Targeting nuclear Export To Attenuate Aortic Valve Calcification
Punashi Dutta, Joy Lincoln.
Nationwide Children's Hospital, Columbus, OH, USA.
A Gain-of-Function Mutation in CaV1.2 (Cacna1c) Promotes Progressive Aortic Valve Stenosis in Mouse
Maiko Matsui, Mara Storto, Yasin Hussain, Daniel Sinden, Geoffrey S. Pitt.
Weill Cornell Medicine, New York, NY, USA.
Exocyst Mutations Contribute To Cardiac Valvular Disease Through Impaired Ciliogenesis
Diana B. Fulmer1, Katelynn A. Toomer1, Lilong Guo1, Kelsey S. Moore1, Janiece S. Glover1, Simon C. Body2, Joshua H. Lipschutz1, Russell A. Norris1.
1Medical University of South Carolina, Charleston, SC, USA, 2Brigham and Women's Hospital, Boston, MA, USA.
Phenotyping of the First and Unique Knock-In Animal Model for Mitral Valve Prolapse: the FLNA-P637Q KI Rat
Romain Capoulade, Solena Le Scouarnec, Benjamin Lauzier, Simon Lecointe, Joelle Veziers, Richard Redon, Thierry Le Tourneau, Jean-Jacques Schott, Jean Mérot.
l'institut du thorax, Nantes, France.
Ice-free Cryopreserved Heart Valves: A Novel Decellularization and Heart Valve Replacement Method for Pediatrics?
Anna C. Biermann1, Julia Marzi2, Julian L. Wichmann3, Eike Nagel4, Kelvin GM Brockbank5, Katja Schenke-Layland6, Ulrich A. Stock1.
1Department of Cardiothoracic Surgery, Royal Brompton and Harefield Foundation Trust, Harefield, United Kingdom, 2Department of Women's Health, Research Institute for Women's Health, Eberhard-Karls-University, Tuebingen, Germany, 3University Hospital Frankfurt Goethe University, Frankfurt am Main, Germany, 4Department of Diagnostics and Interventional Radiology, University Hospital Frankfurt Goethe University, Frankfurt am Main, Germany, 5The Georgia Tech/Emory Center for the Engineering of Living Tissues, Georgia Institute of Technology, Atlanta, GA, USA, 6Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB), Department of Cell and Tissue Engineering, Stuttgart, Germany.
12:00 - 1:30
VRN Meeting

AVIATOR - Medical
1:30 - 3:00
5 Concurrent Sessions
Aortic Valve Disease Track
Mitral Tricuspid Track
Valve Science Track
Special Topics Track
Abstract Session - Aortic Valve

1:30 - 2:15
Transcatheter Aortic Valve Replacement (TAVR) Updates 2018
Moderators: Howard Herrmann, MD and Susheel Kodali, MD
Discussants: Megan Coylewright, MD, Brij Maini, MD, Isaac George, MD, Joseph Bavaria, MD, Danny Dvir, MD
1:30 - 1:38
What Are the Current Limitations of TAVR?
Martin B. Leon, MD
1:38 - 1:46
Should All TAVR Valves be Treated with Anti-Coagulation Therapy?
Raj Makkar, MD
1:46 - 1:54
Considerations in Choosing a TAVR Prosthesis - Are They All the Same?
Howard Herrmann, MD
1:54 - 2:02
Valve-in-Valve TAVR - Who are the Best and Worst Candidates?
Danny Dvir, MD
2:02 - 2:10
TAVR in Underserved Geographies - What is the Potential?
Hanneke Takkenberg, MD, PhD
2:10 - 2:15
2:15 - 3:00
Expanding Indications for Aortic Valve Therapy
Moderators: Philippe Pibarot, DVM, PhD and Allan Schwartz, MD
Discussants: Ori Ben-Yehuda, MD, Philippe Genereux, MD, Michael Mack, MD, Craig R. Smith, MD, Rakesh Suri, MD, Paul Sorajja, MD
2:15 - 2:25
Moderate AS, With and Without LV Dysfunction
Ori Ben-Yehuda, MD
2:25 - 2:35
Management of Asymptomatic Severe AS
Philippe Genereux, MD
2:35 - 2:45
Classical and Paradoxical Low-Flow, Low-Gradient Aortic Stenosis
Philippe Pibarot, DVM, PhD
2:45 - 2:55
Assessing the Myocardial Response to Aortic Valve Disease: Are We Intervening Too Late?
Julio Chirinos, MD, PhD
2:55 - 3:00

1:30 - 2:20
Mitral Regurgitation Therapy I - Current Standards and Future Directions
Moderators: Paul Sorajja, MD and Patrick McCarthy, MD
Discussants: Brij Maini, MD, Susheel Kodali, MD, D. Craig Miller, MD, Randy Martin, MD, and Vinayak Bapat, MD
1:30 - 1:42
Update on Current Surgical Approaches to the Mitral Valve
Stephanie Mick, MD
1:42 - 1:44
1:44 - 1:54
MitraClip for Complex Anatomies - Clefts, Flails, Commissural MR and More
Brij Maini, MD
1:54 - 1:56
1:56 - 2:06
Promising New Transcatheter Mitral Repair Therapies
Mark Reisman, MD
2:06 - 2:08
2:08 - 2:18
Promising New Transcatheter Mitral Replacement Therapies
Paul Sorajja, MD
2:18 - 2:20
2:20 - 3:00
Mitral Regurgitation Therapy II - Controversial Case-Based Studies
Moderators: Rakesh Suri, MD and Mark Reisman, MD
Discussants: Didier Loulmet, MD, Mayra Guerrero, MD, Mathew Williams, MD, Brij Maini, MD, Gilles Dreyfus, MD, Jeffrey Borer, MD
2:20 - 2:25
Case #1
Primary MR with a Dilated Annulus Presenter: Brij Maini, MD
2:25 - 2:30
2:30 - 2:35
Case #2
MR with Severe MAC
Presenter: Mayra Guerrero, MD
2:35 - 2:40
2:40 - 2:45
Case #3
P3 Leaflet Flail and Severe MR
Presenter: Matthew Williams, MD
2:45 - 2:50
2:50 - 2:55
Case #4
Bi-leaflet Prolapse and Severe MR
Rebecca T. Hahn, MD
2:55 - 3:00

1:30 - 3:00
Tissue Engineering and New Technologies
Moderators: Carlijn Bouten, PhD and Petra Mela, PhD
Discussants: David Kalfa, MD, PhD, Juan Granada, MD, Zeeshan Syedain, PhD, Laura Iop, PhD, Maria Romero, MD, Peter Zilla, MD
1:30 - 1:45
Next Generation Engineered Heart Valves and their Clinical Translation
Zeeshan Syedain, PhD
1:45 - 1:48
1:48- 2:03
Valve Tissue Engineering Imperatives - sterilization, Decellularization, and Banking
Laura Iop, PhD
2:03 - 2:06
2:06 - 2:21
Multiscale fiber-based solutions for biohybrid heart valve tissue engineering
Petra Mela, PhD
2:21 - 2:24
2:24 - 2:39
Endogenous Tissue Restoration: Experimental Aortic Valve Findings (hemodynamics, gross pathology, and histology)
Maria Romero, MD
2:39 - 2:42
2:42 - 2:57
The Requirements for a New Tissue Engineered Valved Device for Children: Clinical, Engineering, Business and Regulatory Perspectives
David Kalfa, MD, PhD
2:57 - 3:00

1:30 - 3:00
Personalized Diagnosis and Treatment of Valvular Heart Disease
Moderators: Robert Levine, MD, Elazer Edelman, MD, PhD, Russell Norris, MD,
Discussants: Juan Granada, MD, Eric Van Belle, MD, PhD, Evaldas Girdauskas, MD, Didier Loulmet, MD, Isaac George, MD
1:30 - 1:40
The Use of Artificial Intelligence in Structural Heart Disease: Tailoring Treatment to the Patient
Juan Granada, MD
1:40 - 1:50
Genetics of Mitral Valve Prolapse: New Insights
David Milan, MD
1:50 - 2:00
Familial Screening for Mitral Valve Disease: When and Why?
Robert Levine, MD
2:00 - 2:10
Genetics of Bicuspid Aortic Valve Disease: Clinical Implications
Richard Devereux, MD
2:10 - 2:20
Morphometric Variants of Bicuspid Aortic Valve Disease and Associated Aortic Aneurysmal Dilatation
Evaldas Girdauskas, MD
2:20 - 2:30
Biomarkers in Mitral Regurgitation
Rodolfo Pizarro, MD
2:30 - 2:40
Aortic Stenosis and Von Willebrand Factor: from Heyde's Syndrome to TAVR
Eric Van Belle, MD, PhD
2:40 - 2:50
Circulating RNA in Valvular Heart Disease
Magnus Back, MD, PhD
2:50 - 3:00

1:30 - 3:00
Tricuspid Valve
Moderators: Isaac George, MD, Paul Sorajja, MD
Discussants: Stephanie Mick, MD, Yan Topilsky, MD, Giovanni Ferrari, MD and Maurizio Taramasso, MD
Functional Tricuspid Regurgitation In Patients With Systolic Left Ventricular Dysfunction: Determinants, And Independent Prognostic Impact.
Giovanni Benfari, MD1, Clemence Antoine, MD1, Wayne L. Miller, MD, PhD1, Prabin Thapa, BS1, Andrea Rossi, MD2, Hector I. Michelena, MD1, Vuysile T. Nkomo, MD, PhD1, Maurice Enriquez-Sarano, MD1.
1Mayo Clinic, Rochester, MN, USA, 2University of Veorna, Section of cardiolgy, Italy.
Carpentier-Chauvaud-Cone Repair For Ebstein Anomaly: Three Decades Of Experience
Kevin M. Veen, Mostafa M. Mokhles, Jolien W. Roos-Hesselink, Bas R. Rebel, Johanna J.M. Takkenberg, Ad J.J.C. Bogers.
Erasmus MC, Rotterdam, Netherlands.
Can we Repair The Organic Tricuspid Valve Lesions. Five Years Follow up and Multi-centric Study.
Marwan H. Elkassas1, Hany Faisal1, Hasan Salah1, Osama A. Abbas2, Mohamed Hagag3.
1Suez Canal University, Cairo, Egypt, 2Ain Shams University, Cairo, Egypt, 3Menoufia, Menoufia, Egypt.
Comparison Of Three Dimensional Echocardiographic Measurements And In Vivo Analysis Of The Tricuspid Valve During Mitral Valve Surgery
Matteo Pettinari1, Siham Lazam2, Laurent De Kerchove2, Agnes Pasquet2, Bernard Gerber2, Gebrine El-Khoury El-Khoury2, Jean-Louis Vanoverschelde2.
1Ziekenhuis Oost Limburg, Genk, Belgium, 2Universitair Clinique St. Luc, Brussel, Belgium.
Invited Speaker -
How Do I Choose Between Surgical or Transcatheter TV Repair: Patient Selection Criteria
Vinayak Bapat, MD
12 minutes talk with 5 minute discussion
Recovery Of Right Ventricular Function After Tricuspid Annuloplasty For Functional Tricuspid Regurgitation In Patients Undergoing Mitral Valve Repair For Mitral Regurgitation
Yukikatsu Okada, Ryousuke Funahashi, Takashi Muro, Hitoshi Inanami, Tomoyuki Takemoto, Megumi Takahashi, Fumiaki Maenishi.
Midori Hospital, Kobe, Japan.
PISA Underestimates TR Severity In Patients With Functional TR
Abdellaziz Dahou1, Geraldine Ong2, Nadira Hamid2, Eleonora Avenatti2, Jing Yao2, Rebecca T. Hahn1.
1Cardiovascular Research Foundaion; Columbia University, New York, NY, USA, 2Cardiovascular Research Foundaion, New York, NY, USA.
Early And Mid-term Outcomes Of Surgical Treatment Of Tricuspid Valve Endocarditis In Patients With Intravenous Drug Abuse
Kenji Minakata, William Moser, Gengo Sunagawa, Mark Mitchell, Fatuma Kromah, Suresh Keshavamurthy, Jesus Gomez-Abraham, Yoshiya Toyoda.
Temple University, Philadelphia, PA, USA.
3:00 - 3:30
Coffee Break
3:30 - 5:30
Plenary Session IV: Innovative Aortic Valve Therapies
Moderators: Vinod H. Thourani, MD and Susheel Kodali, MD
Discussants: Emmanuel Lansac, MD, Jonathon Leipsic, MD, Raj Makkar, MD, Tirone David, MD, Martin B. Leon, MD, David Wood, MD, Michael Mack, MD
3:30 - 4:00
Live Case Demonstration from the Cleveland Clinic
4:00 - 4:15
Featured Lecture: The Power of the AVIATOR Database in Aortic Valve Repair
Emmanuel Lansac, MD
4:15 - 4:20
4:20 - 4:35
Featured Lecture: The Future Role of Surgery in Low-Risk Aortic Stenosis Patients
Vinod Thourani, MD
4:35 - 4:45
Is the "Minimalist" TAVR Strategy Generalizable? Results of the 3M Study
David Wood, MD
4:45 - 4:50

Controversy: Managing Bicuspid Aortic Valve Disease
4:50 - 5:00
CT Imaging Diagnosis of Bicuspid Aortic Valves
Jonathon Leipsic, MD
5:00 - 5:10
Surgical Management of the Bicuspid Aortic Valve and Associated Aortopathy
Tirone David, MD
5:10 - 5:20
Transcatheter Management of Bicuspid Aortic Valve Stenosis
Raj Makkar, MD
5:20 - 5:30
Saturday, April 14th
7.00 - 8.00
VRN Meetings
8:00 - 9:30
5 Concurrent Sessions
Aortic Valve Disease Track
Mitral Tricuspid Track
Valve Science Track
Special Topics Track
Abstract Session - Aortic Valve

8:00 - 8:45
Management of Aortic Regurgitation
Moderators: Hanneke Takkenberg, MD, PhD, Michael Borger, MD
Discussants: Jeffrey Borer, MD, Emmanuel Lansac, MD, Hendrik Treede, MD, Raj Makkar, MD, and Danny Dvir, MD, Mostafa Mokhles, MD
8:00 - 8:08
AR Management: from Epidemiology to Personalized Decision Making.
Jeffrey Borer, MD
8:08 - 8:16
MRI for AR Quantification - Where are We Now?
Steven Wolff, MD
8:16 - 8:24
State-of-the-Field: Bicuspid Valve Repair for AR
Joseph Bavaria, MD
8:24 - 8:32
Transcatheter Approaches to Aortic Insufficiency
Hendrik Treede, MD
8:32 - 8:40
Novel Surgical Approaches to AR
Michael Borger, MD
8:40 - 8:45
8:45 - 9:30
Imaging and Tissue Engineering of the Aortic Valve
Moderators: Simon Hoerstrup, MD, PhD, Carlijn Bouten, PhD
Discussants: Mehran Sadeghi, MD, David Kalfa, MD, PhD, Ori Ben-Yehuda, MD, and Jeffrey Borer, MD
8:45 - 8:53
Echocardiographic evaluation of left ventricular function in AS
Randy Martin, MD
8:53 - 9:01
Assessing Myocardial Viability and Function in AS - Is CMR the New Gold Standard?
Jonathan Weinsaft, MD
9:01 - 9:09
Molecular imaging of CAVD
Mehran Sadeghi, MD
9:09 - 9:17
Translating Heart Valve Tissue Engineering to the Clinic
Simon Hoerstrup, MD, PhD
9:17 - 9:25
Novel Perspectives in Heart Valve Tissue Engineering
Carlijn Bouten, PhD
9:25 - 9:30

8:00 - 9:00
Tricuspid Regurgitation Therapy I - Current Standards and Future Directions
Moderators: Gilles Dreyfus, MD and Vinayat Bapat, MD,
Discussants: Eugene Grossi, MD, Ori Ben-Yehuda, MD, Michael Borger, MD, Susheel Kodali, MD
8:00 - 8:12
Update on Current Surgical Approaches to the Tricuspid Valve
Gilles Dreyfus, MD
8:12 - 8:15
8:15 - 8:27
Should ALL Patients with "Significant" TR be Repaired at the Time of Mitral Valve Surgery
Eugene Grossi, MD
8:27 - 8:30
8:30 - 8:42
Update on Promising New Transcatheter Tricuspid Valve Therapies
Susheel Kodali, MD
8:42 - 8:45
8:45 - 8:57
Is there a Role for Transcatheter Tricuspid Valve Replacement?
Vinayat Bapat, MD
8:57 - 9:00
9:00 - 9:30
Tricuspid Regurgitation Therapy II - Controversial Case-Based Studies
Moderators: Maurizio Taramasso, MD and Rebecca T. Hahn, MD
Discussants: Vinod Thourani, MD, Randy Martin, MD, Milind Desai, MD, Brij Maini, MD
9:00 - 9:05
Case #1
Functional TR with a Dilated Annulus
Presenter: Peter Fail, MD
9:05 - 9:10
9:10 - 9:15
Case #2
TR Secondary to PPM Lead Entrapment
Presenter: Milind Desai, MD
9:15 - 9:20
9:20 - 9:25
Case #3
Tricuspid Clipping for severe TR
Presenter: Gilbert Tang, MD
9:25 - 9:30

8:00 - 9:30
The Big Picture: Valve Disease and the Heart – Empire State V
Moderators: Elaine Tseng, MD and Jane Grande-Allen, PhD
Discussants: T. Sloane Guy, MD, Liang Ge, MD, Philippe Genereux, MD, David Adams, MD, Murali Padala, PhD
8:00 – 8:15
Cardiac Outcomes of Degenerative Mitral Regurgitation
T. Sloane Guy, MD
8:15 – 8:18
8:18 – 8:33
Cardiac Changes after Successful Repair for Degenerative Mitral Regurgitation
Dimosthenis Pandis, MD
8:33 – 8:36
8:36 – 8:51
Papillary Muscle Repositioning Effects on the LV in Ischemic MR
Murali Padala, MD
8:51 – 8:54
8:54 – 9:09
Bicuspid Aortic Valve Aneurysms and Timing of Intervention Based on Biomechanics and Molecular Biology Principles
Liang Ge, MD
9:09 – 9:12
9:12 – 9:27
Staging Classification of Aortic Stenosis Based on the Extent of Cardiac Damage
Philippe Genereux, MD
9:27 - 9:30

8:00 - 9:30
Controversies in Valvular Heart Disease II
Moderators: Manuel Antunes, MD and Emile Bacha, MD
Discussants: David Kalfa, MD, PhD., Matthew Crystal, MD, L. Prasad Dasi, MD, Giovanni Ferrari, MD, John Puskas, MD, Vinayat Bapat, MD
8:00 - 8:10
Pathomechanistic Insights into Prosthetic Valve Thrombosis
Hoda Hatoum
8:10 - 8:20
Anticoagulation After Biological AVR: Necessary or Not?
Michael Mack, MD
8:20 - 8:30
Pediatric Heart Valve Biology and Mechanobiology: Why Does a Biological Valve Degenerate so Quickly in Children?
Giovanni Ferrari, MD
8:30 - 8:40
Valve Repair for Rheumatic Heart Disease: Indications and Outcomes
Manuel Antunes, MD
8:40 - 8:50
Valve-Sparing Surgery for Tetralogy of Fallot
Emile Bacha, MD
8:50 - 9:00
Transcatheter Management of Pediatric Heart Valve Disease: Current Status and Future Directions
Matthew Crystal, MD
9:00 - 9:10
Tissue Engineering for Pediatric Heart Valve Disease: Ready for Prime Time?
David Kalfa, MD
9:10 - 9:20
Incidence and Management of GUCH Valvular Heart Disease
Ingo Daehnert, MD
9:20 - 9:30

8:00 - 9:30
Moderators: Brij Maini, MD, David Holzhey, MD and Vinod Thourani, MD
Discussants: Mathew Williams, MD, Ezequiel Molina, MD, and Martin B. Leon, MD
Echocardiographic Markers of Secondary Mitral Regurgitation Recurrence After Combined Mitral Valve Repair and Papillary Muscle Approximation
Christos G. Mihos1, Francesco Nappi2, Romain Capoulade3, Massimo Chello4, Raffaele Barbato4, Orlando Santana1.
1Columbia University Division of Cardiology, Mount Sinai Heart Institute, Miami Beach, FL, USA, 2Centre Cardiologique du Nord de Saint-Denis, Paris, France, 3Institut du Thorax, Inserm, CNRS, Université de Nantes, CHU Nantes, Nantes, France, 4University Campus Bio-Medico of Rome, Rome, Italy.
Sildenafil for the Treatment of Pulmonary Hypertension in the Early Postoperative Period after Mitral Valve Surgery
Eilon Ram, Leonid Sternik, Eyal Nachum, Robert Klempfner, Dina Kogan, Michael Eldar, Ilan Goldenberg, Ehud Raanani, Alexander Kogan.
Sheba Medical Center, Israel, Jerusalem, Israel.
Is Transcatheter Aortic Valve Replacement Better than Surgical Aortic Valve Replacement in Patients with Chronic Obstructive Pulmonary Disease? A Nationwide Inpatient Sample Analysis
Tomo Ando1, Oluwole Adegbala2, Emmanuel Akintoye1, Said Ashraf3, Luis Afonso3, Theodore Schreiber3.
1Detroit Medical Center, Troy, MI, USA, 2Englewood Hospital and Medical Center, Englewood, NJ, USA, 3Detroit Medical Center, Detroit, MI, USA.
Detecting Early Bioprosthetic Valve Degeneration with 18F-Fluoride PET-CT
Timothy RG Cartlidge1, Mhairi K. Doris1, Tania A. Pawade1, Audrey C. White1, Renzo Pessotto1, James HF Rudd2, Edwin van Beek1, David E. Newby1, Marc R. Dweck1.
1University of Edinburgh, Edinburgh, United Kingdom, 2University of Cambridge, Cambridge, United Kingdom.
Transcatheter Aortic Valve Implantation for Patients with Bicuspid Aortic Valves. Still a contraindication?
Mirko Doss, Thomas Walther.
Kerckhoff Heart Center, Bad Nauheim, Germany.
N-terminal pro B type natriuretic peptide is superior to B-type natriuretic peptide to predict mortality in Classical Low Flow, Low Gradient Aortic Stenosis
Mohamed Salah Annabi1, Abdellaziz Dahou1, Jutta Bergler-Klein2, Ian G. Burwash3, Stefan Orwat4, Helmut Baumgartner4, Philip Bartko2, Julia Mascherbauer2, Gerald Mundigler2, Philippe Pibarot1, Marie-Annick Clavel1.
1Quebec Heart and Lung Institute, Québec-ville, QC, Canada, 2Vienna General Hospital, Vienna, Austria, 3Ottawa Heart Institute, Ottawa, ON, Canada, 4University Hospital of Muenster, Muenster, Germany.
Impact of the Renin-Angiotensin System Activation on the Progression Rate of Aortic Stenosis
Mylčne Shen, Lionel Tastet, Romain Capoulade, Marie Arsenault, Elisabeth Bédard, Philippe Pibarot, Marie Annick Clavel.
Quebec Heart and Lung Institute, Quebec City, QC, Canada.
Incidence and Prognostic Implications of Thrombocytopenia in Patients Undergoing Transcatheter versus Surgical Aortic Valve Replacement - A Sub-Analysis from the PARTNER IIA Randomized Trial
Pablo Coder1, Matthew T. Finn1, Aakriti Gupta1, Aaron Crowley2, Jacob Cleman1, Susheel Kodali1, Hasan Jilaihawi3, Raj Makkar4, Danny Dvir5, Philippe Genereux2, Augusto Pichard6, James McCAbe5, Howard Herrman7, Zachary Gertz8, Brian Lindman9, Brian O"Neiil10, Vinod Thourani6, Michael Mack11, Craig R. Smith1, Martin B. Leon1, Ajay J. Kirtane1.
1Columbia Univeristy Medical Center, New York, NY, USA, 2Cardiovascular Research Foundation, New York, NY, USA, 3New York University, New York, NY, USA, 4Ceders Sinai, Los Angeles, CA, USA, 5University of Washington, Seattle, WA, USA, 6Medstar Washington Hospital Center, Washington, DC, USA, 7Univesity of Pennsylvania, Philadelphia, PA, USA, 8Virginia Commonwealth, Richmond, VA, USA, 9Vanderbilt, Nashville, TN, USA, 10Temple University, Philadelphia, PA, USA, 11Baylor Scott and White, Plano, TX, USA.
Pulmonary Allograft Extension with Decellularized Human Pericardium Improves Hemodynamic Function after the Ross Operation
Francisco D A Costa1, Angelo Cabral1, Claudinei Colatusso1, Eduardo M. Balbi Filho1, Rafael Torres1, Gabriela M. Schorn1, Joao Gabriel Roderjan2, Paula H. Suss2.
1INC Cardio, Curitiba, Brazil, 2PUCPR, Curitiba, Brazil.
9:30 - 10:00
Coffee Break
Challenging Cases - Columbia
Moderators: Rebecca Hahn, MD, and Susheel Kodali, MD
Discussants: Michael Borger, MD, Vinod Thourani, MD, Vinayak Bapat, MD, Amisha Patel, MD, Martin B. Leon, MD
Valve-in-MAC: A Tale of Two Cases - Stretched to the Limit (and beyond)
Susheel Kodali, MD

A Last Resort for Torrential TR: Navigate TTVR
Vinayak Bapat, MD

An Unexpected Visitor: Rheumatic MS and AS Treated by PTMC and TAVR
Amisha Patel, MD

TAVR for AR (Following Redo MVR) - Why and How To
Martin B. Leon, MD

A Flail Without Mercy: MitraClip for Ruptured Papillary Muscle following AMI
Susheel Kodali, MD
11:00 - 12:00
Challenging Cases - Mayo
Moderator: Maurice Sarano, MD

Young adult S/P Ross with Failing Aortic Bioprosthetic Valve and Pulmonary Homograft
Allison Cabalka, MD

WTF? (Why This coaptation Failure?)
Hector Michelena, MD

The Missing Piece of the Puzzle (MR case)
Sorin Pislaru, MD

An Unbearable Annular Calcification (treated by LA-LV graft)
Simon Maltais, MD

Underappreciating Severe Aortic Stenosis in Patients with Atrial Fibrillation: The Case Against Averaging Signals
Vuyisile T. Nkomo, MD, MPH
12:00 - 12:30
Grab and Go Lunch Break
12:30 - 2:00
12:30 - 2:00
Valve Science Session and Abstracts: Biomechanics and Mechanobiology in Valve Development and Disease
Moderators: L. Prasad Dasi, PhD and Manuel Rausch, PhD
Discussants: Carla Lacerda, PhD, Jane Grande-Allen, PhD, Wei Sun PhD
12:00 - 12:12
Bioprosthetic Valves, Fluid Mechanics, and Thrombosis
L. Prasad Dasi, PhD
12:12 - 12:15
12:15 - 12:27
Tricuspid Valve Kinematics in Health, Disease, and After Repair
Manuel Rausch, PhD
12:27 - 12:30
12:30 - 12:42
Interactome Analysis of Valve Cell Mechanobiology
Carla Lacerda, PhD
12:42 - 12:45
Mechano-osmotic Stress Regulates Compaction and Elongation of the Fetal AV Valve in Collaboration with Developed Matrix Scaffolding
David M. Bassen, Duc Pham, Rashmi Rao, Jonathan T. Butcher
Cornell University, Ithaca, NY, USA.
Bone Morphogenic Protein Inhibition Attenuates Bicuspid Aortic Valve Flow-Mediated Remodeling and Inflammation in Vitro
Samantha K. Atkins1, Johana Barrientos2, Philippe Sucosky2.
1University of Notre Dame, Notre Dame, IN, USA, 2Wright State University, Dayton, OH, USA.
Quantifying Infarction-induced Changes in Mitral Valve Geometry and Deformation Using 3D Echocardiography
Bruno V. Rego1, Amir H. Khalighi1, Robert C. Gorman2, Joseph H. Gorman, III2, Michael S. Sacks1.
1University of Texas at Austin, Austin, TX, USA, 2University of Pennsylvania, Philadelphia, PA, USA.