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Program and Abstracts | ICTEHV | Posters | Display Posters
Wednesday, 29 March 2023
8:30am to 5:15pm
ICTEHV Conference
8:30am to 8:45am
Opening & Welcome
Dr. Jesper Hjortnaes, ICTEHV Chair
Dr. Jesper Hjortnaes, ICTEHV Chair
8:45am to 10:15am
Session 1: Replacing the living valve - pathophysiological remodeling
Chairs: Dr. Joshua Hutcheson & t.b.d.
Chairs: Dr. Joshua Hutcheson & t.b.d.
8:45-9:10
Invited Lecture: The Ross Procedure – The Ideal Living Valve?
Prof. Ismail El-Hamamsy
Prof. Ismail El-Hamamsy
9:10-9:30
Invited Lecture: Bicuspid aortic valves: Embryonic development and adult pathology
Dr. Borja Fernandez
Dr. Borja Fernandez
9:30-10:50
Invited Lecture: Aortopathies resulting from bicuspid aortic valve malformations
Dr. Julie Phillippi
Dr. Julie Phillippi
9:50-10:15
Invited Lecture: Emergent mechanisms of aortic valve homeostasis and calcification
Prof. Jonathan Butcher
Prof. Jonathan Butcher
10:15am to 10:45am
Coffee Break
10:45am to 12:20pm
Session 2: The future of HVTE (sponsored by the Materials-Driven Regeneration program)
10:45-10:50
Introduction MDR-consortium & session opening
Dr. Anthal Smits
Dr. Anthal Smits
10:50-11:15
Invited Lecture: Engineering biomaterials for sex-specific cardiovascular tissue engineering
Dr. Brian Aguado
Dr. Brian Aguado
11:15-11:27
i3. Inflammation-driven Calcification In Materials For Valvular In Situ Tissue Engineering
Dewy C. van der Valk, Yunia M.H. Rasenberg, Romee van Schijndel, Anat Akiva, Anthal I.P.M. Smits, Carlijn V.C. Bouten
Dewy C. van der Valk, Yunia M.H. Rasenberg, Romee van Schijndel, Anat Akiva, Anthal I.P.M. Smits, Carlijn V.C. Bouten
11:27-11:39
i16. Cellular and Extracellular Vesicle Proteomes of 3D-Bioprinted Aortic Valve Disease Model Compared to Native Valves and 2D Culture
Cassandra L. Clift, Mark C. Blaser, Willem Gerrits, Tan Pham, Mandy E. Turner, Jason L. Andresen, Owen S. Fenton, Joshua M. Grolman, Fabrizio Buffolo, David J. Mooney, Jesper Hjortnaes, Jochen D. Muehlschlegel, Masanori Aikawa, Sasha A. Singh, Robert Langer, Elena Aikawa
Cassandra L. Clift, Mark C. Blaser, Willem Gerrits, Tan Pham, Mandy E. Turner, Jason L. Andresen, Owen S. Fenton, Joshua M. Grolman, Fabrizio Buffolo, David J. Mooney, Jesper Hjortnaes, Jochen D. Muehlschlegel, Masanori Aikawa, Sasha A. Singh, Robert Langer, Elena Aikawa
11:39-11:51
i20. Longitudinal Quantitative Monitoring Of VEC Role In 3D CAVD Co-culture Lesion Formation.
Katherine Driscoll, Hrishika Gogineni, Andrea Huang, Jennifer Richards, Santosh Balakrishnan, Meg McFetridge, Steven Adie, Jonathan Butcher.
Katherine Driscoll, Hrishika Gogineni, Andrea Huang, Jennifer Richards, Santosh Balakrishnan, Meg McFetridge, Steven Adie, Jonathan Butcher.
11:55am-11:20am
Young Talent Poster Flash Talks
11:55-11:59
Poster Abstract I (i11) - In-vitro Real-time Wear Assessment Of Cellular Porcine Pulmonary Valve Roots
Izat Fatima, Amisha Desai, Helen Berry, Louise Jennings
Izat Fatima, Amisha Desai, Helen Berry, Louise Jennings
12:00-12:04
Poster Abstract II (i12) - Advances In The Clinical Translation Of Human Tissue-engineered Matrices - A Safety Substitute For Fetal Bovine Serum In Tissue-engineering Applications
Polina Zaytseva, Sarah E. Motta, PhD, Simon P. Hoerstrup, MD, PhD, Maximilian Y. Emmert
Polina Zaytseva, Sarah E. Motta, PhD, Simon P. Hoerstrup, MD, PhD, Maximilian Y. Emmert
12:05-12:09
Poster Abstract VII (i19) – An Innovative Culturing Method of an Alginate-Based Hydrogel Aortic Valve Substitute with Native-Like Geometry
Y. Rioux, A. Bégin-Drolet, C.J. Hayward, Y. Maciel, J. Fradette, J. Ruel.
Y. Rioux, A. Bégin-Drolet, C.J. Hayward, Y. Maciel, J. Fradette, J. Ruel.
12:10-12:14
Poster Abstract III (i13) – A Biomechanical And Mechanobiological Analysis Of In-situ Tissue-engineered Heart Valves
Elmer Middendorp, Sylvia Dekker, Bente J. de Kort, Arturo Lichauco, Carlijn V.C. Bouten, Frank P.T. Baaijens, Sandra Loerakker, Anthal I.P.M. Smits
Elmer Middendorp, Sylvia Dekker, Bente J. de Kort, Arturo Lichauco, Carlijn V.C. Bouten, Frank P.T. Baaijens, Sandra Loerakker, Anthal I.P.M. Smits
12:15-12:19
Poster Abstract V (i15) - Novel In-Vitro Platform To Simulate The Early Host Response Of In Situ Engineered Heart Valves
V.C. Vetter, D.M. Ibrahim, A. Niewchas, J.E. Mayer, A.I.P.M. Smits, C.V.C. Bouten
V.C. Vetter, D.M. Ibrahim, A. Niewchas, J.E. Mayer, A.I.P.M. Smits, C.V.C. Bouten
12:20 to 2:00pm
Lunch and Poster Session
2:00pm to 3:25pm
Session 3: Rationally engineered scaffold designs
2:00-2:25
Invited Lecture: Additive Manufacturing To Engineer Mechanically Defined TEHVs
Prof. Petra Mela
Prof. Petra Mela
2:25-2:37
i5 Programmable Melt Electrowriting To Engineer Heart Valve Tissues With Prescribed, Biomimetic Biaxial Mechanical Properties
Bahram Mirani, Neda Latifi, Sean Mathew, Michel Labrosse, Brian Amsden, Craig Simmons
Bahram Mirani, Neda Latifi, Sean Mathew, Michel Labrosse, Brian Amsden, Craig Simmons
2:37-2:49
i6 Comparing The Performance And Remodeling Of Tissue Engineered Heart Valve Designs Using Computational Models
Valery L. Visser, Sarah E. Motta, Simon P. Hoerstrup, Sandra Loerakker, Maximilian Y. Emmert
Valery L. Visser, Sarah E. Motta, Simon P. Hoerstrup, Sandra Loerakker, Maximilian Y. Emmert
2:49-3:01
i17. Feasibility of Hybrid Tissue-Engineered Mitral Valve
Ramin Zareian, Sam Zuke, Daisuke Morisawa, Roger Geertsema, Mariwan Majid, Clinton Wynne, Jeffrey C. Milliken, Arash Kheradvar
Ramin Zareian, Sam Zuke, Daisuke Morisawa, Roger Geertsema, Mariwan Majid, Clinton Wynne, Jeffrey C. Milliken, Arash Kheradvar
3:01-3:13
i7. A Bioinspired Bizonal Mitral Valve Scaffold Via Melt Electrowriting
Kilian Maria Arthur Mueller, Paula Castejón Echevarne, Matthias Pixner, Petra Mela.
Kilian Maria Arthur Mueller, Paula Castejón Echevarne, Matthias Pixner, Petra Mela.
3:13-3:25
i4. Fetal Tissue Engineered Pulmonary Valve Replacement - A Biomechanical Study
S. S. Bhat, A. Farnan, H. T. Bui, K. Vietmeyer, A. K. Armstrong, C. K. Breuer, L. P. Dasi
S. S. Bhat, A. Farnan, H. T. Bui, K. Vietmeyer, A. K. Armstrong, C. K. Breuer, L. P. Dasi
3:25pm to 3:55pm
Coffee Break
3:55pm to 5:15pm
Session 4: Making use of nature: ECM-based scaffolds
3:55-4:20
Invited Lecture: ECM-Based Tissue-Engineered Heart Valves
Prof. Robert Tranquillo
Prof. Robert Tranquillo
4:20-4:32
i8 A Novel Method For Cell Delivery In Decellularized Heart Valves Using Injectable Hydrogels
V.C. Vetter, N. Masoumi, Z. Machaidze, M. Gansevoort, J.L. Andresen, O.S. Fenton, A.I.P.M. Smits, C.V.C. Bouten, R. Langer, J.E. Mayer
V.C. Vetter, N. Masoumi, Z. Machaidze, M. Gansevoort, J.L. Andresen, O.S. Fenton, A.I.P.M. Smits, C.V.C. Bouten, R. Langer, J.E. Mayer
4:32-4:44
i9 Monomeric Glutaraldehyde Fixation With Amino Acid Detoxification Of Decellularized Bovine Pericardium: Creating Cardiovascular Scaffolds With Tissue Guided Regeneration Potential?
Angélique Lewies, Lezelle Botes, Johannes J. Van den Heever, Pascal M. Dohmen, Francis E. Smit
Angélique Lewies, Lezelle Botes, Johannes J. Van den Heever, Pascal M. Dohmen, Francis E. Smit
4:44-4:56
i10 Fibrin-Collagen-Glycosaminoglycan Scaffolds For Tissue Engineered Heart Valve Replacement
Jessica Perez, Francisco Almeida-Gonzalez, Arlyng Gonzalez-Vazquez, Fergal J. O'Brien, Claire M. Brougham.
Jessica Perez, Francisco Almeida-Gonzalez, Arlyng Gonzalez-Vazquez, Fergal J. O'Brien, Claire M. Brougham.
4:56-5:08
i2. Living Tissue Engineered Pulmonary Heart Valves For Pediatric Patients
Dan Simionescu, Ionela Movileanu, Marius Harpa, Lucian Harceaga, Alexandru Chertes, Terezia Preda, Hussam Al HusseinHamida Al Hussein, Carmen Sircuta, Ovidiu Cotoi, Dan Nistor, Adrian Man, Horatiu Suciu, Klara Branzaniuc, Margarita Bruce, Megan Casco, Georg Lutter, Thomas Puehler, Radu Deac, Bogdan Cordos, Agneta Simionescu.
Dan Simionescu, Ionela Movileanu, Marius Harpa, Lucian Harceaga, Alexandru Chertes, Terezia Preda, Hussam Al HusseinHamida Al Hussein, Carmen Sircuta, Ovidiu Cotoi, Dan Nistor, Adrian Man, Horatiu Suciu, Klara Branzaniuc, Margarita Bruce, Megan Casco, Georg Lutter, Thomas Puehler, Radu Deac, Bogdan Cordos, Agneta Simionescu.
5:08-5:15
ICTEHV closure
Dr. Jesper Hjortnaes, ICTEHV team
Dr. Jesper Hjortnaes, ICTEHV team
5:15pm to 6:00pm
Reception and Awards
HVS Conference
3:00pm to 5:00pm
Board of Directors Meeting
5:30pm to 7:00pm
Movies & Libations I
Moderators: Rakesh Suri, Ralph Stephan von Bardeleben, Marina Urena
How to do percutaneous annuloplasty
Angel Sanchez Recalde
How to implant a bicaval device to treat TR
Angel Sanchez Recalde
A challeging Tricuspid TEER
Samir Kapadia
Surgical TV Repair
Juan Umana
How to do TMVR
Vinod Thourani
Complex MV Repair
James Gammie
Moderators: Rakesh Suri, Ralph Stephan von Bardeleben, Marina Urena
How to do percutaneous annuloplasty
Angel Sanchez Recalde
How to implant a bicaval device to treat TR
Angel Sanchez Recalde
A challeging Tricuspid TEER
Samir Kapadia
Surgical TV Repair
Juan Umana
How to do TMVR
Vinod Thourani
Complex MV Repair
James Gammie
5:30pm to 7:00pm
Movies & Libations II - Aortic
Moderators: Jessica Forcillo, Samir Kapadia, Victoria Delgado, Emmanuel Lansac
Robotic MICS SAVr
Daniel Pereda
Surgical AV Repair
Jolanda Kluin
TAVR with Basilica
Ander Regueiro
Valve Sparing Aortic surgery
Maral Ouzounian
Treatment of AR with Transcatheter Techniques
Frank van der Kley
Paravalvular Leak Closure
Pradeep Yadav
Moderators: Jessica Forcillo, Samir Kapadia, Victoria Delgado, Emmanuel Lansac
Robotic MICS SAVr
Daniel Pereda
Surgical AV Repair
Jolanda Kluin
TAVR with Basilica
Ander Regueiro
Valve Sparing Aortic surgery
Maral Ouzounian
Treatment of AR with Transcatheter Techniques
Frank van der Kley
Paravalvular Leak Closure
Pradeep Yadav
Thursday, 30 March 2023
9:00am to 10:30pm
Plenary Session I: Presidential Plenary
Moderators: Marta Sitges and Carlijn Bouten
Moderators: Marta Sitges and Carlijn Bouten
9:00-9:15
HVS Business Meeting
9:15-9:30
The Patient's Voice: Building Together the Patient's Pathway
Global Heart Hub - Ellen Ross, Jens Naumann
Global Heart Hub - Ellen Ross, Jens Naumann
9:30-9:45
Keynote - ICHOM Standard for HVD: A Global Initiative to Move From Device to Patient's Centered Outcomes
Emmanuel Lansac & Hanneke Takkenberg
Emmanuel Lansac & Hanneke Takkenberg
9:45-9:55
Lifetime Achievement Award
Introduced by Marta Sitges
Introduced by Marta Sitges
9:55-10:00
Introduction of the HVS President
Carlijn Bouten
Carlijn Bouten
10:00-10:30
Presidential Address – The Old Tales and the New Reality:
Cardiovascular Medicine
Marta Sitges
Cardiovascular Medicine
Marta Sitges
10:30am to 11:00am
BREAK
11:00am to 12:30pm
Breakout Session I: Aortic Valve
Aortic Stenosis: From the Source of the Problem to the Outcomes
Moderators: Philippe Pibarot, Kendra Grubb, Marina Ureña
Aortic Stenosis: From the Source of the Problem to the Outcomes
Moderators: Philippe Pibarot, Kendra Grubb, Marina Ureña
11:00-11:12
Why Calcific Sclerosis Develops
Jordan Miller
Jordan Miller
11:12-11:24
New Targets for Treating Aortic Valve Calcification
Farshad Amirkhosravi
Farshad Amirkhosravi
11:24-11:36
New Tools to Clarify the Diagnosis of Severe Aortic Stenosis
Victoria Delgado
Victoria Delgado
11:36-12:00
Lifetime Management of Aortic Stenosis in Patients under 70 Y.O.:
TAVI First
Kendra Grubb
SAVR First
Pradeep Yadav
Kendra Grubb
SAVR First
Pradeep Yadav
12:00-12:30
Discussion
11:00am to 12:30pm
Breakout Session II: Tricuspid Valve
Advances in Tricuspid Valve Disease
Moderators: Gilles Dreyfus, Michele de Bonis
Advances in Tricuspid Valve Disease
Moderators: Gilles Dreyfus, Michele de Bonis
11:00-11:10
New Epidemiological Data on Tricuspid Valve Disease
Kevin Veen
Kevin Veen
11:00-11:20
Indications for Tricuspid Valve Intervention
Laura Sanchis
Laura Sanchis
11:20-11:30
Development in understanding TR pathophysiology: New TR classification
Marta Sitges
Marta Sitges
11:30-11:40
Tricuspid TEER: The Triluminate study
Vinod Thourani
Vinod Thourani
11:40-11:50
Tricuspid Valve Annuloplasty in Mild to Moderate Tricuspid Regurgitation - Always Required?
James Gammie
James Gammie
11:50-12:00
Percutaneous annuloplasty and transcatheter prosthesis for TR: Update 2023 on outcomes
Ander Regueiro
Ander Regueiro
12:00-12:10
Forecasting New Guidelines Recommendations in Tricuspid Valve Interventions
Victoria Delgado
Victoria Delgado
12:10-12:30
Discussion
11:00am to 12:30pm
Breakout Session III: ABSTRACT COMPETITION I
Basic Biology & Computational Science
Moderators: Prasad Dasi, Murali Padala
Basic Biology & Computational Science
Moderators: Prasad Dasi, Murali Padala
Dysregulated SOX17-PDGFB Signaling Axis Causes Bicuspid Aortic Valve
Pengfei Lu1, Bingruo Wu1, Ping Wang1, Yukiko Sugi2, Jonathan T. Butcher3, Deyou Zheng1, Bin Zhou1.
1Albert Einstein College of Medicine, Bronx, NY, USA, 2Medical University of South Carolina, Charleston, SC, USA, 3Cornell University, Ithaca, NY, USA.
Pengfei Lu1, Bingruo Wu1, Ping Wang1, Yukiko Sugi2, Jonathan T. Butcher3, Deyou Zheng1, Bin Zhou1.
1Albert Einstein College of Medicine, Bronx, NY, USA, 2Medical University of South Carolina, Charleston, SC, USA, 3Cornell University, Ithaca, NY, USA.
Genetic Haploinsufficiency Of Sirtuin 6 Accelerates Progression Of Fibro-calcific Aortic Valve Disease (FCAVD)
Marten AttaAlla, Carolyn M. Roos, Michael A. Hagler, Bin Zhang, Jordan D. Miller.
Mayo Clinic, Rochester, MN, USA.
Marten AttaAlla, Carolyn M. Roos, Michael A. Hagler, Bin Zhang, Jordan D. Miller.
Mayo Clinic, Rochester, MN, USA.
Single Cell Multi-omics Reveal Novel Cardiac Subpopulation Critical To Valve Morphogenesis
Alexander Merriman1, Mauro Costa1, Peter Kouretas2, Chun Ye2, Deepak Srivastava1.
1Gladstone Institutes, San Francisco, CA, USA, 2University of California, San Francisco, San Francisco, CA, USA.
Alexander Merriman1, Mauro Costa1, Peter Kouretas2, Chun Ye2, Deepak Srivastava1.
1Gladstone Institutes, San Francisco, CA, USA, 2University of California, San Francisco, San Francisco, CA, USA.
Towards A Model Of Subclinical Leaflet Thrombosis With Biochemical And Fluid-structure Interaction
Aaron Barrett1, Jordan A. Brown2, Arash Kheradvar3, Boyce E. Griffith2, Aaron L. Fogelson1.
1University of Utah, Salt Lake City, UT, USA, 2University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 3University of California, Irvine, Irvine, CA, USA.
Aaron Barrett1, Jordan A. Brown2, Arash Kheradvar3, Boyce E. Griffith2, Aaron L. Fogelson1.
1University of Utah, Salt Lake City, UT, USA, 2University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 3University of California, Irvine, Irvine, CA, USA.
Using Artificial Intelligence To Predict The Best Surgical Strategy In Patients With Aortic Valve Regurgitation Or Ascending Aorta Aneurysm. Insights From The Heart Valve Society Aortic Valve Database
Frederiek de Heer1, Bernhard Vennemann2, Laurent de Kerchove3, Emmanuel Lansac4, Monica Contino5, Ismail El-Hamamsy6, Jolanda Kluin1.
1Amsterdam UMC, Amsterdam, Netherlands, 2Institute of Fluid Dynamics, Zurich, Switzerland, 3Cliniques universitaires Saint-Luc, Bruxelles, Belgium, 4La Pitié Hopital Institut de Cardiologie, Paris, France, 5Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco, Milan, Italy, 6The Mount Sinai Hospital, New York, NY, USA.
Frederiek de Heer1, Bernhard Vennemann2, Laurent de Kerchove3, Emmanuel Lansac4, Monica Contino5, Ismail El-Hamamsy6, Jolanda Kluin1.
1Amsterdam UMC, Amsterdam, Netherlands, 2Institute of Fluid Dynamics, Zurich, Switzerland, 3Cliniques universitaires Saint-Luc, Bruxelles, Belgium, 4La Pitié Hopital Institut de Cardiologie, Paris, France, 5Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco, Milan, Italy, 6The Mount Sinai Hospital, New York, NY, USA.
Towards Real-Time Predictive Modeling Of Transcatheter Aortic Valve Replacement Procedures Via Reduced Order Modeling
Imran Shah, Milad Samaee, Alessandro Veneziani, Lakshmi Dasi.
Georgia Institute of Technology, Atlanta, GA, USA.
Imran Shah, Milad Samaee, Alessandro Veneziani, Lakshmi Dasi.
Georgia Institute of Technology, Atlanta, GA, USA.
Multi-omics Integration Reveals Mechanosensitive Pathways That Drive Fibrosis In Mitral Valve Prolapse
Jordan Ellis Morningstar1, Antonia Van Kampen2, Cortney Gensemer1, Taylor Petrucci1, Tyler C. Beck1, Andrew Stoddard1, Robert A. Levine2, Michael A. Borger3, Russell A. Norris1.
1Medical University of South Carolina, Charleston, SC, USA, 2Massachusetts General Hospital, Boston, MA, USA, 3Leipzig Heart Center, Leipzig, Germany.
Jordan Ellis Morningstar1, Antonia Van Kampen2, Cortney Gensemer1, Taylor Petrucci1, Tyler C. Beck1, Andrew Stoddard1, Robert A. Levine2, Michael A. Borger3, Russell A. Norris1.
1Medical University of South Carolina, Charleston, SC, USA, 2Massachusetts General Hospital, Boston, MA, USA, 3Leipzig Heart Center, Leipzig, Germany.
11:00am to 12:30pm
Breakout Session IV: ABSTRACT COMPETITION II
Tissue Engineering & Heart Valve Disease
Moderators: Hanneke Takkenberg, Carlijn Bouten
Tissue Engineering & Heart Valve Disease
Moderators: Hanneke Takkenberg, Carlijn Bouten
Male-female Differences In Homograft Function In Tetralogy Of Fallot
Xu Wang, Carlijn C.E.M van Der Ven, Kevin M. Veen, Johanna J.M Takkenberg, Eleni-Rosalina Andrinopoulou, Pieter C. van de Woestijne, Ad J.J.C Bogers. Erasmus Medical
Center, Rotterdam, Netherlands.
Xu Wang, Carlijn C.E.M van Der Ven, Kevin M. Veen, Johanna J.M Takkenberg, Eleni-Rosalina Andrinopoulou, Pieter C. van de Woestijne, Ad J.J.C Bogers. Erasmus Medical
Center, Rotterdam, Netherlands.
Positive Impact Of Intra Operative Haemostasis Checklist On Post-operative Bleeding And Blood Transfusion Requirements After Heart Valve Surgery
Sobaran Singh Sharma, Yasir Ahmed, Sam Poon, Umair Aslam, Pankaj Kumar.
Morriston Hospital, Swansea, Wales, United Kingdom
Sobaran Singh Sharma, Yasir Ahmed, Sam Poon, Umair Aslam, Pankaj Kumar.
Morriston Hospital, Swansea, Wales, United Kingdom
A Novel Biomimetic Synthetic Expandable Pulmonary Valve In A Chronic Growing Ovine Model
Sophie C Hofferberth1, John P. Carney2, Jill T. Schappa Faustich2, Mossab Saeed1, Richard W. Bianco2, Elazer R. Edelman3, Pedro J. del Nido1.
1Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, 2Experimental Surgical Services, University of Minnesota, Minneapolis, MN, USA, 3Biomedical Engineering Center, Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Sophie C Hofferberth1, John P. Carney2, Jill T. Schappa Faustich2, Mossab Saeed1, Richard W. Bianco2, Elazer R. Edelman3, Pedro J. del Nido1.
1Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, 2Experimental Surgical Services, University of Minnesota, Minneapolis, MN, USA, 3Biomedical Engineering Center, Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Long-term Preclinical Assessment Of Pliable Bioresorbable Synthetic Aortic Heart Valve Prostheses In Sheep
Annemijn Vis1, Bente J. de Kort2, Wojciech Szymczyk2, Jan Willem van Rijswijk2, Sylvia Dekker2, Rob Driessen2, Niels Wijkstra1, Paul F. Gründeman3, Hans W. M. Niessen1, Henk M. Janssen4, Serge H. M. Söntjens4, Patricia Y. W. Dankers2, Anthal I. P. M. Smits2, Carlijn V. C. Bouten2, Jolanda Kluin1.
1Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands, 2Eindhoven University of Technology, Eindhoven, Netherlands, 3University Medical Center Utrecht, Utrecht, Netherlands, 4SyMO-Chem BV, Eindhoven, Netherlands.
Annemijn Vis1, Bente J. de Kort2, Wojciech Szymczyk2, Jan Willem van Rijswijk2, Sylvia Dekker2, Rob Driessen2, Niels Wijkstra1, Paul F. Gründeman3, Hans W. M. Niessen1, Henk M. Janssen4, Serge H. M. Söntjens4, Patricia Y. W. Dankers2, Anthal I. P. M. Smits2, Carlijn V. C. Bouten2, Jolanda Kluin1.
1Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands, 2Eindhoven University of Technology, Eindhoven, Netherlands, 3University Medical Center Utrecht, Utrecht, Netherlands, 4SyMO-Chem BV, Eindhoven, Netherlands.
Spatial And Temporal Pattern Of In Situ Regeneration, Of The Heart Biotech Composit
Magdi Yacoub. Imperial college London, Middlesex, United
Kingdom.e Component Tissue Engineered Valve (HCCV)
Magdi Yacoub. Imperial college London, Middlesex, United
Kingdom.e Component Tissue Engineered Valve (HCCV)
In Vitro Valve-on-chip Platform To Assess Early Calcific Aortic Valve Disease Progression
Ishita Tandon, Christine Shamblin, Alan Woessner, Laís Ferreira, Amanda Walls, Kyle Quinn, Kartik Balachandran.
University of Arkansas, Fayetteville, AR, USA.
Ishita Tandon, Christine Shamblin, Alan Woessner, Laís Ferreira, Amanda Walls, Kyle Quinn, Kartik Balachandran.
University of Arkansas, Fayetteville, AR, USA.
Transapical Ventricular Reshaping Device Eliminates Functional Mitral Regurgitation In Very Enlarged Ventricles In A Swine Model
Chase L. King, Michael Silverman, Keawepono Wang, Stephanie Tom, Yuta Kikuchi, Amanda Maddamma, Daisuke Onohara, Muralidhar Padala.
Emory University, Atlanta, GA, USA.
Chase L. King, Michael Silverman, Keawepono Wang, Stephanie Tom, Yuta Kikuchi, Amanda Maddamma, Daisuke Onohara, Muralidhar Padala.
Emory University, Atlanta, GA, USA.
12:30pm to 1:30pm
LUNCH
12:30pm to 1:30pm
Medtronic Symposia: Breaking News and Techniques in Valve Treatment
12:30-12:35
Welcome and introduction
Chairs: Prof. Klautz, Prof. Meuris
Chairs: Prof. Klautz, Prof. Meuris
12:35-12:47
Aortic valves clinical knowledge acceleration: ACE real-world registry, 500+ patients' results announcement!
Prof. Meuris
Prof. Meuris
12:47-12:59
Live in a box case review: concomitant valves surgery – learn the technique to do both Mitral and Aortic valve replacement at once!
Prof. Verbelen
Prof. Verbelen
12:59-1:11
PPM charts: the feature of the past. Why should you NOT use them in your practice and what to do instead?
Prof. Klautz
Prof. Klautz
1:11-1:23
Live in the box case review: Concomitant AF treatment tips and tricks.
Dr. Bart. Maesen
Dr. Bart. Maesen
1:23-1:30
Final discussion and closure
12:30pm to 1:30pm
TricValve Symposia
12:30-12:40
Tricvalve Case in a Box and Patient Follow Up
Dr. Ángel Sanchez Recalde
Dr. Ángel Sanchez Recalde
12:45- 12:55
Tricvalve, Patient Selection and Clinical Results
Dr. Ángel Sanchez Recalde
Dr. Ángel Sanchez Recalde
12:55- 1:00
Discussion and Questions
1:30pm to 3:00pm
Plenary Session II:
HVD in Women
Moderators: Hanneke Takkenberg, Vinod Thorani, Marta Sitges
HVD in Women
Moderators: Hanneke Takkenberg, Vinod Thorani, Marta Sitges
1:30-1:45
Epidemiology of VHD in Women
Maurice Sarano
Maurice Sarano
1:45-2:00
Pregnancy and VHD
Anna Sannino
Anna Sannino
2:00-2:18
Are Interventions and Outcomes thee Same?
Philippe Pibarot
Philippe Pibarot
2:18-2:30
Any Specific Reasons for Differences?
Elaine Tseng
Elaine Tseng
2:30-3:00
Discussion
3:00pm to 3:30pm
BREAK
3:30pm to 5:30pm
Breakout Session I: Mitral Valve
Mitral Valve Prolapse: From Pathophysiology to Treatment
Moderators: Jose Pomar, Pradeep Yadav, Barbara Vidal
Mitral Valve Prolapse: From Pathophysiology to Treatment
Moderators: Jose Pomar, Pradeep Yadav, Barbara Vidal
3:30-3:50
Keynote: The Problem of Mitral Valve Prolapse
Maurice Sarano
Maurice Sarano
3:50-4:05
New Mechanisms of Development of Mitral Valve Prolapse
Natalia Lopez Andrés
Natalia Lopez Andrés
4:05-4:25
Role Of Genetics in Mitral Valve Prolapse: New Therapeutic Targets?
Ronen Durst
Ronen Durst
4:25-4:45
Mitral Annular Disjunction: How to Diagnose and When and How to Treat
Nina Ajmone Marsan
Nina Ajmone Marsan
4:45-5:00
Robotic, Minimally Invasive or Open Chest Conventional Surgery: Which Technique for Which Patient
Rakesh Suri
Rakesh Suri
5:00-5:15
Transcatheter Mitral Valve Repair Therapies: Limits and Potentials
Michele de Bonis
Michele de Bonis
5:15-5:30
Discussion
3:30pm to 5:30pm
Breakout Session II: Basic Science
Cellular-Extracellular Matrix Cross-Talk in Heart Valve Disease
Moderators: Jordan Miller and Katherine Yutzey
Cellular-Extracellular Matrix Cross-Talk in Heart Valve Disease
Moderators: Jordan Miller and Katherine Yutzey
3:30-3:45
The Pathobiology of Connective Tissue Disorders and Heart Valve Disease
Julie Kessler
Julie Kessler
3:45-3:50
Discussion
3:50-4:05
The ECM in Tissue Engineered Heart Valves: Integrative Physiological Perspectives
Jordan Miller
Jordan Miller
4:05-4:10
Discussion
4:10-4:25
ECM, Cells and Calcification
Carlijn Bouten
Carlijn Bouten
4:25-4:30
Discussion
4:30-4:45
ECM a Its Role in Heart Valve Disease
Jane Grande-Allen
Jane Grande-Allen
4:45-4:50
Discussion
4:50-5:05
The Role of Inflammatory Cell Types and ECM-Related Heart Valve Disease
Katherine Yutzey
Katherine Yutzey
5:05-5:10
Discussion
5:10-5:30
Final Discussion
3:30pm to 5:30pm
Breakout Session III: ABSTRACT COMPETITION III
Aortic Valve & Proximal Aorta
Moderators: Emmanuel Lansac, Juan Umana
Aortic Valve & Proximal Aorta
Moderators: Emmanuel Lansac, Juan Umana
Big Data Allows Improvement In Aortic Valve Repair; Surgical Outcomes For Specific Aortic Valve Cusp Characteristics
Sulayman el Mathari1, Noor Boulidam1, Frederiek de Heer1, Laurent de Kerchove2, Hans-Joachim Schäfers3, Emmanuel Lansac4, Jos W.R. Twisk1, Jolanda Kluin1.
1Amsterdam University Medical Center, Amsterdam, Netherlands, 2Cliniques Universitaires Saint-Luc, Brussels, Belgium, 3Saarland University Medical Center, Homburg, Germany, 4Pitié-Salpêtrière APHP Hospital, Paris, France.
Sulayman el Mathari1, Noor Boulidam1, Frederiek de Heer1, Laurent de Kerchove2, Hans-Joachim Schäfers3, Emmanuel Lansac4, Jos W.R. Twisk1, Jolanda Kluin1.
1Amsterdam University Medical Center, Amsterdam, Netherlands, 2Cliniques Universitaires Saint-Luc, Brussels, Belgium, 3Saarland University Medical Center, Homburg, Germany, 4Pitié-Salpêtrière APHP Hospital, Paris, France.
Gender Bias In Subjective And Objective Assessments Of Frailty And Surgical Risk Among Transcatheter Aortic Valve Patients
Theodora Abah, Aleena Yasin, Theodora Abah, Matthew M. Leipzig, A. Claire, Watkins.
Stanford University, Stanford, CA, USA, Morehouse School of Medicine, Atlanta, GA, USA.
Theodora Abah, Aleena Yasin, Theodora Abah, Matthew M. Leipzig, A. Claire, Watkins.
Stanford University, Stanford, CA, USA, Morehouse School of Medicine, Atlanta, GA, USA.
Non-canonical Telomerase Reverse Transcriptase Controls Osteogenic Differentiation Of Aortic Valve Cells Through Stat5
Cynthia L. St Hilaire.
University of Pittsburgh, PITTSBURGH, PA, USA.
Cynthia L. St Hilaire.
University of Pittsburgh, PITTSBURGH, PA, USA.
Stroke Volume Corroboration For Flow-gradient Patterns Of Severe Aortic Stenosis With Preserved Ejection Fraction
Bart J.J. Velders1, Michiel D. Vriesendorp1, Federico M. Asch2, Michael G. Moront3, Francois Dagenais4, Michael J. Reardon5, Joseph F. Sabik III6, Rolf H.H. Groenwold1, Robert J.M. Klautz1.
1Leiden University Medical Center, Leiden, Netherlands, 2MedStar Health Research Institute, and Georgetown University, Washington DC, DC, USA, 3ProMedica Toledo Hospital, Toledo, OH, USA, 4Quebec Heart and Lung Institute, Quebec, QC, Canada, 5Houston Methodist DeBakey Heart and Vascular Center, Houston, TX, USA, 6University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Bart J.J. Velders1, Michiel D. Vriesendorp1, Federico M. Asch2, Michael G. Moront3, Francois Dagenais4, Michael J. Reardon5, Joseph F. Sabik III6, Rolf H.H. Groenwold1, Robert J.M. Klautz1.
1Leiden University Medical Center, Leiden, Netherlands, 2MedStar Health Research Institute, and Georgetown University, Washington DC, DC, USA, 3ProMedica Toledo Hospital, Toledo, OH, USA, 4Quebec Heart and Lung Institute, Quebec, QC, Canada, 5Houston Methodist DeBakey Heart and Vascular Center, Houston, TX, USA, 6University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Aldehyde Dehyderogenase Is A Novel Actor In The Development Of Aortic Stenosis And Its Product, Retinoic Acid, Inhibits Calcification Processes In Vitro And In Vivo
Mickael Rosa1, Jérome Soquet1, Christina Le Tanno1, Thibault Pamart1, Yoann Sottejeau1, Delphine Corseaux1, Alexandre Ung1, André Vincentelli1, Francis Juthier1, Madjid Tagzirt1, Eloise Borowczac1, Bertrand Vaast1, David Smadja2, Bart Staels1, Eric Van Belle1, Annabelle Dupont1, Sophie Susen1.
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, F-59000 Lille, FRANCE, Lille, France, 2Hematology Department and Biosurgical Research Lab (Carpentier Foundation), European Georges Pompidou Hospital (HEGP; AP-HP.CUP), 75015, Paris, France, Paris, France.
Mickael Rosa1, Jérome Soquet1, Christina Le Tanno1, Thibault Pamart1, Yoann Sottejeau1, Delphine Corseaux1, Alexandre Ung1, André Vincentelli1, Francis Juthier1, Madjid Tagzirt1, Eloise Borowczac1, Bertrand Vaast1, David Smadja2, Bart Staels1, Eric Van Belle1, Annabelle Dupont1, Sophie Susen1.
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, F-59000 Lille, FRANCE, Lille, France, 2Hematology Department and Biosurgical Research Lab (Carpentier Foundation), European Georges Pompidou Hospital (HEGP; AP-HP.CUP), 75015, Paris, France, Paris, France.
In-hospital Outcomes Of Tavr In Patients With Porcelain Aorta
Mohiuddin Cheema, Sarfaraz Memon, Raymond Mckay, Jawad Haider, Robert Hagberg, MD, Sabet Hashim, MD.
Hartford Hospital, Hartford, CT, USA.
Mohiuddin Cheema, Sarfaraz Memon, Raymond Mckay, Jawad Haider, Robert Hagberg, MD, Sabet Hashim, MD.
Hartford Hospital, Hartford, CT, USA.
Sex-specific Temporal Trends In Ascending Aortic Diameters Across 7,171 Images
Siavash Zamirpour, Marko Boskovski, Joseph Leach, Liang Ge, Elaine E. Tseng.
San Francisco VA Health Care System and University of California, San Francisco, CA, USA.
Siavash Zamirpour, Marko Boskovski, Joseph Leach, Liang Ge, Elaine E. Tseng.
San Francisco VA Health Care System and University of California, San Francisco, CA, USA.
First Results Of A Dutch Cohort Of Patients Undergoing Personalized External Aortic Root Support
Athiná M. Kougioumtzoglou1, Dave R. Koolbergen1, Berto J. Bouma1, Robert R. Klautz1, Mark G. Hazekamp2.
1Amsterdam UMC, Amsterdam, Netherlands, 2Leiden UMC, Leiden, Netherlands.
Athiná M. Kougioumtzoglou1, Dave R. Koolbergen1, Berto J. Bouma1, Robert R. Klautz1, Mark G. Hazekamp2.
1Amsterdam UMC, Amsterdam, Netherlands, 2Leiden UMC, Leiden, Netherlands.
Exploring Sex-related Differences In Aortic Regurgitation: Molecular And Clinical Insights
Carolina Tiraplegui Garjón1, Mattie Garaikoetxea Zubillaga2, Alba Sádaba Cipriaín1, Adela Navarro Echeverría1, Ernesto Martín Núñez2, Lara Matilla Cuenca2, Amaya Fernández-Celis2, Alicia Gaínza Calleja1, Virginia Álvarez Asiain1, Rafael Sádaba Sagredo1, Eva Jover García2, Natalia López-Andrés2.
1Hospital Universitario de Navarra, Navarrabiomed, Pamplona, Spain, 2Navarrabiomed, Pamplona, Spain.
Carolina Tiraplegui Garjón1, Mattie Garaikoetxea Zubillaga2, Alba Sádaba Cipriaín1, Adela Navarro Echeverría1, Ernesto Martín Núñez2, Lara Matilla Cuenca2, Amaya Fernández-Celis2, Alicia Gaínza Calleja1, Virginia Álvarez Asiain1, Rafael Sádaba Sagredo1, Eva Jover García2, Natalia López-Andrés2.
1Hospital Universitario de Navarra, Navarrabiomed, Pamplona, Spain, 2Navarrabiomed, Pamplona, Spain.
3:30pm to 5:30pm
Breakout Session IV: ABSTRACT COMPETITION IV
Mitral Valve & Tricuspid Valve
Moderators: Hector Michelena, Vinod Thourani
Mitral Valve & Tricuspid Valve
Moderators: Hector Michelena, Vinod Thourani
Effectiveness And Safety Of Short-term New Oral Anticoagulants(noacs) Versus Warfarin Therapy In Patients Following Mitral Valve Repair
Sam Poon, Yasir Ahmed, Umair Aslam, Sobaran Sharma, Vincenzo
Cianci, Pankaj Kumar. Morriston Hospital, SWANSEA, United Kingdom.
Sam Poon, Yasir Ahmed, Umair Aslam, Sobaran Sharma, Vincenzo
Cianci, Pankaj Kumar. Morriston Hospital, SWANSEA, United Kingdom.
Unravelling Primary Mitral Valve Disease: Differential Histologic And Molecular Patterns Among Aetiologic Subtypes
Amaia Garcia-Peña, Jaime Ibarrola, Adela Navarro, Alba Sadaba, Carolina Tiraplegui, Vanessa Arrieta, Amaya Fernandez-De Celis, Virginia Álvarez, Rafael Sadaba, Natalia Lopez-Andres.
Navarrabiomed, Pamplona, Spain.
Amaia Garcia-Peña, Jaime Ibarrola, Adela Navarro, Alba Sadaba, Carolina Tiraplegui, Vanessa Arrieta, Amaya Fernandez-De Celis, Virginia Álvarez, Rafael Sadaba, Natalia Lopez-Andres.
Navarrabiomed, Pamplona, Spain.
Predictive Patient-specific Modeling Of Transcatheter Edge-to-edge Repair In Humans With Mitral Regurgitation
Natalie Simonian1, Hao Liu1, Sneha Vakamudi2, Mark Pirwitz2, Joseph H. Gorman, III3, Robert C. Gorman3, Michael S. Sacks1.
1University of Texas at Austin, Austin, TX, USA, 2Ascension Texas Cardiovascular, Austin, TX, USA, 3University of Pennsylvania, Philadelphia, PA, USA.
Natalie Simonian1, Hao Liu1, Sneha Vakamudi2, Mark Pirwitz2, Joseph H. Gorman, III3, Robert C. Gorman3, Michael S. Sacks1.
1University of Texas at Austin, Austin, TX, USA, 2Ascension Texas Cardiovascular, Austin, TX, USA, 3University of Pennsylvania, Philadelphia, PA, USA.
Right Ventricular-pulmonary Artery Coupling In Patients Undergoing Transcatheter Mitral Valve Replacement
Thomas Modine1, Sebastan Ludwig2, Walid Ben Ali3, Augustin Coisne4, Jessica Weimann2, Alison Duncan5, Mariama Akodad6, Sabine Bleiziffer7, Georg Nickenig8, Jörg Hausleiter9, Hendrik Ruge10, Matti Adam11, Anna S. Petronio12, Nicolas Dumonteil13, Lars Sondergaard14, Marianna Adamo15, Damiano Regazzoli16, Andrea Garatti17, Tobias Schmidt18, Gry Dahle19, Maurizio Taramasso20, Thomas Walther21, Joerg Kempfert22, Jean-François Obadia23, Simon Redwood24, Gilbert Tang25, Azeem Latib26, Sachin Goel27, Neil Fam28, Martin Andreas29, David Muller30, Paolo Denti31, Fabien Praz32, Ralph Stephan von Bardeleben33, Juan F. Granada34, Lenard Conradi2.
1CHU de Bordeaux, Bordeaux, France, 2University Heart and Vascular Center Hamburg, Hamburg, Germany, 3Montreal Heart Institute, Montreal, QC, Canada, 4CHU de Lille, Lille, France, 5Royal Brompton Hospital, London, United Kingdom, 6St. Paul's Hospital, Vancouver, BC, Canada, 7HDZ NRW, Bad Oeynhausen, Germany, 8Herzzentrum Bonn, Bonn, Germany, 9LMU München, Munich, Germany, 10Deutsches Herzzentrum München, Munich, Germany, 11Herzzentrum Köln, Cologne, Germany, 12University of Pisa, Pisa, Italy, 13Clinique Pasteur, Toulouse, France, 14Rigshospitalet, Copenhagen, Denmark, 15University of Brescia, Brescia, Italy, 16Humanitas Hospital Milan, Milan, Italy, 17San Donato Hospital, Milan, Italy, 18Universitätsklinikum Schleswig-Holstein, Lübeck, Germany, 19Rikshospitalet, Oslo, Norway, 20Klinik Hirslanden, Zürich, Switzerland, 21Universitätsklinikum Frankfurt, Frankfurt, Germany, 22Deutsches Herzzentrum Berlin, Berlin, Germany, 23Louis Pradel Hospital, Lyon, France, 24St. Thomas Hospital, London, United Kingdom, 25Mount Sinai Hospital, New York City, NY, USA, 26Montefiore Medical Center, New York City, NY, USA, 27Houston Methodist Hospital, Houston, TX, USA, 28St. Michael's Hospital, Toronto, ON, Canada, 29Medizinische Universität Wien, Wien, Austria, 30St. Vincent's Hospital, Sydney, Australia, 31San Raffaele Hospital Milan, Milan, Italy, 32Inselspital Bern, Bern, Switzerland, 33Universitätsklinkum Mainuz, Mainz, Germany, 34Cardiovascular Research Foundation, New York City, NY, USA.
Thomas Modine1, Sebastan Ludwig2, Walid Ben Ali3, Augustin Coisne4, Jessica Weimann2, Alison Duncan5, Mariama Akodad6, Sabine Bleiziffer7, Georg Nickenig8, Jörg Hausleiter9, Hendrik Ruge10, Matti Adam11, Anna S. Petronio12, Nicolas Dumonteil13, Lars Sondergaard14, Marianna Adamo15, Damiano Regazzoli16, Andrea Garatti17, Tobias Schmidt18, Gry Dahle19, Maurizio Taramasso20, Thomas Walther21, Joerg Kempfert22, Jean-François Obadia23, Simon Redwood24, Gilbert Tang25, Azeem Latib26, Sachin Goel27, Neil Fam28, Martin Andreas29, David Muller30, Paolo Denti31, Fabien Praz32, Ralph Stephan von Bardeleben33, Juan F. Granada34, Lenard Conradi2.
1CHU de Bordeaux, Bordeaux, France, 2University Heart and Vascular Center Hamburg, Hamburg, Germany, 3Montreal Heart Institute, Montreal, QC, Canada, 4CHU de Lille, Lille, France, 5Royal Brompton Hospital, London, United Kingdom, 6St. Paul's Hospital, Vancouver, BC, Canada, 7HDZ NRW, Bad Oeynhausen, Germany, 8Herzzentrum Bonn, Bonn, Germany, 9LMU München, Munich, Germany, 10Deutsches Herzzentrum München, Munich, Germany, 11Herzzentrum Köln, Cologne, Germany, 12University of Pisa, Pisa, Italy, 13Clinique Pasteur, Toulouse, France, 14Rigshospitalet, Copenhagen, Denmark, 15University of Brescia, Brescia, Italy, 16Humanitas Hospital Milan, Milan, Italy, 17San Donato Hospital, Milan, Italy, 18Universitätsklinikum Schleswig-Holstein, Lübeck, Germany, 19Rikshospitalet, Oslo, Norway, 20Klinik Hirslanden, Zürich, Switzerland, 21Universitätsklinikum Frankfurt, Frankfurt, Germany, 22Deutsches Herzzentrum Berlin, Berlin, Germany, 23Louis Pradel Hospital, Lyon, France, 24St. Thomas Hospital, London, United Kingdom, 25Mount Sinai Hospital, New York City, NY, USA, 26Montefiore Medical Center, New York City, NY, USA, 27Houston Methodist Hospital, Houston, TX, USA, 28St. Michael's Hospital, Toronto, ON, Canada, 29Medizinische Universität Wien, Wien, Austria, 30St. Vincent's Hospital, Sydney, Australia, 31San Raffaele Hospital Milan, Milan, Italy, 32Inselspital Bern, Bern, Switzerland, 33Universitätsklinkum Mainuz, Mainz, Germany, 34Cardiovascular Research Foundation, New York City, NY, USA.
Early And Late Effect Of Annuloplasty Ring Or Band Implantation On Diastolic Mitral Valve Performance: Does It Make A Difference?
Anton Tomsic, MD, PhD1, Elena Sandoval, MD2, Maria C. Meucci, MD1, Takeru Nabeta, MD, PhD1, Manuel Castella, MD2, Anna Muro, MD2, Robert J.M. Klautz, MD, PhD1, Nina Ajmone Marsan, MD, PhD1, Daniel Pereda, MD2, Meindert Palmen, MD, PhD1.
1Leiden University Medical Center, Leiden, Netherlands, 2Hospital Clínic de Barcelona, Barcelona, Spain.
Anton Tomsic, MD, PhD1, Elena Sandoval, MD2, Maria C. Meucci, MD1, Takeru Nabeta, MD, PhD1, Manuel Castella, MD2, Anna Muro, MD2, Robert J.M. Klautz, MD, PhD1, Nina Ajmone Marsan, MD, PhD1, Daniel Pereda, MD2, Meindert Palmen, MD, PhD1.
1Leiden University Medical Center, Leiden, Netherlands, 2Hospital Clínic de Barcelona, Barcelona, Spain.
Biomechanical Comparison Of Transcatheter Edge-to-Edge Repair (TEER) Versus Transcatheter Leaflet Augmenting Repair (TLAR) To Correct Functional Mitral Regurgitation
Gediminas Gaidulis, Qi He, Muralidhar Padala.
Emory University, Atlanta, GA, USA.
Gediminas Gaidulis, Qi He, Muralidhar Padala.
Emory University, Atlanta, GA, USA.
Early And Mid-term Outcomes Of Tricuspid Valve Surgery In Patients With Functional Tricuspid Regurgitation Induced By Atrial Fibrillation
Eun Chae Kim, Jae Woong Choi, Yoon Jin Kang, Ji Seong Kim, Sue Hyun Kim, Yeiwon Lee, Suk Ho Sohn, Ho Young Hwang,
Kyung Hwan Kim. Seoul National University Hospital, Seoul, Korea, Republic of.
Eun Chae Kim, Jae Woong Choi, Yoon Jin Kang, Ji Seong Kim, Sue Hyun Kim, Yeiwon Lee, Suk Ho Sohn, Ho Young Hwang,
Kyung Hwan Kim. Seoul National University Hospital, Seoul, Korea, Republic of.
Concomitant Tricuspid Valve Ring Annuloplasty During Mitral Valve Surgery: A Meta-analysis
Sam Poon, Yasir Ahmed, Jeremy Chan, Umair Aslam, Vincenzo Cianci, Sobaran Sharma, Pankaj Kumar.
Morriston Hospital, SWANSEA, United Kingdom.
Sam Poon, Yasir Ahmed, Jeremy Chan, Umair Aslam, Vincenzo Cianci, Sobaran Sharma, Pankaj Kumar.
Morriston Hospital, SWANSEA, United Kingdom.
Practice Gap In Addressing Tricuspid Valve Regurgitation During Left Sided Valve Surgery For Patients With Rheumatic Heart Disease
Shantanu Pande, Ankush Kotwal, Bipin Chandra, Surendra Kumar
Agarwal. Sanjay Gandhi PGIMS, Lucknow, India.
Shantanu Pande, Ankush Kotwal, Bipin Chandra, Surendra Kumar
Agarwal. Sanjay Gandhi PGIMS, Lucknow, India.
5:30pm to 7:00pm
Poster Competition and Welcome Reception
Friday, 31 March 2023
8:00am to 9:00am
HVS Valve Research Network Information Session – open to all HVS attendees
Panel: Emmanuel Lansac and Aortic and Mitral VRN Core Leaders
Aortic and Mitral Valve Research Networks (VRN)
The Aortic and Mitral VRNs are open Valve Research aiming at gathering international physicians and scientists involved aortic or mitral diseases with the goal to combine forces and share experience in order to advance knowledge. Our Mission is to provide unique databases open to any center taking care for valve repair or valve replacement (surgical or interventional) in order to evaluate the guidelines for surgical indication as well as the place of repair versus replacement with special focus on long term patients outcomes. Junior or senior in the field, you are more than welcome in the Aortic or Mitral VRN!
Panel: Emmanuel Lansac and Aortic and Mitral VRN Core Leaders
Aortic and Mitral Valve Research Networks (VRN)
The Aortic and Mitral VRNs are open Valve Research aiming at gathering international physicians and scientists involved aortic or mitral diseases with the goal to combine forces and share experience in order to advance knowledge. Our Mission is to provide unique databases open to any center taking care for valve repair or valve replacement (surgical or interventional) in order to evaluate the guidelines for surgical indication as well as the place of repair versus replacement with special focus on long term patients outcomes. Junior or senior in the field, you are more than welcome in the Aortic or Mitral VRN!
8:00-8:05
Introduction of VRNs
Emmanuel Lansac
Emmanuel Lansac
8:05-8:20
Aortic VRN Presentation
Kevin Veen
Kevin Veen
8:20-8:35
Mitral VRN Presentation
Evaldas Girdauskas
Evaldas Girdauskas
8:35-8:45
Personalized external aortic root support and valve sparing root replacement in syndromic aortic root aneurysm: a propensity score-matched analysis
Marie Lambrigts
Marie Lambrigts
8:45-8:55
Aortic Valve Sparing Surgery And Myocardial Dysfunction
Charlotte Brega
Charlotte Brega
8:35-9:00
Open Discussion
9:00am to 10:30am
Breakout Session I: Aortic Valve
Deep Dive in the Treatment for Aortic Stenosis
Moderators: Hector Michelena, Kendra Grubb, Sergio Canova
Deep Dive in the Treatment for Aortic Stenosis
Moderators: Hector Michelena, Kendra Grubb, Sergio Canova
9:00-9:15
Will We Ever Reverse Aortic Valve Calcific Degeneration?
Elena Aikawa
Elena Aikawa
9:15-9:25
Leaks after TAVR: Clinical Outcomes and Treatment
Philippe Pibarot
Philippe Pibarot
9:25-9:35
Neuroprotection in TAVR: the role of prosthesis design and complementary devices
Samir Kapadia
Samir Kapadia
9:35-9:45
Durability: Facts and Fiction of TAVR and SAVR
Philippe Pibarot
Philippe Pibarot
9:45-9:55
Targets to Improve Durability of Bioprosthetic Valves
Farshad Amirkhosravi
Farshad Amirkhosravi
9:55-10:05
Advances in Mechanical Aortic Valves: Towards the Holy Grail
Gilles Dreyfus
Gilles Dreyfus
10:05-10:30
Discussion
9:00am to 10:30am
Breakout Session II: Basic Science
The Contribution of the Biomechanical Environment in the Pathobiology Development of Heart Valve Disease
Moderators: Lakshmi Prasad Dasi and Luke Brewster
The Contribution of the Biomechanical Environment in the Pathobiology Development of Heart Valve Disease
Moderators: Lakshmi Prasad Dasi and Luke Brewster
9:00-9:15
The Temporal and Spatial Environment of The Bicuspid Aortic Valve
Hail Kazik
Hail Kazik
9:15-9:20
Discussions
9:20-9:35
Patient-Specific Hemodynamic Alterations in BAV
Lakshmi Prasad Dasi
Lakshmi Prasad Dasi
3:35-9:40
Discussions
9:40-9:55
Molecular Regulators of BAV
Bin Zhou
Bin Zhou
9:55-10:00
Discussion
10:00-10:15
Computational Modeling to Improve Outcomes in Transcatheter Valve Therapies
Taylor Sirset
Taylor Sirset
10:15-10:20
Discussion
10:20-10:30
Final Discussion
9:00am to 10:30am
Breakout Session III: Afib in HVD & Anticoag
Antithrombotic Therapy After Valve Procedure: One Size Fits All?
Moderators: Pradeep Yadav, Miguel Such, and Jorg Kempfert
Antithrombotic Therapy After Valve Procedure: One Size Fits All?
Moderators: Pradeep Yadav, Miguel Such, and Jorg Kempfert
9:00-9:12
Antithrombotic Therapy After Bioprosthetic Surgical Implant - Guidelines and Experiences
Gry Dahle
Gry Dahle
9:12-9:24
Antithrombotic Therapy After TAVR - Guidelines and Experiences
Samir Kapadia
Samir Kapadia
9:24-9:36
Antithrombotic Therapy After TEER - Experiences
Xavier Freixa
Xavier Freixa
9:36-9:48
Antithrombotic Therapy After TMVR - Experiences
Marina Ureña
Marina Ureña
9:48-10:00
Antithrombotic Therapy After TTVR - Experiences
Rodrigo Estevez Loureiro
Rodrigo Estevez Loureiro
10:00-10:30
Discussion
9:00am to 10:30am
Breakout Session IV: Rare HVD/Congenital/Endocarditis
Heart Valve Disease Becomes Global
Moderators: Hanneke Takkenberg, Joseph Bavaria, Marta Sitges
Heart Valve Disease Becomes Global
Moderators: Hanneke Takkenberg, Joseph Bavaria, Marta Sitges
9:00-9:15
Dealing With Rheumatic Heart Disease: Could Be A Homogeneous Program For All The Continents?
Zainab Raissouni
Zainab Raissouni
9:15-9:30
Carcinoid Disease: Rare and Difficult
Daniel Pereda
Daniel Pereda
9:30-9:45
Lead and Other Devices Related Endocarditis: How to Deal
Michael Borger
Michael Borger
9:45-10:00
The Evolving Field on Indications for Intervention in Valve Endocarditis
Eduard Quintana
Eduard Quintana
10:00-10:30
Discussion
10:20am to 11:00am
BREAK
11:00am to 12:30pm
Plenary Session I: Mitral Valve
The Treatment of Mitral Regurgitation: From the Past to the Future
Moderators: Vinod Thourani, Victoria Delgado, Miguel Such
The Treatment of Mitral Regurgitation: From the Past to the Future
Moderators: Vinod Thourani, Victoria Delgado, Miguel Such
11:00-11:12
How To Get A 99% Surgical Repair Rate in a Mitral Valve Program
Jorg Kempfert
Jorg Kempfert
11:12-11:24
FMR: Can We Improve Valve Adaptation to LV Remodelling: Future Perspectives
Jane Grande-Allen
Jane Grande-Allen
11:24-11:36
TEER In FMR: Evidence For Improved Survival but Still Difficult for the Heart Failure Community
Pradeep Yadav
Pradeep Yadav
11:36-11:48
Transcatheter Replacement or TEER For FMR?
Samir Kapadia
Samir Kapadia
11:48-12:00
What is the Role for Surgery in FMR in 2023?
Marc Gillinov
Marc Gillinov
12:00-12:30
Discussion
12:30pm to 1:30pm
Valve Research Network Breakout Meetings
12:30pm to 1:30pm
Edwards lunch symposium
Let's debate on the latest trends of aortic stenosis lifetime management
Chairman: J. Bavaria; Chairwoman: V. Delgado
Aortic stenosis progression: Recent evidence
L. De Kerchove
Management of Aortic Stenosis: where the severity criterion remains critical
X. Freixa
Going beyond the consensus: Management of patients outside the framework
J. Bavaria
Key learnings
V. Delgado and J. Bavaria
Question & Answer
Let's debate on the latest trends of aortic stenosis lifetime management
Chairman: J. Bavaria; Chairwoman: V. Delgado
Aortic stenosis progression: Recent evidence
L. De Kerchove
Management of Aortic Stenosis: where the severity criterion remains critical
X. Freixa
Going beyond the consensus: Management of patients outside the framework
J. Bavaria
Key learnings
V. Delgado and J. Bavaria
Question & Answer
1:30pm to 3:00pm
Plenary Session IV: Aortic
Moderate Aortic Stenosis: From Diagnosis to Therapy
Moderators: Nina Ajmone, Philippe Pibarot, Elaine Tsang
Moderate Aortic Stenosis: From Diagnosis to Therapy
Moderators: Nina Ajmone, Philippe Pibarot, Elaine Tsang
1:45-2:00
The Outcomes and The Challenge of The Diagnosis
Victoria Delgado
Victoria Delgado
1:45-2:00
On Going Trials to Solve the Question to Treat or Not
Philippe Pibarot
Philippe Pibarot
2:00-2:15
How to Treat Moderate AS: TAVR or MICS SAVR?
Kendra Grubb
Kendra Grubb
2:158-2:30
Should We Really Treat Moderate AS or Should We Improve the Diagnosis?
Javier Bermejo
Javier Bermejo
2:30-3:00
Discussion
3:00pm to 3:30pm
BREAK
3:30pm to 5:30pm
Breakout Session I: Mitral Valve
A New Look To Secondary Mitral Regurgitation
Moderators: Vinod Thourani, Maurice Sarano
A New Look To Secondary Mitral Regurgitation
Moderators: Vinod Thourani, Maurice Sarano
3:30-3:50
The clinical and prognostic Impact of Secondary MR in Heart failure
Marta Sitges
Marta Sitges
3:50-4:02
New Insights in the Pathogenesis of Secondary Mitral Regurgitation
Jonathan Beaudoin
Jonathan Beaudoin
4:02-4:24
Understanding Secondary MR from a Left Atrial and Left Ventricular Perspective
Murali Padala
Murali Padala
4:24- 4:36
How To Evaluate Secondary Mitral Regurgitation?
Yong Jin Kim
Yong Jin Kim
4:36-4:48
Current Place For Surgery After COAPT
Vinod Thourani
Vinod Thourani
4:48-5:00
To Clip Or Not To Clip: Real world experience after COAPT and MitraFR
Rutger Van Bommel
Rutger Van Bommel
5:00-5:30
Discussion
3:30pm to 5:30pm
Breakout Session II: Tricuspid Valve
Deep Dive in Secondary Tricuspid Valve Regurgitation
Moderators: Victoria Delgado, Pradeep Yadav
Deep Dive in Secondary Tricuspid Valve Regurgitation
Moderators: Victoria Delgado, Pradeep Yadav
3:30-3:45
Why Secondary MR is Important?
Jerry Braun
Jerry Braun
3:45-4:00
Characterization of Secondary TR – No More Idiopathic TR
Laura Sanchis
Laura Sanchis
4:00-4:15
Indications for Intervention in Secondary TR: Gaps in Evidence
Anna Sannino
Anna Sannino
4:15-4:30
What Are the Ideal Candidates for Surgical Isolated Tricuspid Valve Intervention?
Rakesh Suri
Rakesh Suri
4:30-4:45
Transcatheter Tricuspid Valve Intervention: The Right Technique for the Right Patient
Dabit Arzamendi
Dabit Arzamendi
4:45-5:00
New Randomized Clinical Trials in Secondary TR in the Horizon: What to Expect?
Rodrigo Estevez Loureiro
Rodrigo Estevez Loureiro
5:00-5:30
Discussion
3:30pm to 5:30pm
Breakout Session III: Afib in HVD & Anticoag
A Vicious Circle: Atrial Fibrillation and Atrioventricular Regurgitation
Moderators: Leonardo Rodriguez, Nina Ajmone Marsan, Manuel Castella
A Vicious Circle: Atrial Fibrillation and Atrioventricular Regurgitation
Moderators: Leonardo Rodriguez, Nina Ajmone Marsan, Manuel Castella
3:30-3:44
New understanding of secondary atrioventricular regurgitation
Nina Ajmone Marsan
Nina Ajmone Marsan
3:44-3:58
Outcomes of percutaneous atrial fibrillation endocardial ablation: Update 2022
Ivo Roca-Luque
Ivo Roca-Luque
3:58-4:12
Outcomes of surgical /hybrid atrial fibrillation ablation: Update 2022
Bart Maesen
Bart Maesen
4:12-4:26
The role of atrial fibrillation ablation in treating secondary AV regurgitation
Caroline Van De Heyning
Caroline Van De Heyning
4:26-4:40
When to perform concomitant Afib ablation during valve surgery?
Manuel Castella
Manuel Castella
4:40-5:00
Clinical case debate: MR, TR and Afib - What to do?
Transcatheter valve repair and percutaneous endocardial ablation
Frank van der Kley
Is MICS surgery an option to treat secondary TR, MR and Afib?
Joseph Zacharias
Transcatheter valve repair and percutaneous endocardial ablation
Frank van der Kley
Is MICS surgery an option to treat secondary TR, MR and Afib?
Joseph Zacharias
5:00-5:30
Discussion
3:30pm to 5:30pm
Breakout Session IV: Aorta
The Proximal Aorta: Still Much to Learn
Moderators: Jessica Forcillo, Jolanda Kluin, Eric Roselli
The Proximal Aorta: Still Much to Learn
Moderators: Jessica Forcillo, Jolanda Kluin, Eric Roselli
3:30-3:45
Targets To Prevent Aortic Dilatation in Genetic Disease
Marko Boskovski
Marko Boskovski
3:45-4:00
Phenotyping Proximal Aorta Disease
Hector Michelena
Hector Michelena
4:00-4:15
Predicting Aortic Dilation in Bicuspid Aortic Valve: Role of Imaging
Artur Evangelista
Artur Evangelista
4:15-4:30
Understanding the Mechanism of AR in Ascending Aorta Dilation - Impact On Surgical Therapy
Pastora Gallego
Pastora Gallego
4:30-4:45
How to Achieve Successful Repair in BAV and Proximal Aorta Disease
Hans-Joachim Schäfers
Hans-Joachim Schäfers
4:45-5:00
How to Achieve Successful Repair in TAV and Proximal Aorta Disease
Laurent de Kerchove
Laurent de Kerchove
5:00-5:30
Discussion
5:30pm to 6:30pm
Attendee Reception & Award Announcements
Saturday, 1 April 2023
8:00am to 9:00am
ICHOM Breakfast Session: From Device Outcomes to Lifetime Patient Journeys
Moderators: Emmanuel Lansac and Hanneke Takkenberg
Moderators: Emmanuel Lansac and Hanneke Takkenberg
08:00-08:05
The patient perspective: short videoclip
John Scott, patient representative from Canada
John Scott, patient representative from Canada
08:05-08:20
The ICHOM HVD standard set
Kevin Veen, MD, PhD Erasmus University Medical Centre
Kevin Veen, MD, PhD Erasmus University Medical Centre
08:20-08:25
ISO standards perspective on the ICHOM HVD standard set
Ajit Yoganathan, PhD Associate Chair for Research in The Wallace H. Coulter School of Biomedical Engineering, and the Wallace H. Coulter Distinguished Faculty Chair in Biomedical Engineering, Georgia Institute of Technology & Emory University
Ajit Yoganathan, PhD Associate Chair for Research in The Wallace H. Coulter School of Biomedical Engineering, and the Wallace H. Coulter Distinguished Faculty Chair in Biomedical Engineering, Georgia Institute of Technology & Emory University
08:25-08:30
FDA perspective on the ICHOM HVD standard set
Changfu Wu, PhD Expert Mechanical Engineer, Heart Valve Devices Team (THT2B3), Division of Circulatory Support, Structural and Vascular Devices (DHT2B), Office of Cardiovascular Devices (OHT2), Office of Product Evaluation and Quality (OPEQ), Center for Devices and Radiological Health, U.S. Food and Drug Administration
Changfu Wu, PhD Expert Mechanical Engineer, Heart Valve Devices Team (THT2B3), Division of Circulatory Support, Structural and Vascular Devices (DHT2B), Office of Cardiovascular Devices (OHT2), Office of Product Evaluation and Quality (OPEQ), Center for Devices and Radiological Health, U.S. Food and Drug Administration
08:30-09:00
Panel discussion "Where ISO standards and ARC standard outcomes meet ICHOM HVD standard outcomes"
Session Speakers plus Victoria Delgado, Marta Sitges, Elena Arbelo, and Philippe Pibarot
Session Speakers plus Victoria Delgado, Marta Sitges, Elena Arbelo, and Philippe Pibarot
9:00am to 11:00am
Breakout Session I: Proximal Aorta And Aortic Disease
Moderators: Emmanuel Lansac, Elaine Tseng
Moderators: Emmanuel Lansac, Elaine Tseng
9:00-9:15
When to Intervene the Ascending Aorta in Aortic Stenosis
Jessica Forcillo
Jessica Forcillo
9:15-9:30
Aortic Stenosis and Aortic Root Dilation: Potential Minimal Invasive Solutions
Joseph Zacharias
Joseph Zacharias
9:30-9:45
Root replacement to repair severe AI
Laurent de Kerchove
Laurent de Kerchove
9:45-10:00
David or Yacoub? Same for All?
Maral Ouzounian
Maral Ouzounian
10:00-10:15
Pathophysiological mechanisms of aortic dilation: new therapeutic targets
Elaine Tseng
Elaine Tseng
10:15-10:30
Ascending aorta and arch dilatation: is the future hybrid?
Joseph Bavaria
Joseph Bavaria
10:30-11:00
Discussion
9:00am to 11:00am
Breakout Session II: Tricuspid Valve
Challenging Tricuspid Valve Disease Underrepresented in RCT
Moderators: Gilles Dreyfus, Victoria Delgado, Samir Kapadia
Challenging Tricuspid Valve Disease Underrepresented in RCT
Moderators: Gilles Dreyfus, Victoria Delgado, Samir Kapadia
9:00-9:15
Underrepresented Tricuspid Valve Diseases: We Need More Data. Undertreated?
Cristina Garcia Sebastian
Cristina Garcia Sebastian
9:15-9:30
Imaging Needs To Characterize Degenerative Tricuspid Valve Disease
Laura Sanchis
Laura Sanchis
9:30-9:45
How to Treat Pacemaker Induced-Tricuspid Regurgitation
Nina Ajmone Marsan
Nina Ajmone Marsan
9:45-10:00
Tricuspid Valve Endocarditis: When And How To Intervene?
Carlos Mestres
Carlos Mestres
10:00-10:15
Tricuspid Regurgitation In LVAD Candidates: Is Intervention Needed?
Evgenij Potapov
Evgenij Potapov
10:15-10:30
Long-term Results of Bioprosthesis in the Tricuspid Position
Manuel Castella
Manuel Castella
10:30-11:00
Discussion
9:00am to 11:00am
Breakout Session II: Mitral Valve
Mitral Bioprostheses Degeneration: From Bench to Bedside
Moderators: Jane Grande Allen, Vinod Thourani, James D Thomas
Mitral Bioprostheses Degeneration: From Bench to Bedside
Moderators: Jane Grande Allen, Vinod Thourani, James D Thomas
9:00-9:20
Keynote: Overview of mitral Bioprosthesis: Past, present and future
Sergio Canovas
Sergio Canovas
9:20-9:35
Endothelization of Bioprostheses. Challenges and Potential to Improve
Giuseppina Caligiuri
Giuseppina Caligiuri
9:35-9:55
Next-Generation Tissue Engineered Heart Valves
Rafael Sádaba
Rafael Sádaba
9:55-10:10
Multimodatlity Imaging for the Assessment of Mitral Bioprostheses Caveats and Pirfalls
James D Thomas
James D Thomas
10:10-10:25
The Future Of Surgical Mitral Valve Replacement: Is there any?
Marc Gillinov
Marc Gillinov
10:25-10:40
Percutaneous Treatment of Degenerated Valves: Results and Indications
Marina Ureña
Marina Ureña
10:40-11:00
Discussion
9:00am to 11:00am
Breakout Session II: Aortic Valve
Aortic Insufficiency: New Concepts, New Developments
Moderators: Leonardo Rodriguez, Emmanuel Lansac
Aortic Insufficiency: New Concepts, New Developments
Moderators: Leonardo Rodriguez, Emmanuel Lansac
9:00-9:15
Lifetime Complications of Bicuspud Aortic Valve Condition
Hector Michelena
Hector Michelena
9:15-9:30
Do We Need To Lower The Threshold In Guidelines For AI Intervention?
Laurent de Kerchove
Laurent de Kerchove
9:30-9:45
Repair or Replacement: Never Ending Story
Jolanda Kluin
Jolanda Kluin
9:45-10:00
Homografts: Lost In Translation?
Daniel Pereda
Daniel Pereda
10:00-10:15
Why the Ross Procedure Is Not Expanded Worldwide?
Ismail El-Hamamsy
Ismail El-Hamamsy
10:15-10:30
Native Aortic Endocarditis: Update on Prevention and Treatment
Juan Umana
Juan Umana
10:30-11:00
Discussion
11:00am to 11:30am
BREAK
11:30am to 12:30pm
Plenary Session V: Tricuspid Valve
TR: the rising star - Joint Session with PCR Tricuspid Focus Group
Moderators: Victoria Delgado, Marina Urena, Michele de Bonis
TR: the rising star - Joint Session with PCR Tricuspid Focus Group
Moderators: Victoria Delgado, Marina Urena, Michele de Bonis
11:30-11:32
PCR Tricuspid Focus Group
Victoria Delgado
Victoria Delgado
11:32-11:40
Scope of the Problem
Maurice Sarano
Maurice Sarano
11:40-11:48
Why Surgical Outcomes Have Been Reported Not to Be Good
Gilles Dreyfus
Gilles Dreyfus
11:48-11:56
Real World Experience Outcomes with TEER
Xavier Freixa
Xavier Freixa
11:56-12:04
Will Transcatheter Prosthesis Be the Final Solution?
Rodrigo Estevez Loureiro
Rodrigo Estevez Loureiro
12:04-12:12
Role of Lead Extraction in Treating Lead-Induced TR
Leonardo Rodriguez
Leonardo Rodriguez
12:12-12:30
Discussion